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Effect of acid suppression therapy on development of gastric erosions after cure of Helicobacter pylori infection

  1. K. Miyake1,
  2. T. Tsukui1,
  3. S. Futagami1,
  4. A. Tatsuguchi1,
  5. K. Shinoki1,
  6. T. Hiratsuka1,
  7. T. Iizumi1,
  8. K. Nagata1,
  9. Y. Shinji1,
  10. K. Wada1,
  11. N. Yamada2,
  12. M. Kobayashi1,
  13. C. Sakamoto1

Article first published online: 20 APR 2002

DOI: 10.1046/j.1365-2036.16.s2.14.x

Issue

Alimentary Pharmacology & Therapeutics

Alimentary Pharmacology & Therapeutics

Volume 16, Issue Supplement s2, pages 210–216, April 2002

Additional Information

How to Cite

Miyake, K. , Tsukui, T. , Futagami, S. , Tatsuguchi, A. , Shinoki, K. , Hiratsuka, T. , Iizumi, T. , Nagata, K. , Shinji, Y. , Wada, K. , Yamada, N. , Kobayashi, M. and Sakamoto, C. (2002), Effect of acid suppression therapy on development of gastric erosions after cure of Helicobacter pylori infection. Alimentary Pharmacology & Therapeutics, 16: 210–216. doi: 10.1046/j.1365-2036.16.s2.14.x

Author Information

  1. 1

    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan,

  2. 2

    Department of Pathology, Nippon Medical School, Tokyo, Japan

* Dr K. Miyake, Third Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.

Publication History

  1. Issue published online: 20 APR 2002
  2. Article first published online: 20 APR 2002

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Background:

Helicobacter pylori eradication markedly improves histological inflammation and decreases peptic ulcer recurrence, but little is known about the subsequent development of gastric mucosal injury.

Aim:

To investigate whether acid suppression treatment after eradication influences the development of gastric erosions.

Methods:

Eighty-one patients (gastritis or peptic ulcer) after successful H. pylori eradication were divided into two groups: 40 received an H2-blocker for 6 months (H2-blocker-positive) and 41 received no treatment (H2-blocker-negative). Endoscopy was performed before, and at 3 and 6 months after completion of eradication.

Results:

Cumulative prevalence of gastric erosions in the H2-blocker-positive group was significantly lower than in the H2-blocker-negative group, 25% vs. 42%, respectively. In the H2-blocker-negative group but not the H2-blocker-positive group, the cumulative prevalence of gastric erosions after eradication was higher in patients with less severe corpus atrophy or more severe corpus gastritis.

Conclusions:

Development of gastric erosions after H. pylori eradication may be controlled by acid suppression treatment. Less severe atrophy or more severe gastritis in oxyntic glands before eradication may be involved in the development of gastric erosions. These results support the idea that recovery of acid secretion may be one of factors for development of gastric mucosal erosions after successful eradication.

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