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Sensitivity of biopsy site in evaluating regression of gastric atrophy after Helicobacter pylori eradication treatment

  1. T. Sugiyama1,
  2. N. Sakaki1,
  3. H. Kozawa2,
  4. R. Sato1,
  5. T. Fujioka3,
  6. K. Satoh1,
  7. K. Sugano4,
  8. H. Sekine5,
  9. A. Takagi6,
  10. Y. Ajioka7,
  11. T. Takizawa8,
  12. For The H. Pylori Forum Gastritis Study Group1

Article first published online: 20 APR 2002

DOI: 10.1046/j.1365-2036.16.s2.17.x

Issue

Alimentary Pharmacology & Therapeutics

Alimentary Pharmacology & Therapeutics

Volume 16, Issue Supplement s2, pages 187–190, April 2002

Additional Information

How to Cite

Sugiyama, T. , Sakaki, N. , Kozawa, H. , Sato, R. , Fujioka, T. , Satoh, K. , Sugano, K. , Sekine, H. , Takagi, A. , Ajioka, Y. , Takizawa, T. and For The H. Pylori Forum Gastritis Study Group (2002), Sensitivity of biopsy site in evaluating regression of gastric atrophy after Helicobacter pylori eradication treatment. Alimentary Pharmacology & Therapeutics, 16: 187–190. doi: 10.1046/j.1365-2036.16.s2.17.x

Author Information

  1. 1

    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Japan,

  2. 2

    Department of Gastroenterology, Tokyo Metropolitan Komagome Hospital, Japan,

  3. 3

    Department of Primary Care, Oita Medical University, Japan,

  4. 4

    Department of Gastroenterology, Jichi Medical University, Japan,

  5. 5

    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Japan,

  6. 6

    Department of Gastroenterology, Tokai University School of Medicine, Japan,

  7. 7

    Department of Pathology, Niigata University School of Medicine, Japan,

  8. 8

    Department of Pathology, Tokyo Medical and Dental University School of Medicine, Japan

* Dr T. Sugiyama, Department of Gastroenterology, Hokkaido University Graduate School of Medicine, N-15, W-7, Kita-ku, 060-8638, Sapporo, Japan. E-mail: tsugi@med.hokudai.ac.jp

Publication History

  1. Issue published online: 20 APR 2002
  2. Article first published online: 20 APR 2002

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Background:

Helicobacter pylori infection is a major cause of the progress of gastric glandular atrophy, a high-risk background factor in the development of gastric cancer. Regression of gastric atrophy is critical to prevention of cancer by H. pylori eradication treatment. However, it is controversial whether gastric atrophy regresses after H. pylori eradication.

Aim:

To determine the most sensitive and appropriate biopsy site for evaluation of regression of atrophy after treatment.

Subjects and methods:

Thirty-eight patients who showed regression of gastric atrophy in histology after treatment were investigated. Four biopsy specimens from the lesser and greater curvatures in the antrum and corpus were evaluated before and after treatment according to the Updated Sydney System.

Results:

Regression of atrophy after treatment was seen in 30 of 38 biopsy specimens from the lesser curvature of the corpus (79%), and this site was most sensitive. Odds ratio of this site to the others was 8.28. Regression of atrophy in this site was observed at 12.2 months in the younger patients and 15.9 months in the elder patients.

Conclusion:

Biopsy sampling from the lesser curvature of the corpus is the most sensitive and appropriate for evaluation of regression of gastric atrophy after H. pylori eradication treatment.

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