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Microbial quorum sensing: a tool or a target for antimicrobial therapy?

Authors

  • Sheetal Raina,

    1. Cell Communication Research Group, Department of Molecular and Applied Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, U.K.
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  • Daniela De Vizio,

    1. Cell Communication Research Group, Department of Molecular and Applied Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, U.K.
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  • Mark Odell,

    1. Cell Communication Research Group, Department of Molecular and Applied Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, U.K.
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  • Mark Clements,

    1. Cell Communication Research Group, Department of Molecular and Applied Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, U.K.
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  • Sophie Vanhulle,

    1. Unité de Microbiologie (MBLA), Université Catholique de Louvain, Croix du Sud 3/6, 1348 Louvain-la-Neuve, Belgium
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  • Tajalli Keshavarz

    Corresponding author
    1. Cell Communication Research Group, Department of Molecular and Applied Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, U.K.
      To whom correspondence should be addressed (email t.keshavarz@wmin.ac.uk).
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To whom correspondence should be addressed (email t.keshavarz@wmin.ac.uk).

Abstract

Inter-cell communication aided by released chemical signals when cell density reaches a critical concentration has been investigated for over 30 years as quorum sensing. Originally discovered in Gram-negative bacteria, quorum-sensing systems have also been studied extensively in Gram-positive bacteria and dimorphic fungi. Microbial communities communicating via quorum sensing employ various chemical signals to supervise their surrounding environment, alter genetic expression and gain advantage over their competitors. These signals vary from acylhomoserine lactones to small modified or unmodified peptides to complex γ-butyrolactone molecules. The scope of this review is to give an insight into some of the quorum-sensing systems now known and to explore their role in microbial physiology and development of pathogenesis. Particular attention will be dedicated to the signalling molecules involved in quorum-sensing-mediated processes and the potential shown by some of their natural and synthetic analogues in the treatment of infections triggered by quorum sensing.

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