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  • ADAMS, S., GREEN, P., CLAXTON, R., SIMCOX, S., WILLIAMS, M.V., WALSH, K. & LEEUWENBURGH, C. (2001). Reactive carbonyl formation by oxidative and non-oxidative pathways. Front. Biosci., 6, A1724.
  • AFZAL, M., MATSUGO, S., SASAI, M., XU, B., AOYAMA, K. & TAKEUCHI, T. (2003). Method to overcome photoreaction, a serious drawback to the use of dichlorofluorescin in evaluation of reactive oxygen species. Biochem. Biophys. Res. Commun., 304, 619624.
  • AHMAD, J., COOKE, M.S., HUSSIENI, A., EVANS, M.D., PATEL, K., BURD, R.M., BLEIKER, T.O., HUTCHINSON, P.E. & LUNEC, J. (1999). Urinary thymine dimers and 8-oxo-2′-deoxyguanosine in psoriasis. FEBS Lett., 460, 549553.
  • AKAIKE, T., OKAMOTO, S., SAWA, T., YOSHITAKE, J., TAMURA, F., ICHIMORI, K., MIYAZAKI, K., SASAMOTO, K. & MAEDA, H. (2003). 8-nitroguanosine formation in viral pneumonia and its implication for pathogenesis. Proc. Natl. Acad. Sci. U.S.A., 100, 685690.
  • ALAM, Z.I., JENNER, A., DANIEL, S.E., LEES, A.J., CAIRNS, N., MARSDEN, C.D., JENNER, P. & HALLIWELL, B. (1997). Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J. Neurochem., 69, 11961203.
  • ALDRIDGE, R.E., CHAN, T., VAN DALEN, C.J., SENTHILMOHAN, R., WINN, M., VENGE, P., TOWN, G.I. & KETTLE, A.J. (2002). Eosinophil peroxidase produces hypobromous acid in the airways of stable asthmatics. Free Radic. Biol. Med., 33, 847856.
  • ANDREONI, K.A., KAZUI, M., CAMERON, D.E., NYHAN, D., SEHNERT, S.S., ROHDE, C.A., BULKLEY, G.B. & RISBY, T.H. (1999). Ethane: a marker of lipid peroxidation during cardiopulmonary bypass in humans. Free Radic. Biol. Med., 26, 439445.
  • BANERJEE, D., MADHUSOODANAN, U.K., NAYAK, S. & JACOB, J. (2003). Urinary hydrogen peroxide: a probable marker of oxidative stress in malignancy. Clin. Chim. Acta, 334, 205209.
  • BARTOSZ, G. (2003). Total antioxidant capacity. Adv. Clin. Chem., 37, 219292.
  • BARTSCH, H. & NAIR, J. (2000). New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies. Eur. J. Cancer, 36, 12291234.
  • BASU, S. (2004). Isoprostanes: novel bioactive products of lipid peroxidation – an overview. Free Radic. Res., 38, 105122.
  • BASU, S., WHITEMAN, M., MATTEY, D.L. & HALLIWELL, B. (2001). Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases. Ann. Rheum. Dis., 60, 627631.
  • BECKMAN, J.A., GOLDFINE, A.B., GORDON, M.B. & CREAGER, M.A. (2001). Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation, 103, 16181623.
  • BECKMAN, K.B. & AMES, B.N. (1999). Endogenous oxidative damage of mtDNA. Mutat. Res., 424, 5158.
  • BECKMAN, J.S. & KOPPENOL, W.H. (1996). Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol., 271, C1424C1437.
  • BEGHETTO, C., RENKEN, C., ERIKSSON, O., JORI, G., BERNARDI, P. & RICCHELLI, F. (2000). Implications of the generation of reactive oxygen species by photoactivated calcein for mitochondrial studies. Eur. J. Biochem., 267, 55855592.
  • BENOV, L., SZTEJNBERG, L. & FRIDOVICH, I. (1998). Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic. Biol. Med., 25, 826831.
  • BENZIE, I.F., CHUNG, W. & TOMLINSON, B. (1999). Simultaneous measurement of allantoin and urate in plasma: analytical evaluation and potential clinical application in oxidant:antioxidant balance studies. Clin. Chem., 45, 901904.
  • BENZIE, I.F. & STRAIN, J.J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: the FRAP assay. Anal. Biochem., 239, 7076.
  • BERLINER, L.J., KHRAMTSOV, V., FUJII, H. & CLANTON, T.L. (2001). Unique in vivo applications of spin traps. Free Radic. Biol. Med., 30, 489499.
  • BESSARD, J., CRACOWSKI, J.L., STANKE-LABESQUE, F. & BESSARD, G. (2001). Determination of isoprostaglandin F2alpha type III in human urine by gas chromatography-electronic impact mass spectrometry. Comparison with enzyme immunoassay. J. Chromatogr. B, 754, 333343.
  • BHATTACHARJEE, S., PENNATHUR, S., BYUN, J., CROWLEY, J., MUELLER, D., GISCHLER, J., HOTCHKISS, R.S. & HEINECKE, J.W. (2001). NADPH oxidase of neutrophils elevates o,o′-dityrosine cross-links in proteins and urine during inflammation. Arch. Biochem. Biophys., 395, 6977.
  • BIELSKI, B.H., RICHTER, H.W. & CHAN, P.C. (1975). Some properties of the ascorbate free radical. Ann. NY Acad. Sci., 258, 231237.
  • BILSKI, P., BELANGER, A.G. & CHIGNELL, C.F. (2002). Photosensitized oxidation of 2′,7′-dichlorofluorescin: singlet oxygen does not contribute to the formation of fluorescent oxidation product 2′,7′-dichlorofluorescein. Free Radic. Biol. Med., 33, 938946.
  • BINDOKAS, V.P., KUZNETSOV, A., SREENAN, S., POLONSKY, K.S., ROE, M.W. & PHILIPSON, L.H. (2003). Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J. Biol. Chem., 278, 97969801.
  • BOGDANOV, M.B., BEAL, M.F., MCCABE, D.R., GRIFFIN, R.M. & MATSON, W.R. (1999). A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods. Free Radic. Biol. Med., 27, 647666.
  • BOHNSTEDT, K.C., KARLBERG, B., WAHLUND, L.O., JÖNHAGEN, M.E., BASUN, H. & SCHMIDT, S. (2003). Determination of isoprostanes in urine samples from Alzheimer patients using porous graphitic carbon liquid chromatography-tandem mass spectrometry. J. Chromatogr. B, 796, 1119.
  • BOTTLE, S.E., HANSON, G.R. & MICALLEF, A.S. (2003). Application of the new EPR spin trap 1,1,3-trimethylisoindole N-oxide (TMINO) in trapping HO and related biologically important radicals. Org. Biomol. Chem., 1, 25852589.
  • BROWNLEE, M. (2001). Biochemistry and molecular cell biology of diabetic complications. Nature, 414, 813820.
  • BUETTNER, G.R. (1993). The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch. Biochem. Biophys., 300, 535543.
  • BUETTNER, G.R. & JURKIEWICZ, B.A. (1993). Ascorbate free radical as a marker of oxidative stress: an EPR study. Free Radic. Biol. Med., 14, 4955.
  • BUSS, H., CHAN, T.P., SLUIS, K.B., DOMIGAN, N.M. & WINTERBOURN, C.C. (1997). Protein carbonyl measurement by a sensitive ELISA method. Free Radic. Biol. Med., 23, 361366.
  • BUSS, I.H., SENTHILMOHAN, R., DARLOW, B.A., MOGRIDGE, N., KETTLE, A.J. & WINTERBOURN, C.C. (2003). 3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome. Pediatr. Res., 53, 455462.
  • BUSS, I.H. & WINTERBOURN, C.C. (2002). Protein carbonyl measurement by ELISA. Methods Mol. Biol., 186, 123128.
  • BUTTERFIELD, D.A. (2002). Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic. Res., 36, 13071313.
  • BUTTERFIELD, D.A., BOYD-KIMBALL, D. & CASTEGNA, A. (2003). Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration. J. Neurochem., 86, 13131327.
  • BUXSER, S.E., SAWADA, G. & RAUB, T.J. (1999). Analytical and numerical techniques for evalution of free radical damage in cultured cells using imaging cytometry and fluorescent indicators. Methods Enzymol., 300, 256275.
  • BYUN, J., HENDERSON, J.P., MUELLER, D.M. & HEINECKE, J.W. (1999). 8-Nitro-2′-deoxyguanosine, a specific marker of oxidation by reactive nitrogen species, is generated by the myeloperoxidase-hydrogen peroxide-nitrite system of activated human phagocytes. Biochemistry, 38, 25902600.
  • CALINGASAN, N.Y., UCHIDA, K. & GIBSON, G.E. (1999). Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease. J. Neurochem., 72, 751756.
  • CANDEIAS, L.P., PATEL, K.B., STRATFORD, M.R. & WARDMAN, P. (1993). Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid. FEBS Lett., 333, 151153.
  • CARROLL, M.F. & SCHADE, D.S. (2003). Timing of antioxidant vitamin ingestion alters postprandial proatherogenic serum markers. Circulation, 108, 2431.
  • CASCIOLA-ROSEN, L., WIGLEY, F. & ROSEN, A. (1997). Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. J. Exp. Med., 185, 7179.
  • CHAPMAN, M.L., RUBIN, B.R. & GRACY, R.W. (1989). Increased carbonyl content of proteins in synovial fluid from patients with rheumatoid arthritis. J. Rheumatol., 16, 1518.
  • CHEVION, M., BERENSHTEIN, E. & STADTMAN, E.R. (2000). Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radic. Res., 33 (Suppl), S99S108.
  • CHOI, J., KIM, D.Y., HYUN, J.W., YOON, S.H., CHOI, E.M., HAHM, K.B., RHEE, K.H. & CHUNG, M.H. (2003). Measurement of oxidative damage at individual gene levels by quantitative PCR using 8-hydroxyguanine glycosylase (OGG1). Mutat. Res., 523–524, 225235.
  • CHOUCROUN, P., GILLET, D., DORANGE, G., SAWICKI, B. & DEWITTE, J.D. (2001). Comet assay and early apoptosis. Mutat. Res., 478, 8996.
  • CHOWIENCZYK, P.J., BRETT, S.E., GOPAUL, N.K., MEEKING, D., MARCHETTI, M., RUSSELL-JONES, D.L., ANGGARD, E.E. & RITTER, J.M. (2000). Oral treatment with an antioxidant (raxofelast) reduces oxidative stress and improves endothelial function in men with type II diabetes. Diabetologia, 43, 974977.
