Bioreactor systems for the production of biopharmaceuticals from animal cells


  • James N. Warnock,

    1. Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS 39762, U.S.A.
    Search for more papers by this author
  • Mohamed Al-Rubeai

    Corresponding author
    1. School of Chemical and Bioprocess Engineering, University College Dublin and Center for Synthesis and Chemical Biology, Belfield, Dublin 4, Ireland
    Search for more papers by this author

To whom correspondence should be addressed (email


The demand for biopharmaceutical products is set to see a significant increase over the next few years. As a consequence, the processes used to produce these products must be able to meet market requirements. The present paper reviews the current technologies available for animal cell culture and highlights the advantages and disadvantages of each method, while also providing details of recent case studies. Processes are described for both suspension and anchorage-dependent cell lines.