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CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome
Article first published online: 30 JAN 2009
DOI: 10.1038/sj.bjp.0705760
2004 British Pharmacological Society
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How to Cite
Taché, Y., Martinez, V., Wang, L. and Million, M. (2004), CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. British Journal of Pharmacology, 141: 1321–1330. doi: 10.1038/sj.bjp.0705760
Publication History
- Issue published online: 30 JAN 2009
- Article first published online: 30 JAN 2009
- (Received February 11, 2004, Accepted February 25, 2004)
References
- , , & (1999). The role of corticotropin-releasing factor in depression and anxiety disorders. J. Endocrinol., 160, 1–12.
- , , , , , & (1999). Human CRF2α and β splice variants: pharmacological characterization using radioligand binding and a luciferase gene expression assay. Neuropharmacology, 38, 441–448.
- & (2000). Corticotropin-releasing hormone and animal models of anxiety: gene–environment interactions. Biol. Psychiatry, 48, 1175–1198.
- , , , , & (2002). Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. J. Neurosci., 22, 193–199.
- & (2004). CRF and CRF receptors: role in stress responsivity and other behaviors. Annu. Rev. Pharmacol. Toxicol., 44, 525–557.
- , , , & (1998). Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut, 43, 256–261.
- , , , , & (1999). Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J. Comp. Neurol., 415, 285–312.
- , , , , & (2003). Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning. J. Neurosci., 23, 700–707.
- & (1994). Water-avoidance stress-induced c-fos expression in the rat brain and stimulation of fecal output: role of corticotropin-releasing factor. Brain Res., 641, 21–28.
- , , , & (2002). Acute and chronic stress differently affect visceral sensitivity to rectal distension in female rats. Neurogastroenterol. Motil., 14, 75–82.
- , , , & (1992). The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications. Brain Res., 572, 117–125.
- , , , , , , , & (1992). Neurotransmitter-induced hypothalamic-pituitary–adrenal axis responsiveness is defective in inflammatory disease-susceptible Lewis rats: in vivo and in vitro studies suggesting globally defective hypothalamic secretion of corticotropin-releasing hormone. Neuroendocrinology, 55, 600–608.
- (2001). Management of the irritable bowel syndrome. Gastroenterology, 120, 652–668.
- , , , , , , & (1996). Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells. Am. J. Physiol., 271, G884–G892.
- , , , , & (1998). Colonic mucin release in response to immobilization stress is mast cell dependent. Am. J. Physiol, 274, G1094–G1100.
- , , , , , , , & (2004). CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon. J. Neurochem., 88, 1–11.
- , , , , , & (2001). Role of corticotropin-releasing factor-1 (CRF1)-receptor mediated mechanisms in neural pathways modulating colonic hypersensitivity. Gastroenterology, 120 (Suppl 1), A-7.
- , , , , , , & (2002). Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am. J. Physiol. Gastrointest. Liver Physiol., 282, G307–G316.
- , , , & (1995). Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces. Brain Res., 675, 297–302.
- (1999). The relationship between psychosocial parameters and outcome in irritable bowel syndrome. Am. J. Med., 107, 74S–80S.
- & (2002). The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol. Sci., 23, 71–77.
- , , , & (1993). Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression. Am. J. Psychiatry, 150, 656–657.
- , , & (2003). Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology, 125, 1651–1659.
- & (1992). Stress and gastrointestinal motility in animals: a review of the literature. J. Gastrointest. Motil., 1, 83–90.
- , & (1993). Central action of interleukin-1β on intestinal motility in rats: mediation by two mechanisms. Gastroenterology, 104, 377–383.
- , , & (1995). Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. Gastroenterology, 109, 1772–1780.
- , , , & (1999). The role of corticotropin-releasing factor – norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress. Biol. Psychiatry, 46, 1153–1166.
- , & (1998). Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Gut, 42, 845–849.
- , & (2001). Involvement of corticotropin-releasing factor receptor subtype 1 in morphine withdrawal regulation of the brain noradrenergic system. Eur. J. Pharmacol., 430, 277–281.