  • CLEMENT, M.V., LONG, L.H., RAMALINGAM, J. & HALLIWELL, B. (2002). The cytotoxicity of dopamine may be an artefact of cell culture. J. Neurochem., 81, 414421.
  • CLEMENT, M.V., RAMALINGAM, J., LONG, L.H. & HALLIWELL, B. (2001). The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide. Antioxid. Redox Signal., 3, 157163.
  • CLERMONT, G., VERGELY, C., JAZAYERI, S., LAHET, J.J., GOUDEAU, J.J., LECOUR, S., DAVID, M., ROCHETTE, L. & GIRARD, C. (2002). Systemic free radical activation is a major event involved in myocardial oxidative stress related to cardiopulmonary bypass. Anesthesiology, 96, 8087.
  • COHN, J.S. (2002). Oxidized fat in the diet, postprandial lipaemia and cardiovascular disease. Curr. Opin. Lipidol., 13, 1924.
  • COLLINS, A.R., CADET, J., MOLLER, L., POULSEN, H.E. & VINA, J. (2004). Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells? Arch. Biochem. Biophys., 423, 5765.
  • COLLINS, A.R. & HORVATHOVA, E. (2001). Oxidative DNA damage, antioxidants and DNA repair: applications of the comet assay. Biochem. Soc. Trans., 29, 337341.
  • COOKE, M.S., EVANS, M.D., BURD, R.M., PATEL, K., BARNARD, A., LUNEC, J. & HUTCHINSON, P.E. (2001). Induction and excretion of ultraviolet-induced 8-oxo-2′-deoxyguanosine and thymine dimers in vivo: implications for PUVA. J. Invest. Dermatol., 116, 281285.
  • COOKE, M.S., EVANS, M.D. & LUNEC, J. (2002). DNA repair: insights from urinary lesion analysis. Free Radic. Res., 36, 929932.
  • COUDRAY, C. & FAVIER, A. (2000). Determination of salicylate hydroxylation products as an in vivo oxidative stress marker. Free Radic. Biol. Med., 29, 10641070.
  • DAIBER, A., BACHSCHMID, M., KAVAKLÍ, C., FREIN, D., WENDT, M., ULLRICH, V. & MUNZEL, T. (2003). A new pitfall in detecting biological end products of nitric oxide – nitration, nitros(yl)ation and nitrite/nitrate artefacts during freezing. Nitric Oxide Biol. Chem., 9, 4452.
  • DAIBER, A., OELZE, M., AUGUST, M., WENDT, M., SYDOW, K., WIEBOLDT, H., KLESCHYOV, A.L. & MUNZEL, T. (2004). Detection of superoxide and peroxynitrite in model systems and mitochondria by the luminol analogue L-012. Free Radic. Res., 38, 259269.
  • DALE, O., BERGUM, H., LUND, T., NILSEN, T., AADAHL, P. & STENSETH, R. (2003). A validated method for rapid analysis of ethane in breath and its application in kinetic studies in human volunteers. Free Radic. Res., 37, 815821.
  • DALLE-DONNE, I., GIUSTARINI, D., COLOMBO, R., ROSSI, R. & MILZANI, A. (2003). Protein carbonylation in human diseases. Trends Mol. Med., 9, 169176.
  • DARKO, D., DORNHORST, A., KELLY, F.J., RITTER, J.M. & CHOWIENCZYK, P.J. (2002). Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes. Clin. Sci., 103, 339344.
  • DARLEY-USMAR, V. & HALLIWELL, B. (1996). Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm. Res., 13, 649662.
  • DARLEY-USMAR, V., WISEMAN, H. & HALLIWELL, B. (1995). Nitric oxide and oxygen radicals: a question of balance. FEBS Lett., 369, 131135.
  • DAVIES, M.J., FU, S., WANG, H. & DEAN, R.T. (1999). Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radic. Biol. Med., 27, 11511163.
  • DENTON, M.J., SPENCER, N. & ARNSTEIN, H.R. (1975). Biochemical and enzymic changes during erythrocyte differentiation. The significance of the final cell division. Biochem. J., 146, 205211.
  • DIZDAROGLU, M. (1992). Oxidative damage to DNA in mammalian chromatin. Mutat. Res., 275, 331342.
  • DIZDAROGLU, M., JARUGA, P., BIRINCIOGLU, M. & RODRIGUEZ, H. (2002). Free radical-induced damage to DNA: mechanisms and measurement. Free Radic. Biol. Med., 32, 11021115.
  • DOEHNER, W., SCHOENE, N., RAUCHHAUS, M., LEYVA-LEON, F., PAVITT, D.V., REAVELEY, D.A., SCHULER, G., COATS, A.J., ANKER, S.D. & HAMBRECHT, R. (2002). Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies. Circulation, 105, 26192624.
  • DOUKI, T., COURT, M., SAUVAIGO, S., ODIN, F. & CADET, J. (2000). Formation of the main UV-induced thymine dimeric lesions within isolated and cellular DNA as measured by high performance liquid chromatography–tandem mass spectrometry. J. Biol. Chem., 275, 1167811685.
  • DOULIAS, P.T., CHRISTOFORIDIS, S., BRUNK, U.T. & GALARIS, D. (2003). Endosomal and lysosomal effects of desferrioxamine: protection of HeLa cells from hydrogen peroxide-induced DNA damage and induction of cell-cycle arrest. Free Radic. Biol. Med., 35, 719728.
  • DRAGSTED, L.O. (2003). Antioxidant actions of polyphenols in humans. Int. J. Vitam. Nutr. Res., 73, 112119.
  • DRAPER, H.H., CSALLANY, A.S. & HADLEY, M. (2000). Urinary aldehydes as indicators of lipid peroxidation in vivo. Free Radic. Biol. Med., 29, 10711077.
  • DRUMMEN, G.P., OP DEN KAMP, J.A. & POST, J.A. (1999). Validation of the peroxidative indicators, cis-parinaric acid and parinaroyl-phospholipids, in a model system and cultured cardiac myocytes. Biochim. Biophys. Acta, 1436, 370382.
  • DRUMMEN, G.P., VAN LIEBERGEN, L.C., OP DEN KAMP, J.A. & POST, J.A. (2002). C11-BODIPY(581/591), an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology. Free Radic. Biol. Med., 33, 473490.
  • DUFFY, S.J., GOKCE, N., HOLBROOK, M., HUANG, A., FREI, B., KEANEY JR, J.F. & VITA, J.A. (1999). Treatment of hypertension with ascorbic acid. Lancet, 354, 20482049.
  • DUFFY, S.J., KEANEY JR, J.F., HOLBROOK, M., GOKCE, N., SWERDLOFF, P.L., FREI, B. & VITA, J.A. (2001). Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation, 104, 151156.
  • DUNCAN, M.W. (2003). A review of approaches to the analysis of 3-nitrotyrosine. Amino Acids, 25, 351361.
  • DUPONT, I., BERTHOU, F., BODENEZ, P., BARDOU, L., GUIRRIEC, C., STEPHAN, N., DREANO, Y. & LUCAS, D. (1999). Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. Drug Metab. Dispos., 27, 322326.
  • D'USCIO, L.V., MILSTIEN, S., RICHARDSON, D., SMITH, L. & KATUSIC, Z.S. (2003). Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ. Res., 92, 8895.
  • DUTHIE, S.J., MA, A., ROSS, M.A. & COLLINS, A.R. (1996). Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res., 56, 12911295.
  • ENGLAND, T., BEATTY, E., REHMAN, A., NOUROOZ-ZADEH, J., PEREIRA, P., O'REILLY, J., WISEMAN, H., GEISSLER, C. & HALLIWELL, B. (2000). The steady-state levels of oxidative DNA damage and of lipid peroxidation (F2-isoprostanes) are not correlated in healthy human subjects. Free Radic. Res., 32, 355362.
  • EVANS, M.D., DIZDAROGLU, M. & COOKE, M.S. (2003). Oxidative DNA damage and disease: induction, repair and significance. Mutat. Res., 7780, 162.
  • FAM, S.S. & MORROW, J.D. (2003). The isoprostanes: unique products of arachidonic acid oxidation – a review. Curr. Med. Chem., 10, 17231740.
  • FAULKNER, K. & FRIDOVICH, I. (1993). Luminol and lucigenin as detectors for O2. Free Radic. Biol. Med., 15, 447451.
  • FECHNER, A., BOHME, C., GROMER, S., FUNK, M., SCHIRMER, R. & BECKER, K. (2001). Antioxidant status and nitric oxide in the malnutrition syndrome kwashiorkor. Pediatr. Res., 49, 237243.
  • FERDINANDY, P. & SCHULZ, R. (2003). Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia–reperfusion injury and preconditioning. Br. J. Pharmacol., 138, 532543.
  • FERGER, B., THEMANN, C., ROSE, S., HALLIWELL, B. & JENNER, P. (2001). 6-hydroxydopamine increases the hydroxylation and nitration of phenylalanine in vivo: implication of peroxynitrite formation. J. Neurochem., 78, 509514.
  • FESSEL, J.P., PORTER, N.A., MOORE, K.P., SHELLER, J.R. & ROBERTS II, L.J. (2002). Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc. Natl. Acad. Sci. U.S.A., 99, 1671316718.
  • FLOYD, R.A., HENSLEY, K., JAFFERY, F., MAIDT, L., ROBINSON, K., PYE, Q. & STEWART, C. (1999). Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps. Life Sci., 65, 18931899.
  • FRANK, J., POMPELLA, A. & BIESALSKI, H.K. (2000). Histochemical visualization of oxidant stress. Free Radic. Biol. Med., 29, 10961105.
  • FRISCHER, T., PULLWITT, A., KUHR, J., MEINERT, R., HASCHKE, N., STUDNICKA, M. & LUBEC, G. (1997). Aromatic hydroxylation in nasal lavage fluid following ambient ozone exposure. Free Radic. Biol. Med., 22, 201207.
  • FROST, M.T., HALLIWELL, B. & MOORE, K.P. (2000). Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts. Biochem. J., 345, 453458.
  • FU, S., DAVIES, M.J., STOCKER, R. & DEAN, R.T. (1998). Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque. Biochem. J., 333, 519525.
  • GACKOWSKI, D., ROZALSKI, R., ROSZKOWSKI, K., JAWIEN, A., FOKSINSKI, M. & OLINSKI, R. (2001). 8-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine levels in human urine do not depend on diet. Free Radic. Res., 35, 825832.
  • GALLI, R.L., SHUKITT-HALE, B., YOUDIM, K.A. & JOSEPH, J.A. (2002). Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits. Ann. NY Acad. Sci., 959, 128132.
  • GAUT, J.P., BYUN, J., TRAN, H.D. & HEINECKE, J.W. (2002a). Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography–electrospray ionization tandem mass spectrometry. Anal. Biochem., 300, 252259.
