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Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor alpha

Authors

  • Zhenhua Ren,

    1. Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, Peoples Republic of China
    2. Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, Peoples Republic of China
    3. Department of Anatomy, Anhui Medical University, Hefei 230032, Peoples Republic of China
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  • Chunlin Zou,

    1. Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, Peoples Republic of China
    2. Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, Peoples Republic of China
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  • Huijun Ji,

    1. Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, Peoples Republic of China
    2. Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, Peoples Republic of China
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  • Y Alex Zhang

    Corresponding author
    1. Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, Peoples Republic of China
    2. Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, Peoples Republic of China
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email yaz@bjsap.org

Abstract

E2 (oestradiol-17β) is an important hormone that regulates various cell functions including insulin production. hIPCs (human islet-derived precursor cells) are capable of proliferating and differentiating into cells that secrete insulin in response to glucose in vivo and in vitro. However, the effect of E2 on hIPCs is currently unclear. In this study, we found that ERα (oestrogen receptor alpha), but not ERβ, was expressed on hIPCs, and E2 promoted the proliferation and inhibited the differentiation of adult hIPCs. Although fetal hIPCs also express ERα, no effect of E2 on the fetal hIPCs was observed, suggesting differing roles of E2 at different stages of pancreatic development. This study indicates that E2 may be one of the key factors that control the turnover of adult pancreatic β cells by regulating the proliferation and differentiation of adult hIPCs through ERα.

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