Get access

Role of ZNRD1 (zinc ribbon domain-containing 1) in angiogenesis of leukaemia cells

Authors

  • Liu Hong,

    Corresponding author
    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Yu Han,

    Corresponding author
    1. Otorhinolaryngological Department, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Shujun Li,

    Corresponding author
    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Jianjun Yang,

    Corresponding author
    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Taiqian Gong,

    Corresponding author
    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Jipeng Li,

    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Jianyong Zheng,

    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Hongwei Zhang,

    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Qingchuan Zhao,

    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Kaichun Wu,

    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author
  • Daiming Fan

    Corresponding author
    1. State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Search for more papers by this author

Liu Hong, Yu Han, Shujun Li, Jianjun Yang and Taiqian Gong and contributed equally to this work.

To whom correspondence should be addressed (email hlhyhj@126.com or hongliu1@fmmu.edu.cn).

Abstract

Here, we have first investigated the roles of ZNRD1 in angiogenesis of leukaemia. The leukaemia cell line K562 was transfected with the vector that included the full-length cDNA of ZNRD1, then the growth and angiogenesis of cells were detected. Up-regulation of ZNRD1 could significantly inhibit the growth of cells, reduce tumour microvessel densities and inhibit the VEGF (vascular endothelial growth factor) production. The results of human miRNA array and real-time PCR showed that ZNRD1 could significantly up-regulate the expression of miR-214 and down-regulate the expression of miR-296. Taken together, ZNRD1 might inhibit tumour angiogenesis and could be considered as a target for leukaemia therapy.

Ancillary