The efficacy of octreotide therapy in chronic bleeding due to vascular abnormalities of the gastrointestinal tract
Article first published online: 24 DEC 2001
Alimentary Pharmacology & Therapeutics
Volume 13, Issue 11, pages 1429–1436, November 1999
How to Cite
Nardone, Rocco, Balzano and Budillon (1999), The efficacy of octreotide therapy in chronic bleeding due to vascular abnormalities of the gastrointestinal tract. Alimentary Pharmacology & Therapeutics, 13: 1429–1436. doi: 10.1046/j.1365-2036.1999.00647.x
- Issue published online: 24 DEC 2001
- Article first published online: 24 DEC 2001
: The treatment of angiodysplasia and watermelon stomach, vascular abnormalities implicated in gastrointestinal bleeding of obscure origin, is a major clinical problem.
: To determine the efficacy of octreotide in patients with long-standing gastrointestinal bleeding due to acquired angiodysplasia and watermelon stomach, resistant to previous treatments and not suitable for surgery because of old age and/or concomitant disorders.
Patients and methods
: We treated 17 patients (seven had isolated angiodysplasia, seven had multiple upper and lower gastrointestinal angiodysplasia, and three had watermelon stomach) with octreotide (0.1 mg subcutaneous t.d.s. for 6 months). Six of the patients had liver cirrhosis, one had Glanzmann-type platelet derangement, two had cardiovascular diseases and one had chronic uraemia.
: Octreotide treatment stopped bleeding in 10 patients. A transient improvement was observed in four, who needed subsequent cyclical retreatment to correct low haemoglobin levels. No effect was observed in three, probably due to the severity of the concomitant disorders.
: Octreotide is a safe drug that may be useful to control the recurrent gastrointestinal bleeding due to acquired angiodysplasia and watermelon stomach, especially in patients who are not candidates for surgery due to old age and/or concomitant disorders.