Plant cannabinoids: a neglected pharmacological treasure trove

Authors

  • Raphael Mechoulam

    Corresponding author
    1. Department of Medicinal Chemistry and Natural Products, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
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Department of Medicinal Chemistry and Natural Products, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel. E-mail: mechou@cc.huji.ac.il

Abstract

Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, Δ9-tetrahydrocannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest.

British Journal of Pharmacology (2005) 146, 913–915. doi:10.1038/sj.bjp.0706415

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