• 1
    Venateswaran PS, Millman I, Blumberg BS. Effects of an extract from Phyllanthus niruri on hepatitis B virus and woodchuck hepatitis viruses: in vitro and in vivo studies. Proc Natl Acad Sci USA, 1987; 0: 2748.
  • 2
    Chang CW, Lin MT, Lee SS, Liu KC, Hsu FL, Lin JY. Differential inhibition of reverse transcriptase and cellular DNA polymerase-alpha activities by lignans isolated from Chinese herbs, Phyllanthus myritifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix. Antiviral Res 1995; 27: 36774.
  • 3
    Lee CD, Ott M, Thyagarajan SP. Shafritz DA, Burk RD, Gupta S. Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication. Eur J Clin Inves, 1996; 26: 106976.
  • 4
    Ott M, Thyagarajan SP, Gupta S. Phyllanthus amarus suppresses hepatitis B virus by interrupting interactions between HBV enhancer I and cellular transcription factors. Eur J Clin Invest 1997; 27: 90815.
  • 5
    Kiemer AK, Hartung T, Huber C, Vollmar AM. Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kB pathway. J Hepatol 2003; 38: 28997.
  • 6
    Thyagarajan SP, Subramanian S, Thirunalasundar T, Vendateswaran PS, Blumberg BS. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. Lancet 1988; 332: 7646 .
  • 7
    Leelarasamee A, Trakulsomboon S, Maunwongtathi P, et al. Failure of Phyllanthus amarus to eradicate hepatitis B surface antigen from symptomless carriers. Lancet 1990; 335: 16001.
  • 8
    Wang M, Cheng H, Li Y, Meng L, Zhao G, Mai K. Herbs of the genus Phyllanthus in the treatment of chronic hepatitis B. observations with three preparation from different geographic sites. J Laboratory Clin Med 1995; 126: 3502.
  • 9
    Liu J, Lin H, McIntosh H. Genus Phyllanthus for chronic hepatitis B virus infection: a systemic review. J Viral Hepatol 2001; 8: 35866.
  • 10
    Chan HLY, Leung NWY, Lau TCM, Wong ML, Sung JJY. Comparison of three different sensitive assays for hepatitis B virus (HBV) DNA in monitoring response of anti-viral therapy. J Clin Microbiol 2000; 38: 32058.
  • 11
    Loeb KR, Jerome KR, Goddard J, Huang ML, Cent A, Corey L. High-throughput quantitative analysis of hepatitis B virus DNA in serum using the TaqMan fluorogenic detection system. Hepatology 2000; 32: 6269.
  • 12
    Chan HLY, Chui AKK, Lau WY, et al. Factors associated with viral breakthrough in lamivudine monoprophylaxis of hepatitis B virus recurrence after liver transplantation. J Med Virol 2002; 68: 1827.
  • 13
    Chan HLY, Wong ML, Leung NWY, et al. Pegylated interferon has additional antiviral effect on lamivudine in the treatment of chronic hepatitis B. Hepatology 2002; 36: 624A.
  • 14
    Lai CL, Rosmawati M, Lao J, et al. Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection. Gastroenterology 2002; 123: 18318.
  • 15
    Thyagarajan SP, Jayaram S, Gopalakrishnan B, Hari R, Jeyakumar P, Spipathi MS. Herbal medicines for liver diseases in India. J Gastroenterol Hepatol 2002; 17: S370S376.
  • 16
    Liaw YF, Chu CM, Huang MJ, Sheen IS, Yang CY, Lin DY. Determinants for hepatitis B e antigen clearance in chronic type B hepatitis. Liver 1984; 4: 3016.
  • 17
    Lok AS, Lai CL, Wu PC, Leung EK, Lam TS. Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection. Gastroenterology 1987; 92: 183943.