Role of bone marrow-derived mesenchymal stem cells in the prevention of hyperoxia-induced lung injury in newborn mice

Authors

  • Xiaoying Zhang,

    Corresponding author
    1. Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author
  • Hui Wang,

    Corresponding author
    1. Department of Science Division, The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author
  • Yun Shi,

    1. Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author
  • Wei Peng,

    1. Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author
  • Sheng Zhang,

    1. Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author
  • Wanqiao Zhang,

    1. Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author
  • Jing Xu,

    1. Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author
  • Yabo Mei,

    1. Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author
  • Zhichun Feng

    Corresponding author
    1. Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China
    Search for more papers by this author

These authors have contributed equally to this work.

Correspondence may be addressed to either of the authors (email fengzhichun81@sina.com or xiaoyingzhang79@163.com).

Abstract

BPD (bronchopulmonary dysplasia) is predominantly characterized by persistent abnormalities in lung structure and arrested lung development, but therapy can be palliative. While promising, the use of BMSC (bone marrow-derived mesenchymal stem cell) in the treatment of lung diseases remains controversial. We have assessed the therapeutic effects of BMSC in vitro and in vivo. In vitro co-culturing with injured lung tissue increased the migration-potential of BMSC; and SP-C (surfactant protein-C), a specific marker of AEC2 (type II alveolar epithelial cells), was expressed. Following intraperitoneal injection of BMSC into experimental BPD mice on post-natal day 7, it was found that BMSC can home to the injured lung, express SP-C, improve pulmonary architecture, attenuate pulmonary fibrosis and increase the survival rate of BPD mice. This work supports the notion that BMSC are of therapeutic benefit through the production of soluble factors at bioactive levels that regulate the pathogenesis of inflammation and fibrosis following hyperoxia.

Ancillary