Get access

Protection of cells from nitric oxide-mediated apoptotic death by glutathione C60 derivative

Authors

  • Zhen Hu,

    1. School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China
    Search for more papers by this author
  • Chunhua Zhang,

    Corresponding author
    1. School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China
      Correspondence may be addressed to either of these authors (email yudong.huang@yahoo.com.cn or zhangchunhua@hit.edu.cn).
    Search for more papers by this author
  • Peiyi Tang,

    1. School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China
    Search for more papers by this author
  • Cuiyun Li,

    1. School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China
    Search for more papers by this author
  • Yuhuan Yao,

    1. School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China
    Search for more papers by this author
  • Shaofan Sun,

    1. School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China
    Search for more papers by this author
  • Li Zhang,

    1. School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China
    Search for more papers by this author
  • Yudong Huang

    Corresponding author
    1. School of Chemical Engineering and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, Peoples Republic of China
      Correspondence may be addressed to either of these authors (email yudong.huang@yahoo.com.cn or zhangchunhua@hit.edu.cn).
    Search for more papers by this author

Correspondence may be addressed to either of these authors (email yudong.huang@yahoo.com.cn or zhangchunhua@hit.edu.cn).

Abstract

The influence of the glutathione C60 derivative on the cytotoxicity of a highly reactive free radical NO (nitric oxide) has been investigated. Consistent with its cytoprotective abilities, the derivative scavenges ROS (reactive oxygen species) and RNS (reactive nitrogen species) both in vitro and under cell-free conditions. Moreover, the glutathione C60 derivative protected PC12 cells from the cytotoxic effect of the NO-releasing compound, SNP (sodium nitroprusside). Addition of glutathione C60 derivative alone did not induce apoptosis and necrosis. The results suggest that the glutathione C60 derivative has the potential to prevent NO-mediated cell death without evident toxicity.

Get access to the full text of this article

Ancillary