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MicroRNAs and cystic fibrosis – an epigenetic perspective

Authors

  • Wenming Xu,

    1. SCUCUHK Joint Laboratory for Reproductive Medicine, Institute of Women and Childrens Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Peoples Republic of China
    2. Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
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  • Chen Hui,

    1. Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
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  • Sidney Siu Bun Yu,

    1. Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
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  • Chen Jing,

    1. Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
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  • Hsiao Chang Chan

    Corresponding author
    1. SCUCUHK Joint Laboratory for Reproductive Medicine, Institute of Women and Childrens Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Peoples Republic of China
    2. Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
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To whom correspondence should be addressed (email hsiaocchan@cuhk.edu.hk).

Abstract

CF (cystic fibrosis) is a recessive genetic disease caused by mutations of the CFTR (cystic fibrosis transmembrane conductance regulator), a cAMP-activated anion channel, exhibiting a multitude of clinical manifestations including lung inflammation/infection, pancreatic insufficiency/diabetes, intestinal obstruction and infertility in both sexes. While mutation DF508 is found in 70% of CF patients, large variation in disease phenotypes and severity is observed among the patients. This review discusses current theories accounting for the disease variations and puts forth an epigenetic hypothesis involving microRNAs.

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