Increased plasma concentrations of vasopressin, oxytocin, cortisol and the prostaglandin F2α metabolite during labour in the dog

Authors


Professor K. Olsson, Department of Anatomy and Physiology, Box 7045, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.

Abstract

Aim:  This study investigated if the plasma vasopressin concentration increases during labour in the dog and whether the change in vasopressin correlates with that of oxytocin, 15-ketodihydro-PGF2α and cortisol.

Methods:  Five beagle dogs each delivered three to seven puppies. Blood samples were taken from a catheter inserted into the cephalic vein during labour and by venepuncture during the other periods.

Results:  Vasopressin concentration increased from 2 ± 0 pmol L−1 (anoestrus) to 26 ± 11 pmol L−1 at the birth of the first puppy, remained high at the birth of the second puppy and then decreased. Oxytocin increased from 63 ± 5 pmol L−1 (anoestrus) to 166 ± 19 pmol L−1 at the birth of the first puppy and remained elevated throughout labour. The PGF2α metabolite concentration increased from 0.2 ± 0.0 nmol L−1 (anoestrus) to 66 ± 17 nmol L−1 at the birth of the first puppy and remained elevated 1 h after the completion of parturition. The cortisol concentration increased from 49 ± 9 nmol L−1 (anoestrus) to 242 ± 35 nmol L−1 at the birth of the first puppy, remained high during the birth of the second puppy and then declined.

Conclusions:  The plasma level of vasopressin was strongly correlated with that of cortisol but less with that of the PGF2α metabolite, and not significantly with the concentration of oxytocin. This indicates that the four hormones play different roles during labour in the dog.

Ancillary