Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesophageal squamous carcinoma cell line Eca109 cells

Authors

  • Yadong Feng,

    1. Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Peoples Republic of China
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  • Hong Zhu,

    1. Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Peoples Republic of China
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  • Tingsheng Ling,

    1. Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Peoples Republic of China
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  • Bo Hao,

    1. Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Peoples Republic of China
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  • Guoxin Zhang,

    1. Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Peoples Republic of China
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  • Ruihua Shi

    Corresponding author
    1. Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Peoples Republic of China
      To whom correspondence should be addressed (email ruihuashi@126.com).
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To whom correspondence should be addressed (email ruihuashi@126.com).

Abstract

HIF-1α (hypoxia-inducible factor 1 alpha) is believed to promote oesophageal squamous tumour growth. Thus, an HIF-1α inhibitor is viewed as a therapeutic target in treating oesophageal cancer. Recently, YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole] has been widely used as a potential HIF-1α inhibitor and is being developed as a novel anticancer drug. However, little is known about the effects of YC-1 in human oesophageal cancer. In the present study, we aimed to investigate these effects in an esophageal squamous cancer cell line; i.e. Eca109 cells. We found that YC-1 abolished the hypoxia-induced up-regulation of HIF-1α. YC-1 arrested cell growth and inhibited cell migration activities in Eca109 cells. These results suggest that YC-1 may be a chemotherapy candidate against oesophageal squamous cancers.

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