  • GAUT, J.P., BYUN, J., TRAN, H.D., LAUBER, W.M., CARROLL, J.A., HOTCHKISS, R.S., BELAAOUAJ, A. & HEINECKE, J.W. (2002b). Myeloperoxidase produces nitrating oxidants in vivo. J. Clin. Invest., 109, 13111319.
  • GEISZT, M., WITTA, J., BAFFI, J., LEKSTROM, K. & LETO, T.L. (2003). Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J., 17, 15021504.
  • GHISELLI, A., LAURENTI, O., DE MATTIA, G., MAIANI, G. & FERRO-LUZZI, A. (1992). Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients. Free Radic. Biol. Med., 13, 621626.
  • GIULIVI, C. & DAVIES, K.J. (2001). Mechanism of the formation and proteolytic release of H2O2-induced dityrosine and tyrosine oxidation products in hemoglobin and red blood cells. J. Biol. Chem., 276, 2412924136.
  • GOKCE, N., KEANEY JR, J.F., FREI, B., HOLBROOK, M., OLESIAK, M., ZACHARIAH, B.J., LEEUWENBURGH, C., HEINECKE, J.W. & VITA, J.A. (1999). Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation, 99, 32343240.
  • GOLDEN, M.H. & RAMDATH, D. (1987). Free radicals in the pathogenesis of kwashiorkor. Proc. Nutr. Soc., 46, 5368.
  • GOPAUL, N.K., HALLIWELL, B. & ANGGARD, E.E. (2000). Measurement of plasma F2-isoprostanes as an index of lipid peroxidation does not appear to be confounded by diet. Free Radic. Res., 33, 115127.
  • GOPAUL, N.K., MANRAJ, M.D., HEBE, A., LEE KWAI YAN, S., JOHNSTON, A., CARRIER, M.J. & ANGGARD, E.E. (2001). Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism. Diabetologia, 44, 706712.
  • GREENACRE, S.A. & ISCHIROPOULOS, H. (2001). Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction. Free Radic. Res., 34, 541581.
  • GROOTVELD, M. & HALLIWELL, B. (1986). Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids. Biochem. J., 237, 499504.
  • GROOTVELD, M. & HALLIWELL, B. (1987). Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo? Biochem. J., 243, 803808.
  • GRZELAK, A., RYCHLIK, B. & BARTOSZ, G. (2000). Reactive oxygen species are formed in cell culture media. Acta Biochim. Pol., 47, 11971198.
  • GUAN, W., OSANAI, T., KAMADA, T., HANADA, H., ISHIZAKA, H., ONODERA, H., IWASA, A., FUJITA, N., KUDO, S., OHKUBO, T. & OKUMURA, K. (2003). Effect of allopurinol pretreatment on free radical generation after primary coronary angioplasty for acute myocardial infarction. J. Cardiovasc. Pharmacol., 41, 699705.
  • GUAN, W., OSANAI, T., KAMADA, T., ISHIZAKA, H., HANADA, H. & OKUMURA, K. (1999). Time course of free radical production after primary coronary angioplasty for acute myocardial infarction and the effect of vitamin C. Jpn. Circ. J., 63, 924928.
  • HAGEN, T.M., HUANG, S., CURNUTTE, J., FOWLER, P., MARTINEZ, V., WEHR, C.M., AMES, B.N. & CHISARI, F.V. (1994). Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc. Natl. Acad. Sci. U.S.A., 91, 1280812812.
  • HALLIWELL, B. (1978). Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: the key role of superoxide dismutase. Cell Biol. Int. Rep., 2, 113128.
  • HALLIWELL, B. (1989). Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action? Free Radic. Biol. Med., 7, 645651.
  • HALLIWELL, B. (1991). Drug antioxidant effects. A basis for drug selection? Drugs, 42, 569605.
  • HALLIWELL, B. (1995). Antioxidant characterization. Methodology and mechanism. Biochem. Pharmacol., 49, 13411348.
  • HALLIWELL, B. (1999a). Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept. Nutr. Rev., 57, 104113.
  • HALLIWELL, B. (1999b). Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition. Mutat. Res., 443, 3752.
  • HALLIWELL, B. (1999c). Vitamin C: poison, prophylactic or panacea? Trends Biochem. Sci., 24, 255259.
  • HALLIWELL, B. (2000a). Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? Cardiovasc. Res., 47, 410418.
  • HALLIWELL, B. (2000b). The antioxidant paradox. Lancet, 355, 11791180.
  • HALLIWELL, B. (2000c). Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come? Am. J. Clin. Nutr., 72, 10821087.
  • HALLIWELL, B. (2001). Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging, 18, 685716.
  • HALLIWELL, B. (2002a). Vitamin E and the treatment and prevention of diabetes: a case for a controlled clinical trial. Singapore Med. J., 43, 479484.
  • HALLIWELL, B. (2002b). Effect of diet on cancer development: is oxidative DNA damage a biomarker? Free Radic. Biol. Med., 32, 968974.
  • HALLIWELL, B. (2003a). Oxidative stress in cell culture: an under-appreciated problem? FEBS Lett., 540, 36.
  • HALLIWELL, B. (2003b). Health benefits of eating chocolate. Nature, 426, 787.
  • HALLIWELL, B., CLEMENT, M.V. & LONG, L.H. (2000). Hydrogen peroxide in the human body. FEBS Lett., 486, 1013.
  • HALLIWELL, B. & GUTTERIDGE, J.M. (1999). Free Radicals in Biology and Medicine. Oxford, U.K.: Oxford University Press.
  • HALLIWELL, B. & KAUR, H. (1997). Hydroxylation of salicylate and phenylalanine as assays for hydroxyl radicals: a cautionary note visited for the third time. Free Radic. Res., 27, 239244.
  • HALLIWELL, B., LONG, L.H., YEE, T.P., LIM, S. & KELLY, R. (2004a). Establishing biomarkers of oxidative stress. The measurement of hydrogen peroxide in human urine. Curr. Med. Chem., (in press).
  • HALLIWELL, B., RAFTER, J. & JENNER, A. (2004b). Health promotion by flavonoids, tocopherols, tocotrienols and other phenols. Direct or indirect effects? Antioxidant or not? Am. J. Clin. Nutr., (in press).
  • HALLIWELL, B., ZHAO, K. & WHITEMAN, M. (1999). Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies. Free Radic. Res., 31, 651669.
  • HAN, J.Y., TAKESHITA, K. & UTSUMI, H. (2001). Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles. Free Radic. Biol. Med., 30, 516525.
  • HANAOKA, T., NAIR, J., TAKAHASHI, Y., SASAKI, S., BARTSCH, H. & TSUGANE, S. (2002). Urinary level of 1,N(6)-ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and omega 6-polyunsaturated fatty acid intake in postmenopausal Japanese women. Int. J. Cancer, 100, 7175.
  • HARRISON, D.G., CAI, H., LANDMESSER, U. & GRIENDLING, K.K. (2003). Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. J. Renin Angiotensin Aldosterone Syst., 4, 5161.
  • HARTH, R., GERLACH, M., RIEDERER, P. & GOTZ, M.E. (2001). A highly sensitive method for the determination of protein bound 3,4-dihydroxyphenylalanine as a marker for post-translational protein hydroxylation in human tissues ex vivo. Free Radic. Res., 35, 167174.
  • HAYWOOD, R.M., WARDMAN, P., GAULT, D.T. & LINGE, C. (1999). Ruby laser irradiation (694 nm) of human skin biopsies: assessment by electron spin resonance spectroscopy of free radical production and oxidative stress during laser depilation. Photochem. Photobiol., 70, 348352.
  • HAZEN, S.L. & HEINECKE, J.W. (1997). 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J. Clin. Invest., 99, 20752081.
  • HAZEN, S.L., HSU, F.F., DUFFIN, K. & HEINECKE, J.W. (1996). Molecular chlorine generated by the myeloperoxidase–hydrogen peroxide–chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols. J. Biol. Chem., 271, 2308023088.
  • HEADLAM, H.A. & DAVIES, M.J. (2003). Cell-mediated reduction of protein and peptide hydroperoxides to reactive free radicals. Free Radic. Biol. Med., 34, 4455.
  • HEISS, C., DEJAM, A., KLEINBONGARD, P., SCHEWE, T., SIES, H. & KELM, M. (2003). Vascular effects of cocoa rich in flavan-3-ols. JAMA, 290, 10301031.
  • HELLSTEN, Y., SVENSSON, M., SJODIN, B., SMITH, S., CHRISTENSEN, A., RICHTER, E.A. & BANGSBO, J. (2001). Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise. Free Radic. Biol. Med., 31, 13131322.
  • HELMERSSON, J. & BASU, S. (2001). F2-isoprostane and prostaglandin F2 metabolite excretion rate and day to day variation in healthy humans. Prostaglandin Leukot. Essent. Fatty Acid, 65, 99102.
  • HEMPEL, S.L., BUETTNER, G.R., O'MALLEY, Y.Q., WESSELS, D.A. & FLAHERTY, D.M. (1999). Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic. Biol. Med., 27, 146159.
  • HENDERSON, J.P., BYUN, J., TAKESHITA, J. & HEINECKE, J.W. (2003). Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue. J. Biol. Chem., 278, 2352223528.
  • HENZLER, T. & STEUDLE, E. (2000). Transport and metabolic degradation of hydrogen peroxide in Chara corallina: model calculations and measurements with the pressure probe suggest transport of H(2)O(2) across water channels. J. Exp. Bot., 51, 20532066.
  • HIMMELFARB, J., MCMENAMIN, M.E., LOSETO, G. & HEINECKE, J.W. (2001). Myeloperoxidase-catalyzed 3-chlorotyrosine formation in dialysis patients. Free Radic. Biol. Med., 31, 11631169.
  • HIRAMOTO, K., KIDA, T. & KIKUGAWA, K. (2002). Increased urinary hydrogen peroxide levels caused by coffee drinking. Biol. Pharm. Bull., 25, 14671471.
  • HIRAMOTO, K., LI, X., MAKIMOTO, M., KATO, T. & KIKUGAWA, K. (1998). Identification of hydroxy-hydroquinone in coffee as a generator of reactive oxygen species that break DNA single strands. Mutat. Res., 419, 4351.
  • HSIEH, Y.S., CHEN, B.C., SHIOW, S.J., WANG, H.C., HSU, J.D. & WANG, C.J. (2002). Formation of 8-nitroguanine in tobacco cigarette smokers and in tobacco smoke-exposed Wistar rats. Chem. Biol. Interact, 140, 6780.
  • HUANG, A., VITA, J.A., VENEMA, R.C. & KEANEY JR, J.F. (2000). Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J. Biol. Chem., 275, 1739917406.
