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Helicobacter pylori eradication using a 7-day regimen of low-dose clarithromycin, lansoprazole and amoxycillin

  1. A. G. Lim1,
  2. C. Walker1,
  3. S. Chambers2,
  4. S. R. Gould1

Article first published online: 14 NOV 2003

DOI: 10.1046/j.1365-2036.1997.00184.x

Issue

Alimentary Pharmacology & Therapeutics

Alimentary Pharmacology & Therapeutics

Volume 11, Issue 3, pages 537–540, June 1997

Additional Information

How to Cite

Lim, A. G., Walker, C., Chambers, S. and Gould, S. R. (1997), Helicobacter pylori eradication using a 7-day regimen of low-dose clarithromycin, lansoprazole and amoxycillin. Alimentary Pharmacology & Therapeutics, 11: 537–540. doi: 10.1046/j.1365-2036.1997.00184.x

Author Information

  1. 1

    Departments of Gastroenterology, Epsom Healthcare NHS Trust and PHLS Laboratory, Epsom, Surrey, UK

  2. 2

    Departments of Microbiology, Epsom Healthcare NHS Trust and PHLS Laboratory, Epsom, Surrey, UK

*S. R. Gould, Department of Gastroenterology, Epsom General Hospital, Dorking Road, Epsom, Surrey KT18 7EG, UK.

Publication History

  1. Issue published online: 14 NOV 2003
  2. Article first published online: 14 NOV 2003

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Aim:

To evaluate the efficacy of a 7-day regimen of clarithromycin 250 mg b.d., amoxycillin 1 g b.d., and lansoprazole 30 mg b.d. as a treatment for Helicobacter pylori infection.

Methods:

H. pylori status of dyspeptic patients was assessed by 13C-urea breath test and at endoscopy by histology, culture and rapid urease testing of gastric biopsies. Fifty-one H. pylori-positive patients were treated with the above regimen. H. pylori status was reassessed by 13C -urea breath test not less than 28 days after completing treatment. Adverse events and compliance were evaluated.

Results:

On an intention-to-treat basis, H. pylori infection was cured in 77% (95% CI: 65–88%) of patients. Minor side-effects including diarrhoea, nausea and taste disturbance were reported by 64% of patients. Ninety-five per cent of patients consumed > 95% of tablets. Metronidazole resistance was 29% but all cultures were sensitive to amoxycillin and clarithromycin.

Conclusion:

This 7-day treatment with low-dose clarithromycin was moderately effective in curing H. pylori infection. Although compliance was excellent, there was a high frequency of minor adverse events.

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