The influence of local skin temperature (Tskl) on the control of local and whole-body sweating was evaluated in eight healthy males. A water-perfusion garment (37 °C) and a climatic chamber (36.45 ± 0.78 °C; [±SD]; relative humidity 60.3 ± 1.6%) were used to raise and clamp skin and core temperatures. Warm and cool stimuli were applied to four upper-body skin regions (face, arm, forearm, hand) using perfusion patches (249.0 ± 0.2 cm2). Heating elevated, while cooling suppressed sweat rate (m˙sw) locally, and at other skin surfaces. However, the tendency for Tskl manipulations to induce localized sweat responses was no more powerful than it was at stimulating sweating in non-treated regions (P > 0.05). Accordingly, neither thermal stimulus produced significantly greater local sudomotor influences than were elicited contralaterally (P > 0.05). No statistical support was found for the notion of inter-regional differences in upper-body cutaneous thermal sensitivity for sudomotor control, and, regardless of the stimulation site, whole-body sudomotor responses to localized thermal treatments were equivalent (P > 0.05).