  • HUANG, H.Y., APPEL, L.J., CROFT, K.D., MILLER III, E.R., MORI, T.A. & PUDDEY, I.B. (2002). Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial. Am. J. Clin. Nutr., 76, 549555.
  • ICHIMORI, K., FUKUYAMA, N., NAKAZAWA, H., ARATANI, Y., KOYAMA, H., TAKIZAWA, S., KAMEOKA, Y., ISHIDA-OKAWARA, A., KOHI, F. & SUZUKI, K. (2003). Myeloperoxidase has directly-opposed effects on nitration reaction – study on myeloperoxidase-deficient patient and myeloperoxidase-knockout mice. Free Radic. Res., 37, 481489.
  • INDART, A., VIANA, M., GROOTVELD, M.C., SILWOOD, C.J., SANCHEZ-VERA, I. & BONET, B. (2002). Teratogenic actions of thermally-stressed culinary oils in rats. Free Radic. Res., 36, 10511058.
  • INGELMAN-SUNDBERG, M., KAUR, H., TERELIUS, Y., PERSSON, J.O. & HALLIWELL, B. (1991). Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted. Biochem. J., 276, 753757.
  • ISCHIROPOULOS, H., GOW, A., THOM, S.R., KOOY, N.W., ROYALL, J.A. & CROW, J.P. (1999). Detection of reactive nitrogen species using 2,7-dichlorodihydrofluorescein and dihydrorhodamine 123. Methods Enzymol., 301, 367373.
  • IULIANO, L., PRATICO, D., GRECO, C., MANGIERI, E., SCIBILIA, G., FITZGERALD, G.A. & VIOLI, F. (2001). Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA. J. Am. Coll. Cardiol., 37, 7680.
  • JIALAL, I., DEVARAJ, S. & VENUGOPAL, S.K. (2002). Oxidative stress, inflammation, and diabetic vasculopathies: the role of alpha tocopherol therapy. Free Radic. Res., 36, 13311336.
  • JOBSIS, R.Q., SCHELLEKENS, S.L., FAKKEL-KROESBERGEN, A., RAATGEEP, R.H. & DE JONGSTE, J.C. (2001). Hydrogen peroxide in breath condensate during a common cold. Mediators Inflamm., 10, 351354.
  • JURKIEWICZ, B.A. & BUETTNER, G.R. (1996). EPR detection of free radicals in UV-irradiated skin: mouse versus human. Photochem. Photobiol., 64, 918922.
  • KANABROCKI, E.L., MURRAY, D., HERMIDA, R.C., SCOTT, G.S., BREMNER, W.F., RYAN, M.D., AYALA, D.E., THIRD, J.L., SHIRAZI, P., NEMCHAUSKY, B.A. & HOOPER, D.C. (2002). Circadian variation in oxidative stress markers in healthy and type II diabetic men. Chronobiol. Int., 19, 423439.
  • KANSKI, J., ALTERMAN, M.A. & SCHONEICH, C. (2003). Proteomic identification of age-dependent protein nitration in rat skeletal muscle. Free Radic. Biol. Med., 35, 12291239.
  • KAROUI, H., CLÉMENT, J.L., ROCKENBAUER, A., SIRI, D. & TORDO, P. (2004). Synthesis and structure of 5,5-diethoxycarbonyl-1-pyrroline N-oxide (DECPO). Application to superoxide radical trapping. Tetrah. Lett., 45, 149152.
  • KASAI, H. (2002). Chemistry-based studies on oxidative DNA damage: formation, repair, and mutagenesis. Free Radic. Biol. Med., 33, 450456.
  • KATO, Y., MARUYAMA, W., NAOI, M., HASHIZUME, Y. & OSAWA, T. (1998). Immunohistochemical detection of dityrosine in lipofuscin pigments in the aged human brain. FEBS Lett., 439, 231234.
  • KAUR, H., EDMONDS, S.E., BLAKE, D.R. & HALLIWELL, B. (1996). Hydroxyl radical generation by rheumatoid blood and knee joint synovial fluid. Ann. Rheum. Dis., 55, 915920.
  • KAUR, H. & HALLIWELL, B. (1990). Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products. Chem. Biol. Interact., 73, 235247.
  • KAUR, H. & HALLIWELL, B. (1994). Detection of hydroxyl radicals by aromatic hydroxylation. Methods Enzymol., 233, 6782.
  • KAUR, H., LYRAS, L., JENNER, P. & HALLIWELL, B. (1998). Artefacts in HPLC detection of 3-nitrotyrosine in human brain tissue. J. Neurochem., 70, 22202223.
  • KAUR, H., WHITEMAN, M. & HALLIWELL, B. (1997). Peroxynitrite-dependent aromatic hydroxylation and nitration of salicylate and phenylalanine. Is hydroxyl radical involved? Free Radic. Res., 26, 7182.
  • KAWAKAMI, N., HAYAKAWA, T., SHIMOHAMA, S. & FUJIMOTO, S. (1999). The hydroxyl radical formation system in polymorphonuclear leukocytes. Biol. Pharm. Bull., 22, 10341037.
  • KEANEY JR, J.F., LARSON, M.G., VASAN, R.S., WILSON, P.W., LIPINSKA, I., COREY, D., MASSARO, J.M., SUTHERLAND, P., VITA, J.A. & BENJAMIN, E.J. (2003). Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler. Thromb. Vasc. Biol., 23, 434439.
  • KELM, M., PREIK-STEINHOFF, H., PREIK, M. & STRAUER, B.E. (1999). Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine–NO pathway. Cardiovasc. Res., 41, 765772.
  • KESTON, A.S. & BRANDT, R. (1965). The fluorometric analysis of ultramicro quantities of hydrogen peroxide. Anal. Biochem., 11, 15.
  • KETTLE, A.J. & WINTERBOURN, C.C. (1994). Superoxide-dependent hydroxylation by myeloperoxidase. J. Biol. Chem., 269, 1714617151.
  • KHAN, N., WILMOT, C.M., ROSEN, G.M., DEMIDENKO, E., SUN, J., JOSEPH, J., O'HARA, J., KALYANARAMAN, B. & SWARTZ, H.M. (2003). Spin traps: in vitro toxicity and stability of radical adducts. Free Radic. Biol. Med., 34, 14731481.
  • KIRSCHBAUM, B. (2002). Correlative studies of urine fluorescence and free radical indicators. Clin. Nephrol., 58, 344349.
  • KOBAYASHI, K., HARADA, Y. & HAYASHI, K. (1991). Kinetic behavior of the monodehydroascorbate radical studied by pulse radiolysis. Biochemistry, 30, 83108315.
  • KOJDA, G. & HARRISON, D. (1999). Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res., 43, 562571.
  • KOOY, N.W., LEWIS, S.J., ROYALL, J.A., YE, Y.Z., KELLY, D.R. & BECKMAN, J.S. (1997). Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite. Crit. Care Med., 25, 812819.
  • KOTAKE, Y. (1999). Pharmacologic properties of phenyl N-tert-butylnitrone. Antioxid. Redox Signal., 1, 481499.
  • KUGE, N., KOHZUKI, M. & SATO, T. (1999). Relation between natriuresis and urinary excretion of hydrogen peroxide. Free Radic. Res., 30, 119123.
  • LABORIE, S., LAVOIE, J.C. & CHESSEX, P. (2000). Increased urinary peroxides in newborn infants receiving parenteral nutrition exposed to light. J. Pediatr., 136, 628632.
  • LAMB, N.J., GUTTERIDGE, J.M., BAKER, C., EVANS, T.W. & QUINLAN, G.J. (1999). Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination. Crit. Care Med., 27, 17381744.
  • LAPCHAK, P.A. & ARAUJO, D.M. (2003). Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke. CNS Drug Rev., 9, 253262.
  • LASSEGUE, B. & CLEMPUS, R.E. (2003). Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am. J. Physiol. Regul. Integr. Comp. Physiol., 285, R277297.
  • LAWRENCE, A., JONES, C.M., WARDMAN, P. & BURKITT, M.J. (2003). Evidence for the role of a peroxidase compound I-type intermediate in the oxidation of glutathione, NADH, ascorbate, and dichlorofluorescin by cytochrome c/H2O2. Implications for oxidative stress during apoptosis. J. Biol. Chem., 278, 2941029419.
  • LAWSON, J.A., ROKACH, J. & FITZGERALD, G.A. (1999). Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo. J. Biol. Chem., 274, 2444124444.
  • LE CURIEUX, F. & HEMMINKI, K. (2001). Cyclobutane thymidine dimers are present in human urine following sun exposure: quantitation using 32P-postlabeling and high-performance liquid chromatography. J. Invest. Dermatol., 117, 263268.
  • LEBEL, C.P., ISCHIROPOULOS, H. & BONDY, S.C. (1992). Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol., 5, 227231.
  • LEE, C.K., ALLISON, D.B., BRAND, J., WEINDRUCH, R. & PROLLA, T.A. (2002a). Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc. Natl. Acad. Sci. U.S.A., 99, 1498814993.
  • LEE, J.M., NILES, J.C., WISHNOK, J.S. & TANNENBAUM, S.R. (2002b). Peroxynitrite reacts with 8-nitropurines to yield 8-oxopurines. Chem. Res. Toxicol., 15, 714.
  • LEE, M., HYUN, D.H., HALLIWELL, B. & JENNER, P. (2001). Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4-hydroxynonenal or serum deprivation: potentiation of injury by ALS-related mutant superoxide dismutases and protection by Bcl-2. J. Neurochem., 78, 209220.
  • LEEUWENBURGH, C., HANSEN, P.A., HOLLOSZY, J.O. & HEINECKE, J.W. (1999a). Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine. Free Radic. Biol. Med., 27, 186192.
  • LEEUWENBURGH, C., HANSEN, P.A., HOLLOSZY, J.O. & HEINECKE, J.W. (1999b). Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo. Am. J. Physiol., 276, R128135.
  • LEONARDUZZI, G., SOTTERO, B. & POLI, G. (2002). Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review). J. Nutr. Biochem., 13, 700710.
  • LEVINE, M., WANG, Y., PADAYATTY, S.J. & MORROW, J. (2001). A new recommended dietary allowance of vitamin C for healthy young women. Proc. Natl. Acad. Sci. U.S.A., 98, 98429846.
  • LEVINE, R.L. (2002). Carbonyl modified proteins in cellular regulation, aging, and disease. Free Radic. Biol. Med., 32, 790796.
  • LEVINE, R.L., BERLETT, B.S., MOSKOVITZ, J., MOSONI, L. & STADTMAN, E.R. (1999). Methionine residues may protect proteins from critical oxidative damage. Mech. Ageing Dev., 107, 323332.
