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Preparation and characterization of a new bioinorganic composite: collagen and hydroxyapatite
Article first published online: 23 DEC 2010
2000 International Union of Biochemistry and Molecular Biology
Biotechnology and Applied Biochemistry
Volume 32, Issue 3, pages 155–159, December 2000
How to Cite
Mythili, J., Sastry, T. P. and Subramanian, M. (2000), Preparation and characterization of a new bioinorganic composite: collagen and hydroxyapatite. Biotechnology and Applied Biochemistry, 32: 155–159. doi: 10.1042/BA20000055
- Issue published online: 23 DEC 2010
- Article first published online: 23 DEC 2010
- Received 24 July 2000/17 August 2000; accepted 17 August 2000
- crystal growth;
- dicalcium phosphate;
Studies on biomineralization in bone have opened new arenas in the field of fabrication and engineering of bone-graft devices. A new bioinorganic composite was prepared by introducing processed collagenous matrices into the calcifying solutions at pH 7.8–8.0. The calcifying solutions were prepared by using a saturated dicalcium salt solution. Hydroxyapatite grew on the matrix over a period of 3–5 days in a specially designed crystallizing chamber. Changes in biochemical characters and biophysical parameters have given interesting insights into factors affecting and effecting initiation and progression of calcification on organic matrices.