Direct measurement of alcohol and its metabolites
Article first published online: 14 NOV 2003
Special Issue: Self Report and Biochemical Measures of Alcohol Consumption
Volume 98, Issue Supplement s2, pages 73–80, December 2003
How to Cite
Swift, R. (2003), Direct measurement of alcohol and its metabolites. Addiction, 98: 73–80. doi: 10.1046/j.1359-6357.2003.00605.x
- Issue published online: 30 NOV 2009
- Article first published online: 14 NOV 2003
Background Ethanol can be easily and accurately measured in body fluids or vapours by several chemical and enzymatic methods. However, the persistence of ethanol in the body is short lived and ethanol's metabolism and distribution within the body are extremely complex.
Aim This article discusses the complex pharmacokinetics of ethanol and how pharmacokinetics can affect measured ethanol concentrations when ethanol is sampled across different individuals or from different body fluids or vapors, such as whole blood, plasma, breath, urine, saliva, or transdermal ethanol.
Findings Several physical methods for the quantification of ethanol concentrations are described, including gas chromatography, electrochemical detection, infrared detection and enzymatic methods, along with their advantages and limitations. Also discussed, is the utility of the measurement of several immediate metabolites of ethanol, including acetaldehyde, acetate, and fatty acid ethyl esters.
Conclusions The complex distribution and metabolism of ethanol and its metabolites can obscure the relationship between the ethanol concentration that is measured in body fluids or vapours and the amount of ethanol that is actually taken into the body.