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Correlation between the interaction of the vinculin tail domain with lipid membranes, its phosphorylation and cell mechanical behaviour


  • Wolfgang H. Goldmann

    Corresponding author
    1. Center for Medical Physics and Technology, Biophysics Group, FriedrichAlexanderUniversity of ErlangenNuremberg, Henkestrasse 91, 91052 Erlangen, Germany
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Cell adhesion and cell–cell contacts are a pre-requisite for proper metabolism, protein synthesis and cell survival. Integrins are the transmembrane receptors that link the extracellular matrix via the FAC (focal adhesion complex) with the cytoskeleton. Vinculin is a pivotal FAC protein that has not only been implicated in regulating FAC formation and transmitting mechanical forces, but also in associating with membranous lipids in biological systems.