- , , , , , , , & (2002). Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. Mol. Psychiatry, 7, 474–483 433.
- , & (2000). Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents. J. Med. Chem., 43, 1641–1660.
- & (2002). Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists. Trends Endocrinol. Metab., 13, 436–444.
- , , , , & (1997). Stress-induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells. Neurogastroenterol. Motil., 9, 271–279.
- , & (1991). Conditioned emotional response in rats enhances colonic motility through the central release of corticotropin-releasing factor. Gastroenterology, 100, 964–970.
- , , , , , , , , & (1995). Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc. Natl. Acad. Sci. U.S.A., 92, 10575–10579.
- , , , & (2000). Evidence for visceral hypersensitivity in high-anxiety rats. Physiol. Behav., 69, 379–382.
- , , & (1991). A controlled trial of psychological treatment for the irritable bowel syndrome. Gastroenterology, 100, 450–457.
- & (2003). Persistent central nervous system effects of an adverse early environment: clinical and preclinical studies. Physiol. Behav., 79, 471–478.
- , , , , , , , , , , , , , & (2000). Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc. Natl. Acad. Sci. U.S.A., 97, 6079–6084.
- , , , , & (1999). Urocortin mRNA is expressed in the enteric nervous system of the rat. Neurosci. Lett., 267, 125–128.
- , , , , & (2003). International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. Pharmacol. Rev., 55, 21–26.
- , , , & (2002). Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist. Neuropsychopharmacology, 27, 194–202.
- , , , , , , , & (1993). Synthesis and relative potency of new constrained CRF antagonists. J. Med. Chem., 36, 2860–2867.
- , , , , & (2001). 125I-Antisauvagine-30: a novel and specific high-affinity radioligand for the characterization of corticotropin-releasing factor type 2 receptors. Neuropharmacology, 40, 114–122.
- (1999). The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J. Psychiatr. Res., 33, 181–214.
- , , , , & (2001). Expression of corticotropin-releasing hormone type 1 receptor in paraventricular nucleus after acute stress. Neuroendocrinology, 73, 293–301.
- , , , , , , & (1996). Corticotropin-releasing factor up-regulates its own receptor mRNA in the paraventricular nucleus of the hypothalamus. Brain Res. Mol. Brain Res., 38, 166–170.
- , , , , & (2000). Impaired basal and restraint-induced epinephrine secretion in corticotropin-releasing hormone-deficient mice. Endocrinology, 141, 1142–1150.
- , , , , , , , , , , , & (2000). British society of gastroenterology guidelines for the management of the irritable bowel syndrome. Gut, 47 (Suppl II), ii1–ii19.
- (1998). The role of psychosocial factors in functional gut disease. Eur. J. Surg. Suppl., 583 (Suppl), 37–40.
- & (2001). Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. Peptides, 22, 835–844.
- & (2002). Non-peptidic CRF1 receptor antagonists for the treatment of anxiety, depression and stress disorders. Curr. Drug Target CNS Neurol. Disord., 1, 467–493.
- , , & (2002). Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist. Drug Metab. Dispos., 30, 173–176.
- , , & (1998). Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2ÿ receptor. Mol. Endocrinol., 12, 1077–1085.
- , , & (2001). Colitis induces CRF expression in hypothalamic magnocellular neurons and blunts CRF gene response to stress in rats. Am. J. Physiol., 281, G1203–G1213.
- , , , , , , , & (1996). Effects of the corticotropin-releasing factor (CRF) on rectal afferent nerves in humans. Neurogastroenterol. Motil., 8, 9–18.
- , , & (1988b). Central nervous system effects of corticotropin-releasing factor on gastrointestinal transit in the rat. Gastroenterology, 94, 598–602.
- & (1990). Neurohumoral pathways mediating stress-induced inhibition of gastric acid secretion in rats. Gastroenterology, 98, 1490–1492.
- , , , & (1988a). Stress-induced gastrointestinal secretory and motor responses in rats are mediated by endogenous corticotropin-releasing factor. Gastroenterology, 95, 1510–1517.
