Review article: agents affecting gall-bladder motility – role in treatment and prevention of gallstones


Correspondence to: Dr K.J. van Erpecum, Department of Gastroenterology, University Medical Center, PO Box 85500, 3508 GA Utrecht, the Netherlands.


Various agents may either enhance or impair post-prandial gall-bladder motility, and they are identified in this review. When studying the impact of medication on gall-bladder motility, the effects on interdigestive gall-bladder and intestinal motility should also be taken into account. Patients at high risk of gallstone disease, and patients who are treated chronically with gall-bladder motility inhibiting drugs, may benefit from improved gall-bladder motility using a prokinetic agent. However, there are no long-term studies to prove that such a strategy prevents gallstone formation.