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Evidence for an intrarenal renin-angiotensin system in the European lesser-spotted dogfish

Authors

  • A. Wells,

    Corresponding author
    1. School of Biology, Gatty Marine Laboratory, University of St Andrews, St Andrews, Fife, KY16 8LB, U.K.
      *Tel.: +44 (0) 1334 463485; fax: +44 (0) 1334 463443; e-mail: aw23@st-andrews.ac.uk
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  • W. G. Anderson,

    1. School of Biology, Gatty Marine Laboratory, University of St Andrews, St Andrews, Fife, KY16 8LB, U.K.
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  • N. Hazon

    1. School of Biology, Gatty Marine Laboratory, University of St Andrews, St Andrews, Fife, KY16 8LB, U.K.
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*Tel.: +44 (0) 1334 463485; fax: +44 (0) 1334 463443; e-mail: aw23@st-andrews.ac.uk

Abstract

The existence of an intrarenal renin-angiotensin system (RAS) in a perfused European lesser-spotted dogfish Scyliorhinus canicula trunk preparation was examined by the inhibition of angiotensin-converting enzyme by captopril. This resulted in a glomerular diuresis, an increase in urea and chloride clearance and excretion, and an increase in transport maxima for glucose. It is proposed that these results suggest the presence of an intrarenal RAS.

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