  • LI, H., LAWSON, J.A., REILLY, M., ADIYAMAN, M., HWANG, S.W., ROKACH, J. & FITZGERALD, G.A. (1999). Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F2-isoprostanes in human urine. Proc. Natl. Acad. Sci. U.S.A., 96, 1338113386.
  • LI, M., CARLSON, S., KINZER, J.A. & PERPALL, H.J. (2003). HPLC and LC–MS studies of hydroxylation of phenylalanine as an assay for hydroxyl radicals generated from Udenfriend's reagent. Biochem. Biophys. Res. Commun., 312, 316322.
  • LIM, D.G., SWEENEY, S., BLOODSWORTH, A., WHITE, C.R., CHUMLEY, P.H., KRISHNA, N.R., SCHOPFER, F., O'DONNELL, V.B., EISERICH, J.P. & FREEMAN, B.A. (2002). Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity. Proc. Natl. Acad. Sci. U.S.A., 99, 1594115946.
  • LIMA, E.S., DI MASCIO, P. & ABDALLA, D.S. (2003). Cholesteryl nitrolinoleate, a nitrated lipid present in human blood plasma and lipoproteins. J. Lipid. Res., 44, 16601666.
  • LIMA, E.S., DI MASCIO, P., RUBBO, H. & ABDALLA, D.S. (2002). Characterization of linoleic acid nitration in human blood plasma by mass spectrometry. Biochemistry, 41, 1071710722.
  • LIN, H.S., JENNER, A., ONG, C.N., HUANG, S.H., WHITEMAN, M. & HALLIWELL, B. (2004). High-throughput and sensitive methodology for the quantitation of urinary 8OHdG; measurement with GC–MS after single solid phase extraction. Biochem. J., (in press).
  • LIU, J., YEO, H.C., DONIGER, S.J. & AMES, B.N. (1997b). Assay of aldehydes from lipid peroxidation: gas chromatography–mass spectrometry compared to thiobarbituric acid. Anal. Biochem., 245, 161166.
  • LIU, K.J., MIYAKE, M., PANZ, T. & SWARTZ, H. (1999). Evaluation of DEPMPO as a spin trapping agent in biological systems. Free Radic. Biol. Med., 26, 714721.
  • LIU, L., LEECH, J.A., URCH, R.B. & SILVERMAN, F.S. (1997a). In vivo salicylate hydroxylation: a potential biomarker for assessing acute ozone exposure and effects in humans. Am. J. Respir. Crit. Care Med., 156, 14051412.
  • LIU, Q., RAINA, A.K., SMITH, M.A., SAYRE, L.M. & PERRY, G. (2003). Hydroxynonenal, toxic carbonyls, and Alzheimer disease. Mol. Aspects Med., 24, 305313.
  • LONG, L.H., CLEMENT, M.V. & HALLIWELL, B. (2000). Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (−)-epigallocatechin, (−)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem. Biophys. Res. Commun., 273, 5053.
  • LONG, L.H., EVANS, P.J. & HALLIWELL, B. (1999). Hydrogen peroxide in human urine: implications for antioxidant defense and redox regulation. Biochem. Biophys. Res. Commun., 262, 605609.
  • LONG, L.H. & HALLIWELL, B. (2000). Coffee drinking increases levels of urinary hydrogen peroxide detected in healthy human volunteers. Free Radic. Res., 32, 463467.
  • LONG, L.H. & HALLIWELL, B. (2001). Oxidation and generation of hydrogen peroxide by thiol compounds in commonly used cell culture media. Biochem. Biophys. Res. Commun., 286, 991994.
  • LUBEC, G., WIDNESS, J.A., HAYDE, M., MENZEL, D. & POLLAK, A. (1997). Hydroxyl radical generation in oxygen-treated infants. Pediatrics, 100, 700704.
  • LYNCH, R.E. & FRIDOVICH, I. (1978). Permeation of the erythrocyte stroma by superoxide radical. J. Biol. Chem., 253, 46974699.
  • MACMILLAN-CROW, L.A., CROW, J.P., KERBY, J.D., BECKMAN, J.S. & THOMPSON, J.A. (1996). Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. Proc. Natl. Acad. Sci. U.S.A., 93, 1185311858.
  • MACPHERSON, J.C., COMHAIR, S.A., ERZURUM, S.C., KLEIN, D.F., LIPSCOMB, M.F., KAVURU, M.S., SAMOSZUK, M.K. & HAZEN, S.L. (2001). Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species. J. Immunol., 166, 57635772.
  • MALLAT, Z., PHILIP, I., LEBRET, M., CHATEL, D., MACLOUF, J. & TEDGUI, A. (1998). Elevated levels of 8-iso-prostaglandin F2 in pericardial fluid of patients with heart failure: a potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure. Circulation, 97, 15361539.
  • MANARY, M.J., LEEUWENBURGH, C. & HEINECKE, J.W. (2000). Increased oxidative stress in kwashiorkor. J. Pediatr., 137, 421424.
  • MANI, A.R., PANNALA, A.S., ORIE, N.N., OLLOSSON, R., HARRY, D., RICE-EVANS, C.A. & MOORE, K.P. (2003). Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine. Biochem. J., 374, 521527.
  • MANNICK, J.B. & SCHONHOFF, C. (2004). NO means no and yes: regulation of cell signaling by protein nitrosylation. Free Radic. Res., 38, 17.
  • MARCHESI, E., ROTA, C., FANN, Y.C., CHIGNELL, C.F. & MASON, R.P. (1999). Photoreduction of the fluorescent dye 2′-7′-dichlorofluorescein: a spin trapping and direct electron spin resonance study with implications for oxidative stress measurements. Free Radic. Biol. Med., 26, 148161.
  • MARKLUND, N., OSTMAN, B., NALMO, L., PERSSON, L. & HILLERED, L. (2000). Hypoxanthine, uric acid and allantoin as indicators of in vivo free radical reactions. Description of a HPLC method and human brain microdialysis data. Acta Neurochir., 142, 11351142.
  • MARLA, S.S., LEE, J. & GROVES, J.T. (1997). Peroxynitrite rapidly permeates phospholipid membranes. Proc. Natl. Acad. Sci. U.S.A., 94, 1424314248.
  • MARNETT, L.J., RIGGINS, J.N. & WEST, J.D. (2003). Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. J. Clin. Invest., 111, 583593.
  • MARTIN, B.D., SCHOENHARD, J.A. & SUGDEN, K.D. (1998). Hypervalent chromium mimics reactive oxygen species as measured by the oxidant-sensitive dyes 2′,7′-dichlorofluorescin and dihydrorhodamine. Chem. Res. Toxicol., 11, 14021410.
  • MAY, J.M. (2000). How does ascorbic acid prevent endothelial dysfunction? Free Radic. Biol. Med., 28, 14211429.
  • MAY, J.M., QU, Z. & COBB, C.E. (2001). Recycling of the ascorbate free radical by human erythrocyte membranes. Free Radic. Biol. Med., 31, 117124.
  • MEAGHER, E.A., BARRY, O.P., LAWSON, J.A., ROKACH, J. & FITZGERALD, G.A. (2001). Effects of vitamin E on lipid peroxidation in healthy persons. JAMA, 285, 11781182.
  • MEIJER, E.P., COOLEN, S.A., BAST, A. & WESTERTERP, K.R. (2001). Exercise training and oxidative stress in the elderly as measured by antipyrine hydroxylation products. Free Radic. Res., 35, 435443.
  • MEISTER, A. & ANDERSON, M.E. (1983). Glutathione. Annu. Rev. Biochem., 52, 711760.
  • MIKAMI, T., KITA, K., TOMITA, S., QU, G.J., TASAKI, Y. & ITO, A. (2000). Is allantoin in serum and urine a useful indicator of exercise-induced oxidative stress in humans? Free Radic. Res., 32, 235244.
  • MINAMIKAWA, T., SRIRATANA, A., WILLIAMS, D.A., BOWSER, D.N., HILL, J.S. & NAGLEY, P. (1999). Chloromethyl-X-rosamine (MitoTracker Red) photosensitises mitochondria and induces apoptosis in intact human cells. J. Cell Sci., 112, 24192430.
  • MOISON, R.M., DE BEAUFORT, A.J., HAASNOOT, A.A., DUBBELMAN, T.M., VAN ZOEREN-GROBBEN, D. & BERGER, H.M. (1997). Uric acid and ascorbic acid redox ratios in plasma and tracheal aspirate of preterm babies with acute and chronic lung disease. Free Radic. Biol. Med., 23, 226234.
  • MOLLER, P. & LOFT, S. (2002). Oxidative DNA damage in human white blood cells in dietary antioxidant intervention studies. Am. J. Clin. Nutr., 76, 303310.
  • MONTINE, T.J., MARKESBERY, W.R., MORROW, J.D. & ROBERTS II, L.J. (1998). Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease. Ann. Neurol., 44, 410413.
  • MONTINE, T.J., MARKESBERY, W.R., ZACKERT, W., SANCHEZ, S.C., ROBERTS II, L.J. & MORROW, J.D. (1999). The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients. Am. J. Pathol., 155, 863868.
  • MONTINE, T.J., QUINN, J.F., MILATOVIC, D., SILBERT, L.C., DANG, T., SANCHEZ, S., TERRY, E., ROBERTS II, L.J., KAYE, J.A. & MORROW, J.D. (2002). Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Ann. Neurol., 52, 175179.
  • MONTUSCHI, P., CORRADI, M., CIABATTONI, G., NIGHTINGALE, J., KHARITONOV, S.A. & BARNES, P.J. (1999). Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Am. J. Respir. Crit. Care Med., 160, 216220.
  • MORIN, B., BUBB, W.A., DAVIES, M.J., DEAN, R.T. & FU, S. (1998). 3-Hydroxylysine, a potential marker for studying radical-induced protein oxidation. Chem. Res. Toxicol., 11, 12651273.
  • MORROW, J.D. (2003). Is oxidant stress a connection between obesity and atherosclerosis? Arterioscler. Thromb. Vasc. Biol., 23, 368370.
  • MORROW, J.D., ROBERTS, L.J., DANIEL, V.C., AWAD, J.A., MIROCHNITCHENKO, O., SWIFT, L.L. & BURK, R.F. (1998). Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo– effects of oxygen tension and glutathione. Arch. Biochem. Biophys., 353, 160171.
  • MORTON, L.W., PUDDEY, I.B. & CROFT, K.D. (2003). Comparison of nitration and oxidation of tyrosine in advanced human carotid plaque proteins. Biochem. J., 370, 339344.
  • MUNZEL, T., AFANAS'EV, I.B., KLESCHYOV, A.L. & HARRISON, D.G. (2002). Detection of superoxide in vascular tissue. Arterioscler. Thromb. Vasc. Biol., 22, 17611768.
