Esophageal telocytes and hybrid morphologies

Authors

  • Mugurel Constantin Rusu,

    Corresponding author
    1. Discipline of Anatomy, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
      (email anatomon@gmail.com)
    Search for more papers by this author
  • Mihnea Ioan Nicolescu,

    1. Molecular Medicine Department, “Victor Babeş” National Institute of Pathology, Bucharest, Romania and Cellular and Molecular Medicine Division, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Search for more papers by this author
  • Adelina Maria Jianu,

    1. Department of Anatomy, Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, Timioara, Romania
    Search for more papers by this author
  • Rodica Lighezan,

    1. Department of Histology, Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, Timioara, Romania
    Search for more papers by this author
  • Vasile Sorin Mănoiu,

    1. Department of Cellular and Molecular Biology, National Institute of Research and Development for Biological Sciences, Bucharest, Romania
    Search for more papers by this author
  • Dumitru Păduraru

    1. Department of Anatomy, “Gr.T.Popa” University of Medicine and Pharmacy, Iaşi, Romania
    Search for more papers by this author

(email anatomon@gmail.com)

Abstract

TCs (telocytes) are actually defined as stromal cells with specific long and thin prolongations, called Tp (telopodes). They have been positively identified in various tissues and we now report their presence in the esophagus. These cells were identified by TEM (transmission electron microscopy) in esophageal samples of Wistar rats (n = 5) occurring beneath the basal epithelial layer, in submucosa, closely related to smooth and striated muscular fibres, as also in the adventitia. They are closely related to mast cells, macrophages and microvessels. Hybrid morphologies of stromal cells processes were found: cytoplasmic processes continued distally in a telopodial fashion. Telopodes alone may not be sufficient, however, for a safe diagnosis of TCs in TEM. A larger set of specific standards (such as the telopodial emergence, and the size of the cell body and telopodes) should be considered to differentiate TCs from various species of fibroblasts. The morphological and ultrastructural features should distinguish between TCs and interstitial cells of Cajal in the digestive tract.

Ancillary