Lowering the extracellular potassium concentration elicits epileptic activity in neocortical tissue of epileptic patients


: Dr Ali Gorji, as above.
E-mail: gorjial@uni-muenster.de


The increase in the extracellular potassium concentration ([K+]o) is a well-established model of epilepsy (the so-called high potassium model). Therefore, it is generally accepted that for the prevention of abnormal excitability and seizure generation, increases of [K+]o must be avoided. In this paper, however, we show that on the contrary, a reduction of [K+]o also elicits epileptic activity in brain slices of man.