Herb–drug interactions: Review and assessment of report reliability
Article first published online: 20 DEC 2001
British Journal of Clinical Pharmacology
Volume 52, Issue 5, pages 587–595, November 2001
How to Cite
Fugh-Berman, A. and Ernst, E. (2001), Herb–drug interactions: Review and assessment of report reliability. British Journal of Clinical Pharmacology, 52: 587–595. doi: 10.1046/j.0306-5251.2001.01469.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- Received 25 November 2000,accepted 29 June 2001.
- alternative medicine;
- herbal medicine;
Aims The aim of this systematic review was to assess the published clinical evidence on interactions between herbal and conventional drugs.
Methods Four electronic databases were searched for case reports, case series or clinical trials of such interactions. The data were extracted and validated using a scoring system for interaction probability.
Results One hundred and eight cases of suspected interactions were found. 68.5% were classified as ‘unable to be evaluated’, 13% as ‘well-documented’ and 18.5% as ‘possible’ interactions. Warfarin was the most common drug (18 cases) and St John's wort the most common herb (54 cases) involved.
Conclusion Herb–drug interactions undoubtedly do occur and may put individuals at risk. However our present knowledge is incomplete and more research is urgently needed.