- , , , , , , , , , , , , & (2001). Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc. Natl. Acad. Sci. U.S.A., 98, 7570–7575.
- , , & (2002). Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression. J. Neurosci., 22, 991–1001.
- , , & (2000). Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence. Eur. J. Neurosci., 12, 4398–4404.
- & (1999). Experience with anxiety and depression treatment studies: implications for designing irritable bowel syndrome clinical trials. Am. J. Med., 107, 65S–73S.
- & (1998). The arginine vasopressin and corticotrophin-releasing hormone gene transcription responses to varied frequencies of repeated stress in rats. J. Physiol. (Lond.), 510, 605–614.
- , , , & (2000). Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats. Gastroenterology, 119, 1569–1579.
- , , & (2003). Intraperitoneal corticotropin-releasing factor and urocortin induce Fos expression in brain and spinal autonomic nuclei and long lasting stimulation of colonic motility in rats. Brain Res., 974, 70–81.
- , , , & (1998). In vitro excitatory actions of corticotropin-releasing factor on rat colonic motility. J. Auton. Pharmacol., 18, 319–324.
- , , & (1997). Central injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks CRF- and stress-related alterations of gastric and colonic motor function. J. Pharmacol. Exp. Ther., 280, 754–760.
- & (2001). Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats. Brain Res., 893, 29–35.
- , , , & (2004). Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in mice. J. Physiol., [Epub ahead of print] PMID: 14755002 PubMed.
- , , , & (2002). Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2. J. Pharmacol. Exp. Ther., 301, 611–617.
- , , & (2001). V. Stress and irritable bowel syndrome. Am. J. Physiol. Gastrointest.Liver Physiol., 280, G519–G524.
- , & (1999). Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. Curr. Pharm. Des., 5, 289–315.
- , , & (2002). Peripheral CRF activates myenteric neurons in the proximal colon through CRF1 receptor in conscious rats. Am. J. Physiol., 282, G857–G865.
- , , , , , , , , & (2003). A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res., 985, 32–42.
- , , , , & (2002). Human urocortin II, a new CRF-related peptide, displays selective CRF2-mediated action on gastric transit in rats. Am. J. Physiol., 282, G34–G40.
- , , & (2000). Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats. Brain Res., 877, 345–353.
- , , , , , , , & (1997). Constrained corticotropin-releasing factor antagonists with i-(i + 3) Glu–Lys bridges. J. Med. Chem., 40, 3651–3658.
- , & (1998). Involvement of the 5-HT3 receptor in CRH-induce defecation in rats. Am. J. Physiol., 274, G827–G831.
- , & (1992a). CRF in the paraventricular nucleus of the hypothalamus induces dose-related behavioral profile in rats. Brain Res., 574, 70–76.
- , , & (1993b). CRF in the paraventricular nucleus of the hypothalamus stimulates colonic motor activity in fasted rats. Peptides, 14, 743–747.
- , , & (1992b). CRF in the paraventricular nucleus mediates gastric and colonic motor response to restraint stress. Am. J. Physiol., 262, G137–G143.
- , & (1993a). Psychological stress-induced accelerated colonic transit in rats involves hypothalamic corticotropin-releasing factor. Gastroenterology, 104, 716–723.
- , , , & (1994). Microinfusion of corticotropin releasing factor into the locus coeruleus/subcoeruleus stimulates colonic motor function in rats. Brain Res., 644, 101–108.
- , , , & (1999). Differential distribution of urocortin- and corticotropin-releasing factor-like immunoreactivities in the rat brain. Neuroscience, 92, 281–291.
- & (1997). Effects of intermittent tail shock or water avoidance on proximal colonic motor contractility in rats. Physiol. Behav., 62, 233–239.
- , , , , , , , , , , , , , & (2000). Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa. Peptides, 21, 1799–1809.
- , , & (1996). Gastrointestinal symptoms and psychiatric disorders in the general population: findings from NIMH epidemiologic catchement area project. Dig. Dis. Sci., 41, 633–640.
