Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing
Article first published online: 9 JAN 2012
2005 Société Française des Microscopies and Société Biologie Cellulaire de France
Biology of the Cell
Volume 97, Issue 3, pages 173–183, March 2005
How to Cite
Morasso, M. I. and Tomic-Canic, M. (2005), Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing. Biology of the Cell, 97: 173–183. doi: 10.1042/BC20040098
- Issue published online: 9 JAN 2012
- Article first published online: 9 JAN 2012
- Received 9 August 2004, Accepted 6 October 2004
- C.R.A. Modulation of wound repair by members of the fibroblast growth factor family In the molecular and cellular biology of wound repair 1996 New York Plenum Press 195–248.
- Stem cells in the skin: waste not, Wnt not Genes Dev. 2003 17 1189–2000.
- c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Curr. Biol.. 2001 11 558–568.
- Participation of bone marrow-derived cells in cutaneous wound healing J. Cell. Physiol. 2003 196 245–250.
- Unique keratinocyte-specific effects of interferon-γ that protect skin from viruses identified using transcriptional profiling Antiviral Ther. 2003 8 541–554.
- Three clonal types of keratinocyte with different capacities for multiplication Proc. Natl. Acad. Sci. U.S.A. 1987 84 2302–2306.
- Human skin-derived stem cells migrate throughout forebrain and differentiate into astrocytes after injection into adult mouse brain Neurosci. Res.. 2004 77 475–486.
- Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche Cell (Cambridge, Mass.) 2004 118 635–648.
- Structure and function of hemidesmosomes: more than simple adhesion complexes J. Invest. Dermatol. 1999 112 411–418.
- Clinical efficacy and mechanism of bilayered living human skin equivalent (HSE) in treatment of diabetic foot ulcers Surg. Tech. Int.. 2003 11 23–31.
- Controlling skin morphogenesis: hope and despair Curr. Opin. Biotechnol. 2003 14 520–525.
- Distinctive integrin expression in the newly forming epidermis during wound healing in humans J. Invest. Dermatol. 1993 101 600–604.
- Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome Cell (Cambridge, Mass.) 1999 99 143–153. , et al.,
- Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia Biochem. Biophys. Res. Commun. 1997 236 231–238.
- Reconstituted skin from murine embryonic stem cells Curr. Biol.. 2003 13 849–853.
- Label-retaining cells reside in the bulge area of the pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis Cell (Cambridge, Mass.) 1990 61 1329–1337.
- Epithelial stem class in the skin: definition, markers, localization and functions Exp. Dermatol. 1999 8 80–88.
- α3β1 and α6β4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development J. Cell Sci. 2000 113 3051–3062.
- S100 proteins in the epidermis J. Invest. Dermatol. 2004 123 23–33.
- Understanding experimental biology of skin equivalent: from laboratory to clinical use in patients with burns and chronic wounds Am. J. Surg.. 2004 187 29S–33S.
- Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development 2003 130 2793–2808.
- Getting under the skin of epidermal morphogenesis Nat. Rev. Genet. 2002 3 199–209.
- Socializing with the neighbors: stem cells and their niche Cell (Cambridge, Mass.) 2004 116 769–778.
- The major pathways of keratinocyte differentiation as defined by keratin expression: an overview Adv. Dermatol. 1989 4 277–299.
- The multifaceted adult epidermal stem cell Curr. Opin. Cell Biol. 2003 15 771–777.
- c-Myc promotes differentiation of human epidermal stem cells Genes Dev. 1997 11 2869–2882.
- Multiple classes of stem cells in cutaneous epithelium; a lineage analysis of adult mouse skin EMBO J. 2001 20 1215–1222.
- The α3 laminin subunit, α6β4 and α3β1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin J. Cell Sci. 1999 112 2615–2629.
- Keratinocytes in human wounds express αv β6 integrin J. Invest. Dermatol. 1996 106 42–48.
- The secret life of the hair follicle Trends Genet. 1992 8 55–61.
- c-Myc and epidermal stem cell fate determination J. Dermatol. 2004 31 368–375.
- B-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin Cell (Cambridge, Mass.) 2001 105 533–545.
- Intercellular adhesion, signalling and the cytoskeleton Nature Cell Biol. 2002 4 101–108.
- Links between signal transduction, transcription and adhesion in epithelial bud development Nature (London) 2003 422 317–322.
- Epidermal growth factor and transforming growth factor α specifically induce the activation- and hyperproliferation-associated keratins 6 and 16 Proc. Natl. Acad. Sci. U.S.A. 1993 90 6786–6790.
- Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells Lancet 2004 364 172–178.
- Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression Cell (Cambridge, Mass.) 1993 73 713–724.
- Stem-cell patterning and fate in human epidermis Cell (Cambridge, Mass.) 1995 80 83–93.
- Epithelial barrier function: assembly and structural features of the cornified cell envelope Bioessays 2002 24 789–800.
- δNp63α functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes Oncogene 2003 22 3635–3644.
- Inflammatory versus proliferative processes in epidermis Tumor necrosis factor α induces K6b keratin synthesis through a transcriptional complex containing NFκB and C/EBPβ J. Biol. Chem. 2000 275 32077–32088.
- Interleukin-1 induces transcription of keratin K6 in human epidermal keratinocytes J. Invest. Dermatol. 2001 116 330–338.
- Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation J. Invest. Dermatol. Symp. Proc.. 2002 7 41–45.
- p63 is the molecular switch for initiation of an epithelial stratification program Genes and Dev. 2004 18 126–131.
- β1 Integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms Mol. Biol. Cell. 2000 11 453–466.
