• 1
    The European Helicobacter pylori Study Group. Current European concepts in management of Helicobacter pylori infection. The Maastricht Consensus Report. Gut 1997; 41: 813.
  • 2
    Lam SK, Talley NJ. Report of the 1997 Asia Pacific Consensus Conference on the management of Helicobacter pylori infection. J Gastroenterol Hepatol 1998; 13: 112.
  • 3
    Unge P. What other regimens are under investigation to treat Helicobacter pylori infection? Gastroenterology 1997; 113: S131S148.
  • 4
    Huang JQ, Hung RH. The importance of clarithromycin dose in the management of Helicobacter pylori infection: a meta-analysis of triple therapies with a proton pump inhibitor, clarithromycin and amoxycillin or metronidazole. Aliment Pharmacol Ther 1999; 13: 71929.
  • 5
    Gisbert JP, Calvet X, Gomollon F, Sainz R. Treatment for the eradication of Helicobacter pylori. Recommendations of the Spanish Consensus Conference. Med Clin (Barc.) 2000; 114: 18595.
  • 6
    Pipkin GA, Williamson R, Wood JR. Review article: one-week clarithromycin triple therapy regimens for eradication of Helicobacter pylori. Aliment Pharmacol Ther 1998; 12: 82337.
  • 7
    Clarke M, Oxman AD, eds. Cochrane Reviewers’s Handbook 4.0. In: Review Manager (RevMan) 4.0. Oxford, England: The Cochrane Collaboration, 1999.
  • 8
    Battaglia G, Benedetti E, Bottona E, et al. pantoprazole in eradication of peptic ulcer H. pylori positive patients: a multicenter randomized prospective study by GISU (Interdisciplinary Ulcer Study Group). Gastroenterology 1999; 116: A121A121(Abstract).
  • 9
    Cammarota G, Cianci R, Gasbarrini G. Eradication of Helicobacter pylori in routine clinical practice: doubts and uncertainties. Hepato-Gastroenterology 1999; 46: 3125.
  • 10
    Francheschi M, Pilotto A, Bozzola L, Di Mario F, Buda A, Valerio G. Lansoprazole, clarithromycin and/or amoxycillin and metronidazole for one-week to cure Helicobacter pylori in the elderly. Gastroenterology 1997; 112: A118A118(Abstract).
  • 11
    Frevel M, Daake H, Janisch HD, et al. Pantoprazole plus clarithromycin and metronidazole versus pantoprazole plus clarithromycin and amoxicillin for therapy of H. pylori infection. Gut 1997; 41(Suppl. 1): A103A103(Abstract).
  • 12
    Gisbert JP, Boixeda D, Aller R, De La Serna C, Sanz E, Martin de Argila, et al. Helicobacter pylori and bleeding duodenal ulcer: prevalence of the infection, efficacy of three triple therapies and role of eradication in the prevention of recurrent hemorrhage. Med Clin (Barc.) 1999; 112: 1615.
  • 13
    Harris AW, Misiewicz JJ, Bardhan KD, et al. Incidence of duodenal ulcer healing after 1 week of proton pump inhibitor triple therapy for eradication of Helicobacter pylori. The Lansoprazole Helicobacter Study Group. Aliment Pharmacol Ther 1998; 12: 7415.
  • 14
    Houben MH, Hensen EF, Rauws EA, et al. Randomized trial of omeprazole and clarithromycin combined with either metronidazole or amoxycillin in patients with metronidazole-resistant or -susceptible Helicobacter pylori strains. Aliment Pharmacol Ther 1999; 13: 8839.
  • 15
    Jonaitis L, Kupcinskas L, Kiudelis G, Cizauskas A. Insufficient results of eradication in high Helicobacter pylori prevalence region. Gut 1999; 45(Suppl. 3): A117A117(Abstract).
  • 16
    Laine L, Frantz JE, Baker A, Neil GAA. United States multicenter trial of dual and proton pump inhibitor-based triple therapies for Helicobacter pylori. Aliment Pharmacol Ther 1997; 11: 9137.
  • 17
    Lamouliatte H, Talbi P, Cayla R, Zerbib F, Mégraud F. Randomised study comparing two seven days triple therapies with lansoprazole and two low-dose of clarithromycin plus amoxicillin or tinidazole for H. pylori eradication. Gut 1996; 39(Suppl. 2): A35A35(Abstract).
  • 18
    Laurent J, Mégraud F, Flejou JF, Caekaert A, Barthelemy P. Comparison of 4 triple therapies combining omeprazole and 2 antibiotics for the eradication of Helicobacter pylori. Interest of bacampicillin and azithromycin. Gastroenterology 1999; 116: A120A120(Abstract).
  • 19
    Lee CL, Wu CH, Chen TK, et al. Comparison of metronidazole or amoxycillin based 1-week low dose triple therapy in the treatment of active duodenal ulcer: can pre-treatment urea breath test values predict the treatment outcome? Gut 1999; 45(Suppl. 3): A119A119(Abstract).
