Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day
Article first published online: 5 NOV 2003
Acta Psychiatrica Scandinavica
Volume 108, Issue 6, pages 432–438, December 2003
How to Cite
Perlis, R. H., Alpert, J., Nierenberg, A. A., Mischoulon, D., Yeung, A., Rosenbaum, J. F. and Fava, M. (2003), Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day. Acta Psychiatrica Scandinavica, 108: 432–438. doi: 10.1046/j.0001-690X.2003.00168.x
- Issue published online: 5 NOV 2003
- Article first published online: 5 NOV 2003
- Accepted for publication April 9, 2003
- antidepressive agents;
- lithium carbonate;
Objective: Patients with major depressive disorder often show only partial or no response to antidepressants, necessitating next-step interventions such as dose increase or augmentation. Factors moderating response to these next-step interventions are not well-studied.
Method: In this randomized, double-blind investigation of next-step treatments in 101 outpatients who failed to respond to fluoxetine 20 mg for 8 weeks, the impact of depressive course and sociodemographic factors on likelihood of treatment response following dose increase or lithium or desipramine augmentation was examined.
Results: After controlling for depression severity at baseline, current marriage and earlier onset of depression were associated with greater likelihood of response in a logistic regression. Intervention strategy was not predictive of response.
Conclusion: Marital status and earlier onset of depression may be clinically useful in predicting outcome following any next-step intervention for treatment resistance, rather than with particular strategies.