Aim: This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop.
Results: Leptin increases sympathetic nerve activity to brown adipose tissue, kidney and other tissues. This action has implications for regulation of arterial pressure. In turn, there is evidence that sympathoadrenal stimulation inhibits leptin mRNA expression and secretion from white adipose tissue through beta adrenergic mechanisms.
Conclusion: This sympathetic modulation of leptin expression has potential implications for regulation of body fat.