- , , , & (2001). Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo. J. Pharmacol. Exp. Ther., 298, 559–564.
- & (1999). Corticotropin releasing factor receptors and their ligand family. Ann. NY Acad. Sci., 885, 312–328.
- & (2002). Corticotropin releasing factor receptor type 1: molecular cloning and investigation of alternative splicing in the hamster skin. J. Invest. Dermatol., 118, 1065–1072.
- , , & (1998). Psychological and physical stress induce differential effects on human colonic motility. Am. J. Gastroenterol., 93, 985–990. Direct Link:
- , , , , , , , , , & (2001). Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl. Acad. Sci. U.S.A., 98, 2843–2848.
- , & (1995). Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus. J. Neurosci., 15, 2680–2695.
- , , , , , , , , , , , , , & (2002). Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J. Med. Chem., 45, 4737–4747.
- , & (1984). Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat. Science, 224, 889–891.
- , , , , & (1999). Constrained corticotropin releasing factor antagonists (astressin analogues) with long duration of action in the rat. J. Med. Chem., 42, 3175–3182.
- , , , & (1998). Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β-selective antisauvagine-30. Proc. Natl. Acad. Sci. U.S.A., 95, 15264–15269.
- , , , , , , , , & (2004). Effect of a corticotropin-releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome. Gut, in press.
- , , , , , & (1999). Corticotropin-releasing hormone mimics stress-induced rat colonic epithelial pathophysiology in the rat. Am. J. Physiol., 277, G391–G399.
- , , & (2002a). Peripheral corticotropin-releasing factor induces diarrhea in rats: role of CRF1 receptor in fecal watery excretion. Eur. J. Pharmacol., 435, 231–235.
- , , , , & (2002b). Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH. Dig. Dis. Sci., 47, 208–215.
- , , , , , , , , , , , , , & (1996). CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc. Natl. Acad. Sci. U.S.A., 93, 10477–10482.
- , & (2003). Psychological factors in the irritable bowel syndrome. Eur. J. Med. Res., 8, 549–556.
- (2002). The parasympathetic nervous system in the pathophysiology of the gastrointestinal tract. In Handbook of Autonomic Nervous System in Health and Disease, eds. Bolis, C.L., Licinio, J., & Govoni, S. pp. 463–503. New York: Dekker, Inc.
- , , & (2001). Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am. J. Physiol, 280, G173–G177.
- & (2004). Role of peripheral CRF signaling pathways in stress-related alterations of gut motility and mucosal function. Neurogastroenterol. Mot., 16 (Suppl 1), 1–6.
- & (2002). Irritable bowel syndrome: a little understood organic bowel disease Lancet, 360, 555–564.
- & (1999). Regulation of the hypothalamic-pituitary–adrenal axis by cytokines: actions and mechanisms of action. Physiol. Rev., 79, 1–71.
- , , & (1981). Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science, 213, 1394–1397.
- , , , , , , , , , , , & (1995). Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature, 378, 287–292.
- , & (2000). Transneuronal labeling of neurons in the adult rat central nervous system following inoculation of pseudorabies virus into the colon. Cell Tissue Res., 299, 9–26.
- , , , , & (1996). In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology, 137, 5747–5750.
- , , , , , & (1994). Depression and anxiety: role of the locus coeruleus and corticotropin-releasing factor. Brain Res. Bull., 35, 561–572.
- , , , , , , & (1999). Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH. Proc. Natl. Acad. Sci. U.S.A., 96, 8283–8288.
- , , & (1987). Corticotropin-releasing factor directly mediates colonic responses to stress. Am. J. Physiol., 253, G582–G586.
- , , , , , , & (1998). Inhibition of stress-stimulated colonic propulsion by alpha 2-adrenoceptor antagonists in rats. Neurogastroenterol. Motil., 10, 523–532.
- , , , , , & (2000). Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J. Psychiatry Res., 34, 171–181.
- , & (2003). Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends Pharmacol. Sci., 24, 421–427.

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