Effects of somatostatin on proximal gastric motor function and visceral perception

Authors


Masclee Department of Gastroenterology–Hepatology, Leiden University Medical Center, Building 1, C4-P, PO Box 9600, 2300 RC Leiden, the Netherlands.

Abstract

Background:

Somatostatin affects gastrointestinal motility and secretion and visceral sensation, but little is known about its effects on the proximal stomach.

Aim:

To evaluate the effects of somatostatin on proximal gastric motor function and perception of symptoms.

Methods:

Six healthy subjects participated in two experiments performed in random order during continuous intravenous infusion of saline or somatostatin (250 μg/h). Proximal gastric motor function was evaluated using a barostat. We performed pressure and volume distensions and a barostat procedure (minimal distending pressure + 2 mmHg). Symptoms were evaluated at regular intervals using visual analogue scales (VAS).

Results:

Neither minimal distending pressure nor gastric fundal tone were significantly different between somatostatin and saline. Pressure–volume curves during distensions were not influenced by somatostatin. However, phasic volume waves were significantly (< 0.001) reduced by somatostatin, and somatostatin significantly (< 0.05) reduced symptom perception of fullness and abdominal pressure during stepwise distensions.

Conclusions:

Continuous infusion of somatostatin does not influence gastric compliance but it inhibits phasic volume waves and significantly reduces visceral perception.

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