Esomeprazole resolves chronic heartburn in patients without erosive oesophagitis

Authors


Dr P. O. Katz, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141 USA.
E-mail: pkatz19512@aol.com

Summary

Background : Patients with chronic heartburn but with no endoscopic evidence of erosive oesophagitis require gastric acid suppression to relieve symptoms.

Aim : To assess the efficacy and safety of esomeprazole in patients with frequent heartburn for ≥ 6 months and no evidence of erosive oesophagitis on endoscopy.

Methods : Two randomized, double-blind, 4-week, multi-centre trials with identical methodology compared once-daily esomeprazole, 40 mg (n = 241) or 20 mg (n = 234), with placebo (n = 242) for the rigorous end-point of complete resolution of heartburn. Secondary end-points included the percentage of heartburn-free days and the time to first and sustained resolution of heartburn.

Results : Patients treated with either dose of esomeprazole were two to three times more likely to achieve complete resolution of heartburn than patients treated with placebo (P < 0.001). The percentage of heartburn-free days was significantly higher with esomeprazole 40 mg (63%, 66%) or 20 mg (63%, 68%) than with placebo (46%, 36%; P ≤ 0.001) in each of the two studies. Esomeprazole was associated with a significantly shorter mean time to first (6–7 days) and sustained (12–17 days) resolution of heartburn compared with placebo (first, 10–12 days; sustained, 21–22 days; P ≤ 0.008). The spectrum and frequency of adverse events with esomeprazole were similar to those with placebo.

Conclusions : Esomeprazole, at daily doses of 40 mg or 20 mg, is effective and safe for the treatment of chronic heartburn in patients without erosive oesophagitis.

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