Human papillomavirus-negative ileostomal chronic papillomatous dermatitis
Article first published online: 7 JUL 2008
Journal of Cutaneous Pathology
Volume 30, Issue 4, pages 271–274, April 2003
How to Cite
Williams, C. M., Wieland, U., Rodning, C. B. and Horenstein, M. G. (2003), Human papillomavirus-negative ileostomal chronic papillomatous dermatitis. Journal of Cutaneous Pathology, 30: 271–274. doi: 10.1046/j.0303-6987.2003.048.x
- Issue published online: 7 JUL 2008
- Article first published online: 7 JUL 2008
- Accepted November 6, 2002
Background: Papillomatous stoma-related skin lesions may result from irritant reactions or infection with epidermodysplasia verruciformis human papillomavirus (HPV) types.
Methods: We report upon a papillomatous lesion at the ileostoma of a 63-year-old male with familial adenomatous polyposis and colorectal adenocarcinoma. We thoroughly tested the lesion for HPV using immunohistochemistry, transmission electron microscopy, and polymerase chain reaction analyses.
Results: The lesion was a fleshy, multilobulated, and verrucous plaque, with hyperkeratosis, hypergranulosis, acanthosis and marked papillomatosis. The clinical and light microscopic features were suggestive of a condyloma. However, no HPV was detected.
Conclusions: We suggest that the lesion most likely represents chronic papillomatous dermatitis, a reaction to mechanical and/or chemical irritation usually associated with urostomies and only rarely observed with ileostomies. This case highlights the clinical, diagnostic and therapeutic aspects of an unusual cutaneous morbidity associated with ileostomies.