These authors contributed equally to this work.
The ciliary pocket: a once-forgotten membrane domain at the base of cilia
Article first published online: 3 JAN 2012
2011 Société Française des Microscopies and Société Biologie Cellulaire de France
Biology of the Cell
Volume 103, Issue 3, pages 131–144, March 2011
How to Cite
Ghossoub, R., Molla-Herman, A., Bastin, P. and Benmerah, A. (2011), The ciliary pocket: a once-forgotten membrane domain at the base of cilia. Biology of the Cell, 103: 131–144. doi: 10.1042/BC20100128
- Issue published online: 3 JAN 2012
- Article first published online: 3 JAN 2012
- Received 10 December 2010; Accepted 23 December 2010
- Flagellum elongation is required for correct structure, orientation and function of the flagellar pocket in Trypanosoma brucei J. Cell Sci.. 2008 121 3704–3716.
- Phagokinetic tracks of 3T3 cells: parallels between the orientation of track segments and of cellular structures which contain actin or tubulin Cell 1977 12 333–339.
- Clathrin-mediated endocytosis is essential in Trypanosoma brucei EMBO J. 2003 22 4991–5002.
- The morphogenesis of basal bodies and accessory structures of the cortex of the ciliated protozoan Tetrahymena pyriformis J. Cell Biol.. 1969 40 716–733.
- Endosomal system of Paramecium: coated pits to early endosomes J. Cell Sci.. 1992 101 449–461.
- Intraflagellar transport: it's not just for cilia anymore Curr. Opin. Cell Biol.. 2010 22 75–80.
- Ciliated secretory cells in the pars distalis of the mouse hypophysis J. Ultrastruct. Res.. 1961 5 453–467.
- Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella J. Cell Sci.. 2007 120 478–491.
- Cilia – the masterplan J. Cell Sci.. 2008 121 5–6.
- Actin in sperm tails and meiotic spindles Nature 1971 234 408–410.
- The primary cilium as a complex signaling center Curr. Biol.. 2009 19 R526–R535.
- MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling Dev. Cell 2010 19 270–283.
- Biogenesis of the trypanosome endo-exocytotic organelle is cytoskeleton mediated PLoS Biol.. 2008 6 e105.
- The fine structure of ependyma in the brain of the rat J. Cell Biol.. 1963 19 415–439.
- An electron microscope study of spermatid differentiation in the toad, Bufo arenarum Hensel J. Biophys. Biochem. Cytol. 1956 2 223–240.
- Septins and the lateral compartmentalization of eukaryotic membranes Dev. Cell 2009 16 493–506.
- Actin in the photoreceptor connecting cilium: immunocytochemical localization to the site of outer segment disk formation J. Cell Biol.. 1984 99 239–247.
- Primary cilia organization reflects polarity in the growth plate and implies loss of polarity and mosaicism in osteochondroma Lab. Invest. 2010 90 1091–1101.
- Submicroscopic organization of retinal cones of the rabbit J. Biophys. Biochem. Cytol. 1958 4 743–746.
- Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP Nat. Cell Biol.. 2010 12 703–710.
- Primary cilia are highly oriented with respect to collagen direction and long axis of extensor tendon J. Orthop. Res.. 2010 28 77–82.
- Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia Am. J. Hum. Genet. 2009 85 890–896. et al.
- Elucidation of clathrin-mediated endocytosis in Tetrahymena reveals an evolutionarily convergent recruitment of dynamin PLoS Genet. 2005 1 e52.
- Morphogenetic factors influencing the shape of the sperm head Dev. Biol.. 1971 26 220–251.
- The Spermatozoon: Maturation, Motility, Surface Properties, and Comparative Aspects 1979 Woods Hole, MA Urban and Schwarzenberg, Baltimore, Boston, and the Swope Conference Center of the Marine Biological Laboratories.
- Observations on the cytoplasmic membranes of testicular cells, examined by phase contrast and electron microscopy J. Biophys. Biochem. Cytol. 1958 4 135–142.
- The trypanosome flagellar pocket Nat. Rev. Microbiol. 2009 7 775–786.
- Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse Nat. Cell Biol.. 2009 11 1332–1339.
- Planar cell polarity and cilia Semin. Cell Dev. Biol.. 2009 20 998–1005.
- The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly Mol. Biol. Cell 2006 17 3781–3792.
- The relationship of cilia with cell division and differentiation J. Cell Biol.. 1971 49 226–229.
- Membrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes Proc. Natl. Acad. Sci. U.S.A. 2009 106 17425–17430.
- Morphogenesis of rod cells in the retina of the albino rat: a scanning electron microscopic study Anat. Rec.. 1979 195 707–717.
- A differential role for actin during the life cycle of Trypanosoma brucei EMBO J. 2004 23 780–789.
- The ciliary necklace. A ciliary membrane specialization J. Cell Biol.. 1972 53 494–509.
- Ciliogenesis in photoreceptor cells of the retina Exp. Eye Res.. 1981 33 433–446.
- The immunological synapse: a focal point for endocytosis and exocytosis J. Cell Biol.. 2010 189 399–406.
- Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function PLoS Genet. 2005 1 e53.
- A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution Science 2010 329 436–439.
- Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa Dev. Cell 2005 8 343–352. et al.
- The sensory cilia of Caenorhabditis elegans WormBook 2007 8 1–22.
- Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors Dev. Dyn.. 2008 237 1982–1992.
- AP-1 clathrin adaptor facilitates cilium formation and functions with RAB-8 in C. elegans ciliary membrane transport J. Cell Sci.. 2010 123 3966–3977. et al.
- Functional genomic screen for modulators of ciliogenesis and cilium length Nature 2010 464 1048–1051.