  • 20
    Lind T, Veldhuyzen van Zanten S, Unge P, et al. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study. Helicobacter 1996; 1: 13844.
  • 21
    Lind T, Mégraud F, Unge P, et al. The MACH2 study: role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies. Gastroenterology 1999; 116: 24853.
  • 22
    Malfertheiner P, Bayerdorffer E, Diete U, et al. The GU-MACH study: the effect of 1-week omeprazole triple therapy on Helicobacter pylori infection in patients with gastric ulcer. Aliment Pharmacol Ther 1999; 13: 70312.
  • 23
    Misiewicz JJ, Harris AW, Bardhan KD, et al. One week triple therapy for Helicobacter pylori: a multicenter comparative study. Lansoprazole Helicobacter Study Group Gut 1997; 41: 7359.
  • 24
    Perri F, Festa V, Clemente R, et al. Failure of standard triple therapies for H. pylori eradication in dyspeptic outpatients. Gastroenterology 1999; 116: A280A280(Abstract).
  • 25
    Sue M, Peura D, Charles C, et al. Comparison of two treatment strategies for the eradication of H. pylori utilizing a screening antibody serum blot test and confirmatory C14 test. Gastroenterology 1996; 110: A266A266(Abstract).
  • 26
    Susi D. The best treatment for Helicobacter pylori infection among four different 7-day triple therapies. Gut 1998; 43(Suppl. 2): A80A80(Abstract).
  • 27
    Susi D. Cost and efficacy of 7-day triple therapies for H. pylori eradication: PPI-based vs. RBC-based treatments. Gut 1999; 54(Suppl. 3): A106A106(Abstract).
  • 28
    Tzathas C, Petraki K, Amberadis P, et al. A prospective, randomized, controlled, investigator blind, single center trial comparing two one-week omeprazole triple therapies for healing peptic ulcer and eradication of H. pylori infection. Gut 1998; 43(Suppl. 2): A91A91(Abstract).
  • 29
    Veldhuyzen van Zanten SJO, Bradette M, Farley A, et al. The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy. Aliment Pharmacol Ther 1999; 13: 28995.
  • 30
    Laheij RJF, Van Rossum LGM, Jansen JBMJ, Straatman H, Verbeek ALM. Evaluation of treatment regimens to cure Helicobacter pylori infection—a meta-analysis. Aliment Pharmacol Ther 1999; 13: 85764.
  • 31
    European Study Group on Antibiotic Susceptibility of Helicobacter pylori. Results of a multicenter European survey in 1991 of metronidazole resistance in Helicobacter pylori. Eur J Clin Microbiol Infect Dis 1992; 11: 77781.
  • 32
    Mégraud F, Doermann HP. Clinical relevance of resistant strains of Helicobacter pylori: a review of current data. Gut 1998; 43(Suppl. 1): S61S65.
  • 33
    Adamek RJ, Suerbaum S, Pfaffenbach B, Opferkuch W. Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole, and amoxicillin—influence on treatment outcome. Am J Gastroenterol 1998; 93: 3869.
  • 34
    Moayyedi P, Sahay P, Tompkins DS, Axon ATR. Efficacy and optimum dose of omeprazole in a new 1-week triple therapy regimen to eradicate Helicobacter pylori. Eur J Gastroenterol Hepatol 1995; 7: 83540.
  • 35
    Moayyedi P, Ragunathan PL, Mapstone N, Axon ATR, Tomkins DS. Relevance of antibiotic sensitivities in predicting failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. J Gastroenterol 1998; 33: 1603.
  • 36
    Goh KL, Parasakti N, Chuah SY, Cheah PL, Lo YL, Chin SC. Comparison of two 1-week low-dose omeprazole triple therapies—Optimal treatment for Helicobacter pylori infection. Aliment Pharmacol Ther 1997; 11: 11158.
  • 37
    Lerang F, Moum B, Huang JB, et al. Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance? Am J Gastroenterol 1997; 92: 24853.
  • 38
    Schwartz H, Krause R, Siepman N, et al. Seven-day triple therapy with lansoprazole, clarithromycin, and metronidazole for the cure of Helicobacter pylori infection: a short report. Helicobacter 1996; 1: 2515.
  • 39
    Miyaki H, Azuma T, Ito S, et al. Susceptibility of Helicobacter pylori isolates to metronidazole, clarithromycin and amoxycillin in vitro and in clinical treatment in Japan. Aliment Pharmacol Ther 1997; 11: 11316.
  • 40
    Perng CL, Kim JG, El-Zimaity HM, Osato MS, Graham DY. One-week triple therapy with lansoprazole, clarithromycin, and metronidazole to cure Helicobacter pylori infection in peptic ulcer disease in Korea. Dig Dis Sci 1998; 43: 4647.
  • 41
    Chu KM, Choi HK, Tuen HH, Law SYK, Branicki FJ, Wong J. A prospective randomized trial comparing the use of omeprazole-based dual and triple therapy for eradication of Helicobacter pylori. Am J Gastroenterol 1998; 93: 143642.
