• 1
    Smout AJPM. Endoscopy-negative acid reflux disease. Aliment Pharmacol Ther 1997; 11(Suppl. 2): 815.
  • 2
    Fass R, Fennerty B, Vakil N. Nonerosive reflux disease — current concepts and dilemmas. Am J Gastroenterol 2001; 96: 30314.
  • 3
    Quigley EMM, DiBaise JK. Non-erosive reflux disease: the real problem in gastro-oesophageal reflux disease. Dig Liver Dis 2001; 33: 5237.
  • 4
    Lind T, Havelund T, Carlsson R, et al. Heartburn without esophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol 1997; 32: 9749.
  • 5
    Richter JE, Peura D, Benjamin SB, et al. Efficacy of omeprazole for the treatment of symptomatic acid reflux disease without esophagitis. Arch Intern Med 2000; 160: 18106.
  • 6
    Bate CM, Keeling PWN, Axon ATR, et al. Reflux symptom relief with omeprazole in patients without unequivocal oesophagitis. Aliment Pharmacol Ther 1996; 10: 54755.
  • 7
    Cadiot G, Bruhat A, Rigaud D, et al. Multivariate analysis of pathophysiological factors in reflux oesophagitis. Gut 1997; 40: 16774.
  • 8
    Koek GH, Tack J, Sifrim D, et al. The role of acid and duodenal gastroesophageal reflux in symptomatic GERD. Am J Gastroenterol 2001; 96: 203340.
    Direct Link:
  • 9
    Sifrim D, Holloway R, Silny J, et al. Composition of the postprandial refluxate in patients with gastroesophageal reflux disease. Am J Gastroenterol 2001; 96: 64755.
    Direct Link:
  • 10
    Trudgill NJ, Riley SA. Transient lower esophageal sphincter relaxations are no more frequent in patients with gastroesophageal reflux disease than in asymptomatic volunteers. Am J Gastroenterol 2001; 96: 256974.
    Direct Link:
  • 11
    Fletcher J, Wirz A, Young J, et al. Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Gastroenterology 2001; 121: 77583.
  • 12
    Fimmel CJ, Etienne A, Cilluffo T, et al. Long-term ambulatory gastric pH monitoring: validation of a new method and effect of H2 antagonists. Gastroenterology 1985; 88: 184251.
  • 13
    Savarino V, Tracci D, Dulbecco P, et al. Negative effect of ranitidine on the results of urea breath test for the diagnosis of Helicobacter pylori. Am J Gastroenterol 2001; 96: 34852.
    Direct Link:
  • 14
    Dixon MF, Genta RM, Yardley JH, et al. Classification and grading of gastritis, the updated Sydney system. Am J Surg Pathol 1996; 20: 116181.
  • 15
    Mela GS, Savarino V, Vigneri S. Optimizing the information obtained from continuous 24-hour gastric pH monitoring. Am J Gastroenterol 1992; 87: 9616.
  • 16
    Savarino V, Mela GS, Zentilin P, et al. Gastric aspiration versus antimony and glass pH electrodes. A simultaneous comparative in vivo study. Scand J Gastroenterol 1989; 24: 4349.
  • 17
    Winer BJ, Brown DR, Michels KM. Statistical Principles in Experimental Design, 3rd edn. New York: McGraw-Hill, 1991: 11020.
  • 18
    Johnson LF, DeMeester TR. Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol 1974; 62: 32532.
  • 19
    Kahrilas PJ, Quigley EMM. Clinical esophageal pH recording: a technical review for practice guideline development. Gastroenterology 1996; 110: 198296.
  • 20
    Savarino V, Mela GS, Zentilin P, et al. Time pattern of gastric acidity in Barrett's esophagus. Dig Dis Sci 1996; 41: 137983.
  • 21
    Mulholland MW, Reid BJ, Levine DS, et al. Elevated gastric acid secretion in patients with Barrett's metaplastic epithelium. Dig Dis Sci 1989; 34: 132935.
  • 22
    Collen MJ, Johnson DA, Sheridan MJ. Basal acid output and gastric acid hypersecretion in gastroesophageal reflux disease. Correlation with ranitidine therapy. Dig Dis Sci 1994; 39: 4107.
  • 23
    Hirschowitz BI. A critical analysis, with appropriate controls, of gastric acid and pepsin secretion in clinical esophagitis. Gastroenterology 1991; 101: 114958.
  • 24
    Savarino V, Mela GS, Scalabrini P, et al. 24-hour study of intragastric acidity in duodenal ulcer patients and normal subjects using continuous intraluminal pH-metry. Dig Dis Sci 1988; 33: 107780.
  • 25
    Savarino V, Mela GS, Zentilin P, et al. Circadian acidity pattern in gastric ulcers at different sites. Am J Gastroenterol 1995; 90: 2548.
  • 26
    O'Connor HJ. Review article: Helicobacter pylori and gastro-oesophageal reflux disease. Clinical implications and management. Aliment Pharmacol Ther 1999; 13: 11727.
  • 27
    Vigneri S, Termini R, Savarino V, et al. Review article: is Helicobacter pylori status relevant in the management of GERD? Aliment Pharmacol Ther 2000; 14(Suppl. 3): 3142.
  • 28
    Wagner S, Freise J, Beholz S, et al. Campylobacter pylori and gastric acidity. Am J Gastroenterol 1989; 84: 2014.
  • 29
    Rademaker JW, Hunt RH. Helicobacter pylori and gastric acid secretion: the ulcer link? Scand J Gastroenterol 1991; 26(Suppl. 187): 717.
  • 30
    Montbriand JR, Appleman HD, Cotner EK, et al. Treatment of Campylobacter pylori does not alter gastric acid secretion. Am J Gastroenterol 1989; 84: 15136.
  • 31
    Tucci A, Corinaldesi R, Stanghellini V, et al. Helicobacter pylori infection and gastric function in patients with chronic idiopathic dyspepsia. Gastroenterology 1992; 103: 76874.
  • 32
    Schwizer W, Thumshirm M, Dent J, et al. Helicobacter pylori and symptomatic relapse of gastro-oesophageal reflux disease: a randomised controlled trial. Lancet 2001; 357: 173842.
  • 33
    Bowrey DJ, Clark GWB, Williams GT. Pattern of gastritis in patients with gastro-oesophageal reflux disease. Gut 1999; 45: 798803.
  • 34
    DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 1999; 94: 143442.
    Direct Link:
  • 35
    Watson RGP, Tham TCK, Johnston BT, et al. Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux: the ‘sensitive esophagus’. Gut 1997; 40: 58790.
  • 36
    Klauser AF, Schindlbeck NE, Muller-Lissner SA. Symptoms in gastro-oesophageal reflux disease. Lancet 1990; 335: 2058.
  • 37
    Orr WC, Allen ML, Robinson M. The pattern of nocturnal and diurnal esophageal acid exposure in the pathogenesis of erosive mucosal damage. Am J Gastroenterol 1994; 89: 50912.
  • 38
    Sifrim D, Silny J, Holloway RH, et al. Patterns of gas and liquid reflux during transient lower esophageal sphincter relaxation: a study using intraluminal electrical impedance. Gut 1999; 44: 4754.
  • 39
    Fass R, Naliboff B, Higa L, et al. Differential effect of long-term oesophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998; 115: 136373.
  • 40
    Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but no excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 1995; 37: 712.