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Reactivity to autologous serum skintest and clinical features in chronic idiopathic urticaria

Authors

  • E. Nettis,

    1. Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, Chair of Medical Statistics, University of Bari, Italy
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  • P. Dambra,

    1. Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, Chair of Medical Statistics, University of Bari, Italy
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  • L. D'Oronzio,

    1. Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, Chair of Medical Statistics, University of Bari, Italy
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  • E. Cavallo,

    1. Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, Chair of Medical Statistics, University of Bari, Italy
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  • M. P. Loria,

    1. Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, Chair of Medical Statistics, University of Bari, Italy
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  • M. Fanelli,

    1. Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, Chair of Medical Statistics, University of Bari, Italy
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  • A. Ferrannini,

    1. Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, Chair of Medical Statistics, University of Bari, Italy
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  • A. Tursi

    1. Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, Chair of Medical Statistics, University of Bari, Italy
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: E. Nettis, Cattedra di Allergologia e Immunologia Clinica, Padiglione Chini – Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy. Tel.: +39 0805592281. Fax: +39 0805478780. E-mail: e.nettis@allergy.uniba.it

Abstract

Summary The autologous-serum skin test (ASST) can cause a wheal-and-flare response in some cases of chronic idiopathic urticaria. We subjected 102 patients affected by chronic idiopathic urticaria to this test and studied some clinical parameters to detect any significant differences between ASST-positive and ASST-negative patients. The only significant difference we noted between the two groups was the incidence of angioedema (P = 0.01). We suggest that the ASST cannot be used alone either to predict the severity of urticaria or to define it as ‘autoimmune’.

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