- The Sept4 septin locus is required for sperm terminal differentiation in mice Dev. Cell 2005 8 353–364.
- Molecular architecture of the trypanosome cytoskeleton Mol. Biochem. Parasitol. 1998 93 1–9.
- Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes EMBO J. 2003 22 5336–5346.
- A motility in the eukaryotic flagellum unrelated to flagellar beating Proc. Natl. Acad. Sci. U.S.A. 1993 90 5519–5523.
- Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei J. Cell Sci.. 2010 123 2884–2891.
- The primary cilium as a cellular signaling center: lessons from disease Curr. Opin. Genet. Dev.. 2009 19 220–229.
- The flagellum and flagellar pocket of trypanosomatids Mol. Biochem. Parasitol. 2001 115 1–17.
- Protein uptake and digestion in bloodstream and culture forms of Trypanosoma brucei J. Protozool. 1975 22 40–53.
- Actin in membrane trafficking Curr. Opin. Cell Biol.. 2007 19 453–458.
- Cilia in different segments of the rat nephron J. Biophys. Biochem. Cytol. 1961 11 248–252.
- Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells Proc. Natl. Acad. Sci. U.S.A. 2007 104 4413–4418.
- A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells Hum. Mol. Genet. 2008 17 71–86. et al.
- The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia J. Cell Sci.. 2010 123 1785–1795. et al.
- A light and electron microscopic study of cellular differentiation in the pancreatic islets of the mouse Am. J. Anat.. 1958 103 275–311.
- Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? Annu. Rev. Cell Dev. Biol.. 2010 26 59–87.
- Coated pits with pinocytosis in Tetrahymena J. Cell Sci.. 1983 63 209–222.
- Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells Nat. Genet. 2008 40 871–879.
- Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella J. Cell Biol.. 2000 151 709–718.
- Intraflagellar transport and cilia-dependent diseases Trends Cell Biol.. 2002 12 551–555.
- Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling Curr. Top. Dev. Biol.. 2008 85 23–61.
- Mutant sensory cilia in the nematode Caenorhabditis elegans Dev. Biol.. 1986 117 456–487.
- Fine structure of a periciliary ridge complex of frog retinal rod cells revealed by ultrahigh resolution scanning electron microscopy J. Cell Biol.. 1983 96 265–276.
- Insect sperm: their structure and morphogenesis J. Cell Biol.. 1970 44 243–277.
- Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells J. Cell Biol.. 2010 191 303–312.
- Analysis of the morphology and function of primary cilia in connective tissues: a cellular cybernetic probe? Cell Motil. 1985 5 175–193.
- Confocal analysis of primary cilia structure and colocalization with the Golgi apparatus in chondrocytes and aortic smooth muscle cells Cell Biol. Int.. 1997 21 483–494.
- Primary cilia in fibroblast-like type B synoviocytes lie within a cilium pit: a site of endocytosis Histol. Histopathol. 2010 25 865–875.
- The development of basal bodies and flagella in Allomyces arbusculus J. Cell Biol.. 1964 23 339–354.
- The ciliary membrane Curr. Opin. Cell Biol.. 2010 22 541–546.
- The sensory cilium of retinal rods is analogous to the transitional zone of motile cilia Cell Tissue Res.. 1975 161 421–430.
- Update on Usher syndrome Curr. Opin. Neurol. 2009 22 19–27.
- Organization and functions of cytoskeleton in metazoan ciliated cells Biol. Cell 1988 63 183–193.
- Immunocytochemical localization of tubulin, actin, and myosin in axonemes of ciliated cells from quail oviduct Proc. Natl. Acad. Sci. U.S.A. 1982 79 3198–3202.
- Overview of structure and function of mammalian cilia Annu. Rev. Physiol. 2007 69 377–400.
- Intraflagellar transport molecules in ciliary and nonciliary cells of the retina J. Cell Biol.. 2010 189 171–186.
- Endocytosis in spermatids during spermiogenesis of the mouse Biol. Cell 1989 67 289–298.
- Endocytic origin for periaxonemal vesicles along the flagellum during mouse spermiogenesis Gamete Res.. 1988 21 451–463.
- Visualization of detyrosination along single microtubules reveals novel mechanisms of assembly during cytoskeletal duplication in trypanosomes Cell 1989 57 211–221.
- Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells J. Cell Biol.. 1962 15 363–377.
- Reconstructions of centriole formation and ciliogenesis in mammalian lungs J. Cell Sci.. 1968 3 207–230.
- Electron microscope study on the development of ciliary components of the neural epithelium of the chick embryo Z. Zellforsch. Mikrosk. Anat.. 1958 49 1–12.
- Centrosome polarization delivers secretory granules to the immunological synapse Nature 2006 443 462–465.
- Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1 Cell 1999 97 877–887.
- The fine structure of the retina studied with the electron microscope. IV. Morphogenesis of outer segments of retinal rods J. Biophys. Biochem. Cytol. 1959 6 225–230.
- 1001 model organisms to study cilia and flagella Biol. Cell 2011 103 109–130.
- Dishevelled links basal body docking and orientation in ciliated epithelial cells Trends Cell Biol.. 2008 18 517–520.
- Periciliary structure of developing rat photoreceptor cells. A deep etch replica and freeze substitution study J. Electron. Microsc. 1999 48 929–935 (Tokyo).
- Dynamin- and clathrin-dependent endocytic pathway in unicellular eukaryote Paramecium Biochem. Cell Biol.. 2004 82 547–558.
- Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss PLoS Genet. 2010 6 e1000955.
- Functional dissection of Rab GTPases involved in primary cilium formation J. Cell Biol.. 2007 178 363–369.