- Krstic-Dermonacos M. Demonacos C. Tissue specificity of steroid action: Glucocorticoids in epidermis Molecular Mechanisms of action of steroid hormone receptors 2002 Research Signpost Co. 1–25.
- Identification and isolation of candidate human keratinocyte stem-cells based on cell-surface phenotype Proc. Natl. Acad. Sci. U.S.A. 1998 95 3902–3907.
- Extensive tissue-regenerative capacity of neonatal human keratinocyte stem cells and their progeny J. Clin. Invest. 2004 113 390–400.
- Rays and arrays: the transcriptional program in the response of human epidermal keratinocytes to UVB illumination FASEB J. 2001 15 2533–2535.
- Somatic epidermal stem cells can produce multiple cell lineages during development Stem Cells 2002 20 21–31.
- Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge J. Invest. Dermatol. 2003 121 963–968.
- Barrier function of the skin: ‘La raison d'etre’ of the epidermis J. Invest. Dermatol. 2003 121 231–241.
- The intracellular functions of α6β4 integrin are regulated by EGF J. Cell Biol. 1996 134 241–253.
- Wound healing-aiming for perfect skin regeneration Science (Washington, D.C.) 1997 276 75–81.
- Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin Genes Dev. 2001 15 1688–1705.
- Identification and characterization of a novel component of the cornified envelope, cornifelin Biochem. Biophys. Res. Commun. 2004 318 803–813.
- Molecular mechanisms regulating hair follicle development J. Invest. Dermatol. 2002 118 216–225.
- p63 is a p53 homologue required for limb and epidermal morphogenesis Nature (London) 1999 398 708–713.
- Identification of a conserved cluster of skin-specific genes encoding secreted proteins Gene 2004 334 123–131.
- Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen J. Invest. Dermatol. 1999 112 470–475.
- Capturing and profiling adult hair follicle stem cells Nature Biotechnol. 2004 22 411–417.
- The effects of cyclooxygenase isozyme inhibition on incisional wound healing in mouse skin J. Invest. Dermatol. 2002 119 1189–1195.
- Becaplermin: recombinant platelet-derived growth factor, a new treatment for healing diabetic foot ulcers Exp. Opin. Biol. Ther.. 2002 2 211–218.
- C.R.A. Epidermal growth factor and transforming growth factor α The molecular and cellular biology of wound repair 1996 New York Plenum Press 171–194.
- Differential expression of p63 isoforms in normal tissues and neoplastic cells J. Pathol. 2002 198 417–427.
- Morphogenesis and renewal of hair follicles from adult multipotent stem cells Cell (Cambridge, Mass.) 2001 104 233–245.
- Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor J. Biol. Chem.. 2002 277 45195–45202.
- The biology of hair follicles N. Engl. J. Med.. 1999 341 491–497.
- p63 identifies keratinocyte stem cells Proc. Natl. Acad. Sci. U.S.A. 2001 98 3156–3161.
- Epithelial structural proteins of the skin and oral cavity: function in health and disease Crit. Rev. Oral Biol. Med.. 2000 11 383–408.
- Regulated expression of human filaggrin in keratinocytes results in cytoskeletal disruption, loss of cell—cell adhesion, and cell cycle arrest Exp. Cell Res. 2001 270 199–213.
- Conditional ablation of β1 integrin in the skin: severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination J. Cell Biol. 2000 150 1149–1169.
- Hair follicle differentiation and regulation Int. J. Dev. Biol.. 2004 48 163–170.
- Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays Proc. Natl. Acad. Sci. U.S.A. 2002 99 2965–2970.
- Apligraf living skin equivalent for healing venous and chronic wounds J. Cutan. Med. Surg.. 1998 3 24–28.
- Cutaneous wound healing N. Engl. J. Med.. 1999 341 738–746.
- Involvement of follicular stem cells in forming not only the follicle but also the epidermis Cell (Cambridge, Mass.) 2000 102 451–461.
- Epidermal signal transduction and transcription factor activation in activated keratinocytes J. Dermatol. Sci.. 1998 17 167–181.
- Rovee D. Maibach H. Epidermal repair and the chronic wound The epidermis in wound healing 2004 U.S.A. CRC Press 25–57.
- Defining the epithelial stem cell niche in skin Science (Washington, D.C.) 2004 303 359–363.
- Revisiting the bulge Dev. Cell. 2004 6 454–456.
- p63 Gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation Am. J. Hum. Genet. 2001 69 481–492. , et al.,
- Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21 Genomics 1993 18 92–99.
- Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis Oncogene 1999 18 4870–4878.
- Deregulated expression of c-Myc depletes epidermal stem cells Nat. Genet. 2001 28 165–168.
- Stem cell fate and patterning in mammalian epidermis Curr. Opin. Genet. Dev.. 2001 11 410–417.
- The function of KGF in morphogenesis of epithelium and reepithelialization of wounds Science (Washington, D.C.) 1994 266 819–822.
- Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair J. Cell Biol. 2003 163 327–337.
- p63, a p53 homolog at 3q27–3q29, encodes multiple products with transactivating, death-inducing and dominant-negative activities Mol. Cell. 1998 2 305–316.
- p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development Nature (London) 1999 398 714–718.
- On the shoulders of giants: p63, p73 and the rise of p53 Trends Genet. 2002 18 90–95.
- Transforming growth factor-β1 modulates β1 and β5 integrin receptors and induces the de novo expression of the αvβ6 heterodimer in normal human keratinocytes: implications for wound healing J. Cell Biol. 1995 129 853–865.