Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects

Authors


Dr C. Beglinger, Division of Gastroenterology, University Hospital, CH-4031 Basel, Switzerland. E-mail: beglinger@tmr.ch

Abstract

Background:

Serotonin and its type-4 (5-hydroxytryptamine4) receptor play a major role in the physiology of the gastrointestinal tract. The effect of intravenous and/or oral tegaserod, a 5-hydroxytryptamine4 receptor partial agonist, on gastric emptying, small bowel transit and colonic transit has not been studied in detail in humans.

Aim:

To assess the pharmacodynamic effects of repeated oral and intravenous administration of tegaserod on gastric emptying and small intestine and colonic transit.

Methods:

A randomized, placebo-controlled, double-blind, three-way, crossover study of 6 mg oral and 0.6 mg intravenous tegaserod in 12 healthy male subjects was performed. Each treatment arm of the study involved 3 days of twice-daily administration and 1 day of daily administration of the study drugs.

Results:

In comparison with placebo, oral and intravenous tegaserod significantly increased the gastric emptying rate (< 0.01), accelerated colonic filling (< 0.01) and shortened colonic transit at 48 h (< 0.05). Tegaserod shortened the small intestine transit time by 30% after oral and by 37% after intravenous administration.

Conclusions:

In healthy subjects, tegaserod markedly accelerated gastric emptying and small intestinal transit, and induced a small but significant acceleration of colonic transit. Tegaserod can act as a promotile agent throughout the gastrointestinal tract.

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