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Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival

  1. Rugao Liu1,2,
  2. Baolin Li3,
  3. Shawn W. Flanagan4,
  4. Larry W. Oberley4,
  5. David Gozal1,
  6. Mengsheng Qiu2

Article first published online: 21 JAN 2002

DOI: 10.1046/j.0022-3042.2001.00720.x

Issue

Journal of Neurochemistry

Journal of Neurochemistry

Volume 80, Issue 3, pages 488–500, February 2002

Additional Information

How to Cite

Liu, R., Li, B., Flanagan, S. W., Oberley, L. W., Gozal, D. and Qiu, M. (2002), Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival. Journal of Neurochemistry, 80: 488–500. doi: 10.1046/j.0022-3042.2001.00720.x

Author Information

  1. 1

    Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA

  2. 2

    Department of Anatomy and Neurobiology, University of Louisville, Louisville, Kentucky, USA

  3. 3

    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indianapolis, USA

  4. 4

    Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa, USA

*Address correspondence and reprint requests to Dr Rugao Liu, Kosair Children's Hospital Research Institute, Department of Pediatrics, 570 S. Preston St., Suite 321, University of Louisville, Louisville, KY 40202, USA. E-mail: r0Liu002@gwise.louisville.edu

Publication History

  1. Issue published online: 21 JAN 2002
  2. Article first published online: 21 JAN 2002
  3. Resubmitted manuscript received November 6, 2001;␣accepted␣November 6, 2001.

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