Effects of asimadoline, a κ-opioid agonist, on satiation and postprandial symptoms in health
Article first published online: 1 SEP 2003
Alimentary Pharmacology & Therapeutics
Volume 18, Issue 5, pages 507–514, September 2003
How to Cite
Delgado-Aros, S., Chial, H. J., Cremonini, F., Ferber, I., Mckinzie, S., Burton, D. D. and Camilleri, M. (2003), Effects of asimadoline, a κ-opioid agonist, on satiation and postprandial symptoms in health. Alimentary Pharmacology & Therapeutics, 18: 507–514. doi: 10.1046/j.1365-2036.2003.01670.x
- Issue published online: 1 SEP 2003
- Article first published online: 1 SEP 2003
- Accepted for publication 30 May 2003
Aim: To evaluate the effect of single administrations of asimadoline, a κ-opioid agonist, on satiation volume, postprandial symptoms and gastric volumes.
Methods: Healthy subjects received oral placebo, or 0.5 or 1.5 mg asimadoline in a randomized, double-blind fashion 1 h prior to testing. We assessed effects on the volume of Ensure to achieve full satiation and postprandial symptoms 30 min after meal, and on gastric volume (fasting and postprandial) measured by 99mTc-single photon emission tomography (SPECT) imaging.
Results: Thirteen healthy subjects were studied in each treatment arm. Compared to placebo, asimadoline 0.5 mg decreased postprandial fullness (P = 0.027) without affecting the volume ingested at full satiation (P = 0.6). Asimadoline 1.5 mg decreased satiation during meal, allowing increased satiation volumes (P = 0.008) and tended to decrease postprandial fullness (P = 0.067), despite higher volumes ingested. There was a significant treatment–gender interaction in the effect of asimadoline on gastric volumes (P < 0.05). Asimadoline 0.5 mg (not 1.5 mg) increased fasting (P = 0.047) and postprandial (P = 0.009) gastric volumes in females but decreased fasting volumes in males (P = 0.008). The effect of asimadoline on gastric volume did not explain the effect observed on satiation volume (P = 0.371) or postprandial fullness (P = 0.399).
Conclusion: A single oral administration of asimadoline decreases satiation and postprandial fullness in humans independently of its effects on gastric volume.