Helicobacter pylori eradication using a 7-day regimen of low-dose clarithromycin, lansoprazole and amoxycillin
Article first published online: 14 NOV 2003
Alimentary Pharmacology & Therapeutics
Volume 11, Issue 3, pages 537–540, June 1997
How to Cite
Lim, A. G., Walker, C., Chambers, S. and Gould, S. R. (1997), Helicobacter pylori eradication using a 7-day regimen of low-dose clarithromycin, lansoprazole and amoxycillin. Alimentary Pharmacology & Therapeutics, 11: 537–540. doi: 10.1046/j.1365-2036.1997.00184.x
- Issue published online: 14 NOV 2003
- Article first published online: 14 NOV 2003
To evaluate the efficacy of a 7-day regimen of clarithromycin 250 mg b.d., amoxycillin 1 g b.d., and lansoprazole 30 mg b.d. as a treatment for Helicobacter pylori infection.
H. pylori status of dyspeptic patients was assessed by 13C-urea breath test and at endoscopy by histology, culture and rapid urease testing of gastric biopsies. Fifty-one H. pylori-positive patients were treated with the above regimen. H. pylori status was reassessed by 13C -urea breath test not less than 28 days after completing treatment. Adverse events and compliance were evaluated.
On an intention-to-treat basis, H. pylori infection was cured in 77% (95% CI: 65–88%) of patients. Minor side-effects including diarrhoea, nausea and taste disturbance were reported by 64% of patients. Ninety-five per cent of patients consumed > 95% of tablets. Metronidazole resistance was 29% but all cultures were sensitive to amoxycillin and clarithromycin.
This 7-day treatment with low-dose clarithromycin was moderately effective in curing H. pylori infection. Although compliance was excellent, there was a high frequency of minor adverse events.