Esomeprazole 20 mg and lansoprazole 15 mg in maintaining healed reflux oesophagitis: Metropole study results
Version of Record online: 11 MAR 2003
Alimentary Pharmacology & Therapeutics
Volume 17, Issue 3, pages 333–341, February 2003
How to Cite
Lauritsen, K., Devière, J., Bigard, M.-A., Bayerdörffer, E., Mózsik, G., Murray, F., Kristjánsdóttir, S., Savarino, V., Vetvik, K., De Freitas, D., Orive, V., Rodrigo, L., Fried, M., Morris, J., Schneider, H., Eklund, S. and Larkö, A. (2003), Esomeprazole 20 mg and lansoprazole 15 mg in maintaining healed reflux oesophagitis: Metropole study results. Alimentary Pharmacology & Therapeutics, 17: 333–341. doi: 10.1046/j.1365-2036.2003.01464.x
- Issue online: 11 MAR 2003
- Version of Record online: 11 MAR 2003
- Accepted for publication 21 November 2002
Aim : To compare the efficacy of esomeprazole, 20 mg once daily, vs. lansoprazole, 15 mg once daily, for the maintenance treatment of patients with healed reflux oesophagitis.
Methods : During the initial open healing phase, 1391 patients with endoscopically verified reflux oesophagitis and a history of heartburn, with or without acid regurgitation, received esomeprazole 40 mg for 4–8 weeks. Patients who were healed (identified by endoscopy at 4 or 8 weeks) and symptom free were then randomized to receive 6 months of treatment with esomeprazole, 20 mg once daily, or lansoprazole, 15 mg once daily.
Results : Esomeprazole, 20 mg once daily, maintained a significantly higher proportion of patients in remission than lansoprazole, 15 mg once daily, over 6 months [83% (95% CI, 80–86%) of esomeprazole recipients compared with 74% (95% CI, 70–78%) of lansoprazole recipients; P < 0.0001; life table estimates]. When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.
Conclusion : Esomeprazole, 20 mg once daily, is more effective than lansoprazole, 15 mg once daily, in maintaining remission in patients with healed reflux oesophagitis.