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Helicobacter pylori infection influences nocturnal gastric acid breakthrough
Article first published online: 24 DEC 2001
DOI: 10.1046/j.1365-2036.2000.00799.x
1365-2036/asset/cover.gif?v=1&s=d621428d7905f55dc6cbe431b6da6a6c8f16399c "Alimentary Pharmacology & Therapeutics")
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How to Cite
Katsube, T., Adachi, K., Kawamura, A., Amano, K., Uchida, Y., Watanabe, M. and Kinoshita, Y. (2000), Helicobacter pylori infection influences nocturnal gastric acid breakthrough. Alimentary Pharmacology & Therapeutics, 14: 1049–1056. doi: 10.1046/j.1365-2036.2000.00799.x
Publication History
- Issue published online: 24 DEC 2001
- Article first published online: 24 DEC 2001
- Abstract
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Background:
Nocturnal gastric acid breakthrough is defined as night-time periods when gastrin pH falls below 4.0 for greater than 1h during administration of a proton pump inhibitor. This phenomenon is a serious problem for patients who require strict control of their gastric acid secretions.
Aim:
To investigate the prevalence of nocturnal gastric acid breakthrough in Japanese subjects during administration of rabeprazole, and to clarify the relationship between Helicobacter pylori infection and nocturnal gastric acid breakthrough.
Methods:
Thirty-one normal male volunteers were examined by ambulatory 24 h gastric pH monitoring four times: without medication, after a morning or an evening dose of 20 mg rabeprazole, and after administration of an H2-receptor antagonist at bedtime, in addition to the morning dose of rabeprazole. H. pylori infection was determined by the 13C-urea breath test and an assay for serum anti-H. pylori antibody.
Result:
Nocturnal gastric acid breakthrough was observed in 12 patients (39%) after the morning dose of 20 mg rabeprazole. In all cases, nocturnal gastric acid breakthrough was inhibited completely by administration of the H2-receptor antagonist at bedtime. Only one patient with nocturnal gastric acid breakthrough had H. pylori infection.
Conclusion:
The absence of H. pylori infection appears to be closely related to the occurrence of nocturnal gastric acid breakthrough during dosing with a proton pump inhibitor.