Discrepant effects of mammalian factors on molluscan cell motility, chemotaxis and phagocytosis: Divergent evolution or finely tuned contingency?
Article first published online: 2 JAN 2013
2010 International Federation for Cell Biology
Cell Biology International
Volume 34, Issue 11, pages 1091–1094, November 2010
How to Cite
Malagoli, D. and Ottaviani, E. (2010), Discrepant effects of mammalian factors on molluscan cell motility, chemotaxis and phagocytosis: Divergent evolution or finely tuned contingency?. Cell Biology International, 34: 1091–1094. doi: 10.1042/CBI20100514
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Received 12 July 2010; accepted 26 July 2010
- cell migration;
- innate immunity;
Cell motility, cell migration and phagocytosis are distinct, though frequently sequential, processes. They are fundamental for the maintenance of homoeostasis in single cells as well as in pluricellular organisms. Like vertebrates, invertebrate immune functions are strictly dependent on cell motility, chemotaxis and phagocytosis. Several comparative immunobiology experiments have tested the effects of mammalian factors on cell migration and phagocytic activity in invertebrate immune-competent cells. The discrepancies that were found suggest various hypotheses, e.g. species-specific reactions to heterologous factors. Here, we reconsider data concerning the effects of POMC (proopiomelanocortin)-derived peptides, cytokines and growth factors on molluscan immunocytes in the light of recent findings that also encompass the effects of experimental conditions.