  • MURPHEY, L.J., MORROW, J.D., SAWATHIPARNICH, P., WILLIAMS, G.H., VAUGHAN, D.E. & BROWN, N.J. (2003). Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives. Free Radic. Biol. Med., 35, 711718.
  • MYHRE, O., ANDERSEN, J.M., AARNES, H. & FONNUM, F. (2003). Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem. Pharmacol., 65, 15751582.
  • NAIR, U.J., NAIR, J., FRIESEN, M.D., BARTSCH, H. & OHSHIMA, H. (1995). Ortho- and meta-tyrosine formation from phenylalanine in human saliva as a marker of hydroxyl radical generation during betel quid chewing. Carcinogenesis, 16, 11951198.
  • NELSON, G.J., MORRIS, V.C., SCHMIDT, P.C. & LEVANDER, O. (1993). The urinary excretion of thiobarbituric acid reactive substances and malondialdehyde by normal adult males after consuming a diet containing salmon. Lipids, 28, 757761.
  • NIELSEN, S.E., YOUNG, J.F., DANESHVAR, B., LAURIDSEN, S.T., KNUTHSEN, P., SANDSTROM, B. & DRAGSTED, L.O. (1999). Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects. Br. J. Nutr., 81, 447455.
  • NOUROOZ-ZADEH, J., HALLIWELL, B. & ANGGARD, E.E. (1997). Evidence for the formation of F3-isoprostanes during peroxidation of eicosapentaenoic acid. Biochem. Biophys. Res. Commun., 236, 467472.
  • NOUROOZ-ZADEH, J., LIU, E.H., YHLEN, B., ANGGARD, E.E. & HALLIWELL, B. (1999). F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. J. Neurochem., 72, 734740.
  • OGIHARA, T., HIRANO, K., OGIHARA, H., MISAKI, K., HIROI, M., MORINOBU, T., KIM, H.S., OGAWA, S., BAN, R., HASEGAWA, M. & TAMAI, H. (2003). Non-protein-bound transition metals and hydroxyl radical generation in cerebrospinal fluid of newborn infants with hypoxic ischemic encephalopathy. Pediatr. Res., 53, 594599.
  • OGIHARA, T., KIM, H.S., HIRANO, K., IMANISHI, M., OGIHARA, H., TAMAI, H., OKAMOTO, R. & MINO, M. (1998). Oxidation products of uric acid and ascorbic acid in preterm infants with chronic lung disease. Biol. Neonate, 73, 2433.
  • OGINO, K., NAKAJIMA, M., KODAMA, N., KUBO, M., KIMURA, S., NAGASE, H. & NAKAMURA, H. (2002). Immunohistochemical artifact for nitrotyrosine in eosinophils or eosinophil containing tissue. Free Radic. Res., 36, 11631170.
  • OHASHI, T., MIZUTANI, A., MURAKAMI, A., KOJO, S., ISHII, T. & TAKETANI, S. (2002). Rapid oxidation of dichlorodihydrofluorescin with heme and hemoproteins: formation of the fluorescein is independent of the generation of reactive oxygen species. FEBS Lett., 511, 2127.
  • OHSHIMA, H., FRIESEN, M., BROUET, I. & BARTSCH, H. (1990). Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins. Food Chem. Toxicol., 28, 647652.
  • OIKAWA, S. & KAWANISHI, S. (1999). Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett., 453, 365368.
  • OLDREIVE, C. & RICE-EVANS, C. (2001). The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: impact of diet. Free Radic. Res., 35, 215231.
  • O'MALLEY, Y.Q., RESZKA, K.J. & BRITIGAN, B.E. (2004). Direct oxidation of 2′,7′-dichlorodihydrofluorescein by pyocyanin and other redox-active compounds independent of reactive oxygen species production. Free Radic. Biol. Med., 36, 90100.
  • ONG, W.Y. & HALLIWELL, B. (2004). Iron, atherosclerosis and neurodegeneration. A key role for cholesterol in promoting iron-dependent oxidative damage? Ann. NY Acad. Sci., (in press).
  • ONG, W.Y., LU, X.R., HU, C.Y. & HALLIWELL, B. (2000). Distribution of hydroxynonenal-modified proteins in the kainate-lesioned rat hippocampus: evidence that hydroxynonenal formation precedes neuronal cell death. Free Radic. Biol. Med., 28, 12141221.
  • OSTDAL, H., DAVIES, M.J. & ANDERSEN, H.J. (2002). Reaction between protein radicals and other biomolecules. Free Radic. Biol. Med., 33, 201209.
  • OTTENEDER, M., SCOTT DANIELS, J., VOEHLER, M. & MARNETT, L.J. (2003). Development of a method for determination of the malondialdehyde–deoxyguanosine adduct in urine using liquid chromatography–tandem mass spectrometry. Anal. Biochem., 315, 147151.
  • PALOMBA, L., SESTILI, P., GUIDARELLI, A., SCIORATI, C., CLEMENTI, E., FIORANI, M. & CANTONI, O. (2000). Products of the phospholipase A2 pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells. Free Radic. Biol. Med., 29, 783789.
  • PANTKE, U., VOLK, T., SCHMUTZLER, M., KOX, W.J., SITTE, N. & GRUNE, T. (1999). Oxidized proteins as a marker of oxidative stress during coronary heart surgery. Free Radic. Biol. Med., 27, 10801086.
  • PARTHASARATHY, S., SANTANAM, N., RAMACHANDRAN, S. & MEILHAC, O. (2000). Potential role of oxidized lipids and lipoproteins in antioxidant defense. Free Radic. Res., 33, 197215.
  • PAVITT, D.V., DE FONSEKA, S., AL-KHALAF, N., CAM, J.M. & REAVELEY, D.A. (2002). Assay of serum allantoin in humans by gas chromatography–mass spectrometry. Clin. Chim. Acta, 318, 6370.
  • PENNATHUR, S., WAGNER, J.D., LEEUWENBURGH, C., LITWAK, K.N. & HEINECKE, J.W. (2001). A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. J. Clin. Invest., 107, 853860.
  • PETRAT, F., PINDIUR, S., KIRSCH, M. & GROOT, H. (2003). NAD(P)H, a primary target of 1O2 in mitochondria of intact cells. J. Biol. Chem., 278, 32983307.
  • PHILLIPS, M., GREENBERG, J. & CATANEO, R.N. (2000). Effect of age on the profile of alkanes in normal human breath. Free Radic. Res., 33, 5763.
  • PI, J., HORIGUCHI, S., SUN, Y., NIKAIDO, M., SHIMOJO, N., HAYASHI, T., YAMAUCHI, H., ITOH, K., YAMAMOTO, M., SUN, G., WAALKES, M.P. & KUMAGAI, Y. (2003). A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits. Free Radic. Biol. Med., 35, 102113.
  • PIETRI, S., LIEBGOTT, T., FREJAVILLE, C., TORDO, P. & CULCASI, M. (1998). Nitrone spin traps and their pyrrolidine analogs in myocardial reperfusion injury: hemodynamic and ESR implications – evidence for a cardioprotective phosphonate effect for 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide in rat hearts. Eur. J. Biochem., 254, 256265.
  • PILGER, A., IVANCSITS, S., GERMADNIK, D. & RUDIGER, H.W. (2002). Urinary excretion of 8-hydroxy-2′-deoxyguanosine measured by high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 778, 393401.
  • PINLAOR, S., YONGVANIT, P., HIRAKU, Y., MA, N., SEMBA, R., OIKAWA, S., MURATA, M., SRIPA, B., SITHITHAWORN, P. & KAWANISHI, S. (2003). 8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini. Biochem. Biophys. Res. Commun., 309, 567571.
  • PLEINER, J., MITTERMAYER, F., SCHALLER, G., MACALLISTER, R.J. & WOLZT, M. (2002). High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm. Circulation, 106, 14601464.
  • PLOTNICK, G.D., CORRETTI, M.C. & VOGEL, R.A. (1997). Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA, 278, 16821686.
  • POU, S., HUANG, Y.I., BHAN, A., BHADTI, V.S., HOSMANE, R.S., WU, S.Y., CAO, G.L. & ROSEN, G.M. (1993). A fluorophore-containing nitroxide as a probe to detect superoxide and hydroxyl radical generated by stimulated neutrophils. Anal. Biochem., 212, 8590.
  • PRATICO, D., CLARK, C.M., LEE, V.M., TROJANOWSKI, J.Q., ROKACH, J. & FITZGERALD, G.A. (2000). Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity. Ann. Neurol., 48, 809812.
  • PRATICO, D., CLARK, C.M., LIUN, F., ROKACH, J., LEE, V.Y. & TROJANOWSKI, J.Q. (2002). Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch. Neurol., 59, 972976.
  • PRATICO, D., URYU, K., LEIGHT, S., TROJANOSWKI, J.Q. & LEE, V.M. (2001). Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J. Neurosci., 21, 41834187.
  • PRIOR, R.L. & CAO, G. (1999). In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic. Biol. Med., 27, 11731181.
  • PROUDFOOT, J., BARDEN, A., MORI, T.A., BURKE, V., CROFT, K.D., BEILIN, L.J. & PUDDEY, I.B. (1999). Measurement of urinary F(2)-isoprostanes as markers of in vivo lipid peroxidation – a comparison of enzyme immunoassay with gas chromatography/mass spectrometry. Anal. Biochem., 272, 209215.
  • PUGLIELLI, L., TANZI, R.E. & KOVACS, D.M. (2003). Alzheimer's disease: the cholesterol connection. Nat. Neurosci., 6, 345351.
  • RADI, R., PELUFFO, G., ALVAREZ, M.N., NAVILIAT, M. & CAYOTA, A. (2001). Unraveling peroxynitrite formation in biological systems. Free Radic. Biol. Med., 30, 463488.
  • RAHMAN, I. & KELLY, F. (2003). Biomarkers in breath condensate: a promising new non-invasive techique in free radical research. Free Radic. Res., 37, 12531266.
  • RAVANAT, J.L., GUICHERD, P., TUCE, Z. & CADET, J. (1999). Simultaneous determination of five oxidative DNA lesions in human urine. Chem. Res. Toxicol., 12, 802808.
  • REDDY, S., HALLIWELL, B., JONES, A.D. & LONGHURST, J.C. (1999). The use of phenylalanine to detect hydroxyl radical production in vivo: a cautionary note. Free Radic. Biol. Med., 27, 1465.
  • REFOLO, L.M., PAPPOLLA, M.A., LAFRANCOIS, J., MALESTER, B., SCHMIDT, S.D., THOMAS-BRYANT, T., TINT, G.S., WANG, R., MERCKEN, M., PETANCESKA, S.S. & DUFF, K.E. (2001). A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis., 8, 890899.
