A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat

Authors

  • A. L. Mark,

    1. Specialized Center of Research in Hypertension Genetics; the Department of Internal Medicine; and the Cardiovascular Research Center at the University of Iowa Roy J. and Lucille A. Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA, USA
    Search for more papers by this author
  • K. Rahmouni,

    1. Specialized Center of Research in Hypertension Genetics; the Department of Internal Medicine; and the Cardiovascular Research Center at the University of Iowa Roy J. and Lucille A. Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA, USA
    Search for more papers by this author
  • M. Correia,

    1. Specialized Center of Research in Hypertension Genetics; the Department of Internal Medicine; and the Cardiovascular Research Center at the University of Iowa Roy J. and Lucille A. Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA, USA
    Search for more papers by this author
  • W. G. Haynes

    1. Specialized Center of Research in Hypertension Genetics; the Department of Internal Medicine; and the Cardiovascular Research Center at the University of Iowa Roy J. and Lucille A. Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA, USA
    Search for more papers by this author

A. L. Mark MD, 218 CMAB, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1101, USA.

Abstract

Aim:  This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop.

Results:  Leptin increases sympathetic nerve activity to brown adipose tissue, kidney and other tissues. This action has implications for regulation of arterial pressure. In turn, there is evidence that sympathoadrenal stimulation inhibits leptin mRNA expression and secretion from white adipose tissue through beta adrenergic mechanisms.

Conclusion:  This sympathetic modulation of leptin expression has potential implications for regulation of body fat.

Ancillary