Substance P: a pioneer amongst neuropeptides
Article first published online: 20 DEC 2001
Journal of Internal Medicine
Volume 249, Issue 1, pages 27–40, January 2001
How to Cite
Hökfelt, T., Pernow, B. and Wahren, J. (2001), Substance P: a pioneer amongst neuropeptides. Journal of Internal Medicine, 249: 27–40. doi: 10.1046/j.0954-6820.2000.00773.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- sensory neurones
Abstract. Hökfelt T, Pernow B, Wahren J (Karolinska Institutet, Stockholm, Sweden). Substance P: a pioneer amongst neuropeptides. J Intern Med 2001; 249: 27–40.
A brief overview of recent developments in the substance P field is provided, in addition to a historical introduction. It is emphasized that there are multiple tachykinins and tachykinin receptors and that there are examples of coexistence of several tachykinin peptides and of several tachykinin receptors in single cells, and there is evidence for tachykininergic cotransmission. The distribution and functional significance of tachykinins in the gastrointestinal tract and in sensory neurones, and interactions with other peptides and transmitters, are reviewed. The recent production of knock-out mice for either substance P or the NK1 receptor is discussed, as well as the exciting concept of substance P receptor internalization. Finally, the development of specific substance P antagonists is summarized, and possible clinical implications discussed, and, in particular, a recent study which reports that a substance P antagonist shows clinical efficacy in depression.