  • REICH, E.E., MARKESBERY, W.R., ROBERTS II, L.J., SWIFT, L.L., MORROW, J.D. & MONTINE, T.J. (2001). Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. Am. J. Pathol., 158, 293297.
  • REQUENA, J.R., CHAO, C.C., LEVINE, R.L. & STADTMAN, E.R. (2001). Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proc. Natl. Acad. Sci. U.S.A., 98, 6974.
  • RETH, M. (2002). Hydrogen peroxide as second messenger in lymphocyte activation. Nat. Immunol., 3, 11291134.
  • REY, F.E. & PAGANO, P.J. (2002). The reactive adventitia: fibroblast oxidase in vascular function. Arterioscler. Thromb. Vasc. Biol., 22, 19621971.
  • REZNICK, A.Z., CROSS, C.E., HU, M.L., SUZUKI, Y.J., KHWAJA, S., SAFADI, A., MOTCHNIK, P.A., PACKER, L. & HALLIWELL, B. (1992). Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation. Biochem. J., 286, 607611.
  • RICE-EVANS, C.A. (2000). Measurement of total antioxidant activity as a marker of antioxidant status in vivo: procedures and limitations. Free Radic. Res., 33 (Suppl), S59S66.
  • RICHELLE, M., TURINI, M.E., GUIDOUX, R., TAVAZZI, I., METAIRON, S. & FAY, L.B. (1999). Urinary isoprostane excretion is not confounded by the lipid content of the diet. FEBS Lett., 459, 259262.
  • RITOV, V.B., BANNI, S., YALOWICH, J.C., DAY, B.W., CLAYCAMP, H.G., CORONGIU, F.P. & KAGAN, V.E. (1996). Non-random peroxidation of different classes of membrane phospholipids in live cells detected by metabolically integrated cis-parinaric acid. Biochim. Biophys. Acta, 1283, 127140.
  • RIUS, M., NIES, A.T., HUMMEL-EISENBEISS, J., JEDLITSCHKY, G. & KEPPLER, D. (2003). Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology, 38, 374384.
  • RIZZI, C., SAMOUILOV, A., KUTALA, V.K., PARINANDI, N.L., ZWEIER, J.L. & KUPPUSAMY, P. (2003). Application of a trityl-based radical probe for measuring superoxide. Free Radic. Biol. Med., 35, 16081618.
  • ROBERTS, C.K., VAZIRI, N.D. & BARNARD, R.J. (2002). Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, and nitric oxide availability. Circulation, 106, 25302532.
  • ROBERTS II, L.J. & MORROW, J.D. (2002). Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation. Cell. Mol. Life Sci., 59, 808820.
  • RODRIGUEZ, H., AKMAN, S.A., HOLMQUIST, G.P., WILSON, G.L., DRIGGERS, W.J. & LEDOUX, S.P. (2000). Mapping oxidative DNA damage using ligation-mediated polymerase chain reaction technology. Methods, 22, 148156.
  • ROQUES, S.C., LANDRAULT, N., TEISSEDRE, P.L., LAURENT, C., BESANCON, P., ROUANE, J.M. & CAPORICCIO, B. (2002). Hydrogen peroxide generation in caco-2 cell culture medium by addition of phenolic compounds: effect of ascorbic acid. Free Radic. Res., 36, 593599.
  • ROSEN, G.M., BRITIGAN, B., HALPERN, H. & POU, S. (1999). Free Radicals. Biology and Detection by Spin Trapping. Oxford, U.K.: Oxford University Press.
  • ROTA, C., FANN, Y.C. & MASON, R.P. (1999). Phenoxyl free radical formation during the oxidation of the fluorescent dye 2′,7′-dichlorofluorescein by horseradish peroxidase. Possible consequences for oxidative stress measurements. J. Biol. Chem., 274, 2816128168.
  • ROZALSKI, R., WINKLER, P., GACKOWSKI, D., PACIOREK, T., KASPRZAK, H. & OLINSKI, R. (2003). High concentrations of excised oxidative DNA lesions in human cerebrospinal fluid. Clin. Chem., 49, 12181221.
  • RUSSELL, A.P., GASTALDI, G., BOBBIONI-HARSCH, E., ARBOIT, P., GOBELET, C., DERIAZ, O., GOLAY, A., WITZTUM, J.L. & GIACOBINO, J.P. (2003). Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids? FEBS Lett., 551, 104106.
  • SAKHAROV, D.V., BUNSCHOTEN, A., VAN WEELDEN, H. & WIRTZ, K.W.A. (2003). Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation. Eur. J. Biochem., 270, 48594865.
  • SAMPSON, M.J., GOPAUL, N., DAVIES, I.R., HUGHES, D.A. & CARRIER, M.J. (2002). Plasma F2 isoprostanes: direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes. Diabetes Care, 25, 537541.
  • SAMUELSSON, L., GOTTSATER, A. & LINDGARDE, F. (2003). Decreasing levels of tumour necrosis factor alpha and interleukin 6 during lowering of body mass index with orlistat or placebo in obese subjects with cardiovascular risk factors. Diabetes Obes. Metab., 5, 195201.
  • SARVAZYAN, N., SWIFT, L. & MARTINEZ-ZAGUILAN, R. (1998). Effects of oxidants on properties of fluorescent calcium indicators. Arch. Biochem. Biophys., 350, 132136.
  • SAWYER, D.E., MERCER, B.G., WIKLENDT, A.M. & AITKEN, R.J. (2003). Quantitative analysis of gene-specific DNA damage in human spermatozoa. Mutat. Res., 529, 2134.
  • SCHLESIER, K., HARWAT, M., BOHM, V. & BITSCH, R. (2002). Assessment of antioxidant activity by using different in vitro methods. Free Radic. Res., 36, 177187.
  • SCHOCK, B.C., SWEET, D.G., HALLIDAY, H.L., YOUNG, I.S. & ENNIS, M. (2001). Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease. Am. J. Physiol. Lung Cell Mol. Physiol., 281, L13861391.
  • SETSUKINAI, K., URANO, Y., KAKINUMA, K., MAJIMA, H.J. & NAGANO, T. (2003). Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J. Biol. Chem., 278, 31703175.
  • SHACTER, E., WILLIAMS, J.A., LIM, M. & LEVINE, R.L. (1994). Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay. Free Radic. Biol. Med., 17, 429437.
  • SHARMA, M.K. & BUETTNER, G.R. (1993). Interaction of vitamin C and vitamin E during free radical stress in plasma: an ESR study. Free Radic. Biol. Med., 14, 649653.
  • SHARMA, M.K., BUETTNER, G.R., SPENCER, K.T. & KERBER, R.E. (1994). Ascorbyl free radical as a real-time marker of free radical generation in briefly ischemic and reperfused hearts. An electron paramagnetic resonance study. Circ. Res., 74, 650658.
  • SHAROV, V.S., FERRINGTON, D.A., SQUIER, T.C. & SCHONEICH, C. (1999). Diastereoselective reduction of protein-bound methionine sulfoxide by methionine sulfoxide reductase. FEBS Lett., 455, 247250.
  • SHIMOI, K., KASAI, H., YOKOTA, N., TOYOKUNI, S. & KINAE, N. (2002). Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2′-deoxyguanosine in human urine. Cancer Epidemiol. Biomarkers Prev., 11, 767770.
  • SHISHEHBOR, M.H., BRENNAN, M.L., AVILES, R.J., FU, X., PENN, M.S., SPRECHER, D.L. & HAZEN, S.L. (2003). Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation, 108, 426431.
  • SHVEDOVA, A.A., TYURINA, J.Y., KAWAI, K., TYURIN, V.A., KOMMINENI, C., CASTRANOVA, V., FABISIAK, J.P. & KAGAN, V.E. (2002). Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide. J. Invest. Dermatol., 118, 10081018.
  • SIES, H. (1991). Oxidative Stress: Oxidants and Antioxidants. New York: Academic Press.
  • SIM, Y.E. & STACEY, M.C. (2003). Iron and 8-isoprostane levels in acute and chronic wounds. J. Invest. Dermatol., 121, 918925.
  • SINGH, N., GRAVES, J., TAYLOR, P.D., MACALLISTER, R.J. & SINGER, D.R. (2002). Effects of a ‘healthy’ diet and of acute and long-term vitamin C on vascular function in healthy older subjects. Cardiovasc. Res., 56, 118125.
  • SOHAL, R.S., MOCKETT, R.J. & ORR, W.C. (2002). Mechanisms of aging: an appraisal of the oxidative stress hypothesis. Free Radic. Biol. Med., 33, 575586.
  • SOHN, H.Y., KELLER, M., GLOE, T., CRAUSE, P. & POHL, U. (2000). Pitfalls of using lucigenin in endothelial cells: implications for NAD(P)H dependent superoxide formation. Free Radic. Res., 32, 265272.
  • SPASOJEVIC, I., LIOCHEV, S.I. & FRIDOVICH, I. (2000). Lucigenin: redox potential in aqueous media and redox cycling with O2•− production. Arch. Biochem. Biophys., 373, 447450.
  • SPENCER, J.P., JENNER, A., ARUOMA, O.I., CROSS, C.E., WU, R. & HALLIWELL, B. (1996a). Oxidative DNA damage in human respiratory tract epithelial cells. Time course in relation to DNA strand breakage. Biochem. Biophys. Res. Commun., 224, 1722.
  • SPENCER, J.P., WONG, J., JENNER, A., ARUOMA, O.I., CROSS, C.E. & HALLIWELL, B. (1996b). Base modification and strand breakage in isolated calf thymus DNA and in DNA from human skin epidermal keratinocytes exposed to peroxynitrite or 3-morpholinosydnonimine. Chem. Res. Toxicol., 9, 11521158.
  • STEINBERG, D. & WITZTUM, J.L. (2002). Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation, 105, 21072111.
  • STOLZE, K., UDILOVA, N., ROSENAU, T., HOFINGER, A. & NOHL, H. (2003). Spin trapping of superoxide, alky- and lipid-derived radicals with derivatives of the spin trap EPPN. Biochem. Pharmacol., 66, 17171726.
  • SUBRAMANIAM, R., FAN, X.J., SCIVITTARO, V., YANG, J., HA, C.E., PETERSEN, C.E., SUREWICZ, W.K., BHAGAVAN, N.V., WEISS, M.F. & MONNIER, V.M. (2002). Cellular oxidant stress and advanced glycation endproducts of albumin: caveats of the dichlorofluorescein assay. Arch. Biochem. Biophys., 400, 1525.
