You have full text access to this OnlineOpen article
Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease
Article first published online: 28 DEC 2001
DOI: 10.1046/j.0022-3042.2001.00676.x
Additional Information
How to Cite
Duan, W., Ladenheim, B., Cutler, R. G., Kruman, I. I., Cadet, J. L. and Mattson, M. P. (2002), Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. Journal of Neurochemistry, 80: 101–110. doi: 10.1046/j.0022-3042.2001.00676.x
Publication History
- Issue published online: 28 DEC 2001
- Article first published online: 28 DEC 2001
- Received August 29, 2001; revised manuscript received October 4, 2001; accepted October 5, 2001.
References
- , , , , and (1995) Sulfate and cysteine levels in the plasma␣of␣patients with Parkinson's disease. Neurotoxicology 16, 527–529.
- , , , , and (1992) Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur. J. Clin. Invest. 22, 79–87.Direct Link:
- and (1993) Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2′-aminophenyl)-1,2,3,6-tetrahydropyridine (2′-NH2-MPTP): a comparative study with 2′-CH3-MPTP and MPTP. J. Neurochem. 60, 1167–1170.
- and (1999) Titrating the effects of mitochondrial complex I impairment in the cell physiology. J. Biol. Chem. 274, 16188–16197.
- , , , , and (1995) Hyperhomocysteinaemia; with reference to its neuroradiological aspects. Neuroradiology 37, 403–411.DOI: 10.1007/s002340050119
- , , , , and (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3, 1301–1306.
- , , and (1997) Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice. Exp. Neurol. 148, 288–292.
- , , , , , , , and (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implication for cancer and neuronal damage. Proc. Natl Acad. Sci. USA 94, 3290–3295.
- , , , and (1994) Homocysteine and cysteine: determinants of plasma levels␣in middle aged and elderly subjects. J. Intern. Med. 236, 633–641.Direct Link:
- , , and (2000) Impaired iron homeostasis in Parkinson's disease. J. Neural. Transm. Supplement 60, 37–58.
- and (1999) Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J.␣Neurosci. Res. 57, 195–206. Direct Link:
- , , and (1999) Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease. Ann. Neurol. 46, 587–597.DOI: 10.1002/1531-8249(199910)46:4<587::AID-ANA6>3.0.CO;2-MDirect Link:
- and (1998) Stroke risk factors and stroke prevention. Semin. Neurol. 18, 429–440.
- (1990) Methionine metabolism in mammals. J. Nutr. Biochem. 1, 228–237.
- , , , and (1988) The histological effects of intracerebral injection or infusion of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and MPP+ (1-methyl-4-phenylpyridinium) in rat and mouse. Brain. Res. 461, 361–366.
- , , , and (1995) Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study. Stroke 26, 1166–1170.
- , and (1994) Folic acid in neurodevelopment and child psychiatry. Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 647–660.
- , and (1992) Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: kinetic characterisation and analysis of carrier specificity. J. Neurosci. Res. 32, 60–68.Direct Link:
- , , , , , , and (1999) Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc. Natl Acad. Sci. USA 96, 4125–4130.
- , , , and (1999) Age-related psychomotor and spatial learning deficits in 129/SvJ mice. Neurobiol. Aging 20, 9–18.
- and (1998) Understanding cell death in Parkinson's disease. Ann. Neurol. 44, S72–S84.
- , , , and (1997) Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17, 5089–5100.
- , , , , , and (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 20, 6920–6926.
- , , , , , , , and (1998) Elevated plasma levels of homocysteine in Parkinson's disease. Eur. Neurol. 40, 225–227.
- (1987) Parkinson's disease: current view. Am. Fam. Phys. 35, 201–206.
- (1998) Epidemiology versus genetics in Parkinson's disease: progress in resolving an age-old debate. Ann. Neurol. 44, S45–S52.
- , , , and (1999) Pesticides and Parkinson's disease. Biomed. Pharmacother. 53, 122–130.
- , , , , , , and (1997) Neurotoxicity␣associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor. Proc. Natl Acad. Sci. USA 94, 5923–5928.
- , , , , and (1996) Dietary lipids and antioxidants in Parkinson's disease:␣a␣population-based, case-control study. Ann. Neurol. 39, 89–94.Direct Link:
- (2000) Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol. Genet. Metab. 71, 121–138.
- (1994) Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 57, 672–681.
- and (1998) Homocysteine and vascular disease: nature or nurture? J. Cardiovasc. Risk 5, 233–237.
- , , , , and (1997) Effect of 1-dopa and the catechol-O-methyltransferase inhibitor Ro 41–0960 on sulfur amino acid metabolites in rats. Clin. Neuropharmacol. 20, 55–66.
- , , , , and (1992) Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl Acad. Sci. USA 89, 3859–3863.
- , , , and (2001) Decrease of methionine and S-adnenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease. Neurosci. Lett. 308, 54–56.
- , , and (1998) Homocysteine and cardiovascular disease. Annu. Rev. Med. 49, 31–62.
- , , , , , and (1997) Dietary antioxidants and Parkinson disease. The Rotterdam Study. Arch. Neurol. 54, 762–765.
- , and (1987) Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons␣in the monkey following exposure to MPTP. Brain Res. 411, 144–150.
- and (1998) Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry. J.␣Cardiovasc. Risk 5, 223–227.
- , and (1998) Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins. Brain Res. 809, 12–17.
- , and (2000) The genetics of Parkinson's disease. Curr. Opin. Genet. Dev. 10, 292–298.
- , and (1997) Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine β-synthase deficiency: the effect of treatment. Pediatr. Res. 42, 577–582.
- (2000) Increased caspase 3 and bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp. Neurol. 166, 29–43.
- , , , , , and (1999) Environmental, medical, and family history risk factors for Parkinson's disease: a New England-based case control study. Am. J. Med. Genet. 88, 742–749.Direct Link:
- , , , and (1996) Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system. J. Neurosci. 16, 7416–7427.
- and (1989) Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity. Am. J. Med. Genet. 34, 427–434.Direct Link:
- and (1998) Homocysteine and atherothrombosis. N. Engl. J. Med. 338, 1042–1050.
- , , , and (2000) Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology 55, 437–440.
- , , and (1998) Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. J.␣Neurosci. Res. 53, 613–625. Direct Link:

1471-4159/asset/olbannerleft.gif?v=1&s=4636ca86ad7e40d133e71d09a5d759010472e0c2)
1471-4159/asset/olbannerright.gif?v=1&s=38094197c2d87aeb3b86aa293b5858c5c15cca29)
1471-4159/asset/cover.gif?v=1&s=4f99ec10d4bac18b4327882ae87f581a11d8dd49)