    Direct Link:
  • 42
    Houben MHMG, Van de Beek D, Hensen EF, De Craen AJM, Rauws EAJ, Tytgat GNJ. A systematic review of Helicobacter pylori eradication therapy-the impact of antimicrobial resistance on eradication rates. Aliment Pharmacol Ther 1999; 13: 104755.
  • 43
    Buckley MJ, Xia HX, Hyde DM, Keane CT, O'Morain CA. Metronidazole resistance reduces efficacy of triple therapy and leads to secondary clarithromycin resistance. Dig Dis Sci 1997; 42: 21115.
  • 44
    Powell DU, Bell GD, Bowden AF, Trowell JE, Jones PH. An effective one-week Helicobacter pylori eradication therapy using omeprazole, clarithromycin and metronidazole. Br J Clin Res 1995; 6: 8590.
  • 45
    Harris AW, Pryce DI, Gabe SM, et al. Lansoprazole, clarithromycin and metronidazole for seven days in Helicobacter pylori infection. Aliment Pharmacol Ther 1996; 1: 10058.
  • 46
    Xia H, Keane CT, Beattle S, O'Morain CA. Standardisation of disk diffusion test and its clinical significance for susceptibility testing of metronidazole against H. pylori. Antimicrob Agents Chemother 1994; 38: 235761.
  • 47
    Realdi G, Dore MP, Piana A, et al. Pretreatment antibiotic resistance in Helicobacter pylori infection: Results of three randomized controlled studies. Helicobacter 1999; 4: 10612.
  • 48
    Bazzoli F, Zagari M, Pozzato P, et al. Evaluation of short-term low-dose triple therapy for the eradication of Helicobacter pylori by factorial design in a randomized, double-blind, controlled study. Aliment Pharmacol Ther 1998; 12: 43945.
  • 49
    Van Der Wouden EJ, Thijs JC, Van Zwet AA, Sluiter WJ, Kleibeuker JH. The influence of in vitro nitroimidazole resistance on the efficacy of nitroimidazole-containing anti-Helicobacter pylori regimens. A meta-analysis. Am J Gastroenterol 1999; 94: 17519.
  • 50
    Bazzoli F, De Berretti D, Luca L, et al. What can be learnt from the new data about antibiotic resistance? Are there any practical clinical consequences of Helicobacter pylori antibiotic resistance? Eur J Gastroenterol Hepatol 1999; 11(Suppl. 2): S39S42.
  • 51
    Bazzoli F, Zagari RM, Fossi S, et al. Short-term low-dose triple therapy for the eradication of Helicobacter pylori. Eur J Gastroenterol Hepatol 1994; 6: 7737.
  • 52
    Labenz J, Stolte M, Rühl GH, et al. One-week low-dose triple therapy for the eradication of Helicobacter pylori. Eur J Gastroenterol Hepatol 1995; 7: 911.
  • 53
    Jaup BH, Norrby A. Low dose, short-term triple therapy for cure of Helicobacter pylori infection and healing of peptic ulcers. Am J Gastroenterol 1995; 90: 9435.
  • 54
    Tzivras M, Archimandritis A, Balatsos V, et al. One-week therapy with omeprazole, clarithromycin, and metronidazole or ornidazole, followed by 3 weeks’ treatment with omeprazole, eradicates Helicobacter pylori equally and heals duodenal ulcer. Eur J Gastroenterol Hepatol 1997; 9: 11859.
  • 55
    Zullo A, Rinaldi V, Pugliano F, Diana F, Attili AF. Omeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori infection: a randomized prospective study. Am J Gastroenterol 1997; 92: 202931.
  • 56
    Yousfi MM, El-Zimaity HMT, Al-Assi MT, Cole RA, Genta RM, Graham DY. Metronidazole, omeprazole and clarithromycin; and effective combination therapy for Helicobacter pylori infection. Aliment Pharmacol Ther 1995; 9: 20912.
  • 57
    O'Connor HJ, Loane J, Bindel H, Bhutta AS, Cunnane K. One week triple therapy for Helicobacter pylori: does high-dose clarithromycin confer additional benefit? Helicobacter 1997; 2: 199204.
  • 58
    Cayla R, Zerbib F, Talbi P, Mégraud F, Lamouliatte H. Pre- and post-treatment clarithromycin resistance of Helicobacter pylori strains: a key factor of treatment failure. Gut 1995; 37(Suppl. 2): A152A152(Abstract).
  • 59
    Treiber G. The influence of drug dosage on Helicobacter pylori eradication: a cost-effectiveness analysis. Am J Gastroenterol 1996; 91: 24657.
  • 60
    Duggan AE, Tolley K, Hawkey CJ, Logan RF. Varying efficacy of Helicobacter pylori eradication regimens: cost effectiveness study using a decision analysis model. Br Med J 1998; 316: 164854.