  • SUN, J.Z., KAUR, H., HALLIWELL, B., LI, X.Y. & BOLLI, R. (1993). Use of aromatic hydroxylation of phenylalanine to measure production of hydroxyl radicals after myocardial ischemia in vivo. Direct evidence for a pathogenetic role of the hydroxyl radical in myocardial stunning. Circ. Res., 73, 534549.
  • SVETKEY, L.P. & LORIA, C.M. (2002). Blood pressure effects of vitamin C: what's the key question? Hypertension, 40, 789791.
  • TAKAHASHI, M., SHIBATA, M. & NIKI, E. (2001). Estimation of lipid peroxidation of live cells using a fluorescent probe, diphenyl-1-pyrenylphosphine. Free Radic. Biol. Med., 31, 164174.
  • TAMPO, Y., KOTAMRAJU, S., CHITAMBAR, R.C., KALIVENDI, S.V., KESZLER, A., JOESPH, J. & KALYANARAMAN, B. (2003). Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endotheliel cells. Role of transferrin receptor-dependent iron uptake in apoptois. Circ. Res., 92, 5663.
  • TANAKA, T., WADA, K., YAMAMORI, H., TANAKA, S., KUDO, T. & TAKEDA, M. (2003). Biological markers for Alzheimer disease. Seishin Shinkeigaku Zasshi, 105, 387392.
  • TARKKA, M.R., VUOLLE, M., KAUKINEN, S., HOLM, P., ELORANTA, J., KAUKINEN, U., SISTO, T. & KATAJA, J. (2000). Effect of allopurinol on myocardial oxygen free radical production in coronary bypass surgery. Scand. Cardiovasc. J., 34, 593596.
  • TARPEY, M.M., WHITE, C.R., SUAREZ, E., RICHARDSON, G., RADI, R. & FREEMAN, B.A. (1999). Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation. Circ. Res., 84, 12031211.
  • THEMANN, C., TEISMANN, P., KUSCHINSKY, K. & FERGER, B. (2001). Comparison of two independent aromatic hydroxylation assays in combination with intracerebral microdialysis to determine hydroxyl free radicals. J. Neurosci. Methods, 108, 5764.
  • THOME, J., ZHANG, J., DAVIDS, E., FOLEY, P., WEIJERS, H.G., WIESBECK, G.A., BONING, J., RIEDERER, P. & GERLACH, M. (1997). Evidence for increased oxidative stress in alcohol-dependent patients provided by quantification of in vivo salicylate hydroxylation products. Alcohol Clin. Exp. Res., 21, 8285.
  • THUKKANI, A.K., MCHOWAT, J., HSU, F.F., BRENNAN, M.L., HAZEN, S.L. & FORD, D.A. (2003). Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic Lesions. Circulation, 108, 31283133.
  • TOYOKUNI, S., TANAKA, T., HATTORI, Y., NISHIYAMA, Y., YOSHIDA, A., UCHIDA, K., HIAI, H., OCHI, H. & OSAWA, T. (1997). Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab. Invest., 76, 365374.
  • TUBARO, M., CAVALLO, G., PENSA, V., CHESSA, M.A., NATALE, E., RICCI, R., MILAZZOTTO, F. & TUBARO, E. (1992). Demonstration of the formation of hydroxyl radicals in acute myocardial infarction in man using salicylate as probe. Cardiology, 80, 246251.
  • UCHIDA, K. (1999). Current status of acrolein as a lipid peroxidation product. Trends Cardiovasc. Med., 9, 109113.
  • UCHIDA, K. (2003). 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog. Lipid Res., 42, 318343.
  • UCHIDA, K. & KAWAKISHI, S. (1993). 2-Oxo-histidine as a novel biological marker for oxidatively modified proteins. FEBS Lett., 332, 208210.
  • UKAMOTO, M. & YONAHA, M. (1998). The antioxidant action of 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-alpha]pyra z in-3-one (MCLA), a chemiluminescence probe to detect superoxide anions. FEBS Lett., 430, 348352.
  • ULUS, A.T., AKSOYEK, A., OZKAN, M., KATIRCIOGLU, S.F. & BASU, S. (2003). Cardiopulmonary bypass as a cause of free radical-induced oxidative stress and enhanced blood-borne isoprostanes in humans. Free Radic. Biol. Med., 34, 911917.
  • UTSUMI, H. & YAMADA, K. (2003). In vivo electron spin resonance-computed tomography/nitroxyl probe technique for non-invasive analysis of oxidative injuries. Arch. Biochem. Biophys., 416, 18.
  • VALGIMIGLI, M., VALGIMIGLI, L., TRERE, D., GAIANI, S., PEDULLI, G.F., GRAMANTIERI, L. & BOLONDI, L. (2002). Oxidative stress EPR measurement in human liver by radical-probe technique. Correlation with etiology, histology and cell proliferation. Free Radic. Res., 36, 939948.
  • VARMA, S.D. & DEVAMANOHARAN, P.S. (1990). Excretion of hydrogen peroxide in human urine. Free Radic. Res. Commun., 8, 7378.
  • WARDMAN, P., BURKITT, M.J., PATEL, K.B., LAWRENCE, A., JONES, C.M., EVERETT, S.A. & VOJNOVIC, B. (2002). Pitfalls in the use of common luminescent probes for oxidative and nitrosative stress. J. Fluores, 12, 6568.
  • WEE, L.M., LONG, L.H., WHITEMAN, M. & HALLIWELL, B. (2003). Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's modified Eagles medium. Free Radic. Res., 37, 11231130.
  • WHITEMAN, M. & HALLIWELL, B. (1999). Loss of 3-nitrotyrosine on exposure to hypochlorous acid: implications for the use of 3-nitrotyrosine as a bio-marker in vivo. Biochem. Biophys. Res. Commun., 258, 168172.
  • WHITEMAN, M., HONG, H.S., JENNER, A. & HALLIWELL, B. (2002a). Loss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo. Biochem. Biophys. Res. Commun., 296, 883889.
  • WHITEMAN, M., JENNER, A. & HALLIWELL, B. (1997). Hypochlorous acid-induced base modifications in isolated calf thymus DNA. Chem. Res. Toxicol., 10, 12401246.
  • WHITEMAN, M., KETSAWATSAKUL, U. & HALLIWELL, B. (2002b). A reassessment of the peroxynitrite scavenging activity of uric acid. Ann. NY Acad. Sci., 962, 242259.
  • WIDLANSKY, M.E., BIEGELSEN, E.S., HAMBURG, N.M., DUFFY, S.J., KEANEY JR, J.F. & VITA, J.A. (2004). Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid. Free Radic. Biol. Med., 36, 123130.
  • WILKINSON, I.B., MEGSON, I.L., MACCALLUM, H., SOGO, N., COCKCROFT, J.R. & WEBB, D.J. (1999). Oral vitamin C reduces arterial stiffness and platelet aggregation in humans. J. Cardiovasc. Pharmacol., 34, 690693.
  • WILSON, R., LYALL, K., SMYTH, L., FERNIE, C.E. & RIEMERSMA, R.A. (2002). Dietary hydroxy fatty acids are absorbed in humans: implications for the measurement of ‘oxidative stress’in vivo. Free Radic. Biol. Med., 32, 162168.
  • WINTERBOURN, C.C. & KETTLE, A.J. (2000). Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radic. Biol. Med., 29, 403409.
  • WISEMAN, H. & HALLIWELL, B. (1996). Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem. J., 313, 1729.
  • WOLFRUM, S., JENSEN, K.S. & LIAO, J.K. (2003). Endothelium-dependent effects of statins. Arterioscler. Thromb. Vasc. Biol., 23, 729736.
  • WRIGHT, W.E. & SHAY, J.W. (2002). Historical claims and current interpretations of replicative aging. Nat. Biotechnol., 20, 682688.
  • WU, W., CHEN, Y., D'AVIGNON, A. & HAZEN, S.L. (1999). 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo. Biochemistry, 38, 35383548.
  • WU, W., SAMOSZUK, M.K., COMHAIR, S.A., THOMASSEN, M.J., FARVER, C.F., DWEIK, R.A., KAVURU, M.S., ERZURUM, S.C. & HAZEN, S.L. (2000). Eosinophils generate brominating oxidants in allergen-induced asthma. J. Clin. Invest., 105, 14551463.
  • YARDIM-AKAYDIN, S., SEPICI, A., ÖZKAN, Y., TORUN, M., SIMSEK, B. & SEPICI, V. (2004). Oxidation of uric acid in rheumatoid arthritis: is allantoin a marker of oxidative stress? Free Radic. Res., (in press).
  • YERMILOV, V., RUBIO, J. & OHSHIMA, H. (1995). Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination. FEBS Lett., 376, 207210.
  • YOSHIDA, R., OGAWA, Y. & KASAI, H. (2002). Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine values measured by an ELISA correlated well with measurements by high-performance liquid chromatography with electrochemical detection. Cancer Epidemiol. Biomarkers Prev., 11, 10761081.
  • YOSHIDA, Y., SHIMAKAWA, S., ITOH, N. & NIKI, E. (2003). Action of DCFH and BODIPY as a probe for radical oxidation in hydrophilic and lipophilic domain. Free Radic. Res., 37, 861872.
  • YOUNG, J.F., DRAGSTED, L.O., DANESHVAR, B., LAURIDSEN, S.T., HANSEN, M. & SANDSTROM, B. (2000a). The effect of grape-skin extract on oxidative status. Br. J. Nutr., 84, 505513.
  • YOUNG, J.F., NIELSEN, S.E., HARALDSDOTTIR, J., DANESHVAR, B., LAURIDSEN, S.T., KNUTHSEN, P., CROZIER, A., SANDSTROM, B. & DRAGSTED, L.O. (2000b). Polyphenolic antioxidants in fruit juice. Urinary excretion and effects on biological markers for antioxidative status. Ugeskr. Laeg., 162, 13881392.
  • YUEN, J.W.M. & BENZIE, I.F. (2003). Hydrogen peroxide in human urine as a potential biomarker of whole body oxidative stress. Free Radic. Res., 37, 12091213.
  • ZHAO, H., JOSEPH, J., ZHANG, H., KAROUI, H. & KALYANARAMAN, B. (2001a). Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free Radic. Biol. Med., 31, 599606.
  • ZHAO, H., KALIVENDI, S., ZHANG, H., JOSEPH, J., NITHIPATIKOM, K., VASQUEZ-VIVAR, J. & KALYANARAMAN, B. (2003). Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic. Biol. Med., 34, 13591368.
  • ZHAO, K., WHITEMAN, M., SPENCER, J.P. & HALLIWELL, B. (2001b). DNA damage by nitrite and peroxynitrite: protection by dietary phenols. Methods Enzymol., 335, 296307.