A comparison of midazolam co-induction with propofol predosing for induction of anaesthesia


L. Anderson Department of Anaesthetics, Falkirk and District Royal Infirmary, Major's Loan, Falkirk FK1 5QE, UK


In a double-blind, placebo-controlled study of 90 ASA 1 and 2 patients scheduled for elective surgery we compared the effect of pre-administering midazolam 2 mg or propofol 30 mg on the dose of propofol subsequently required to induce anaesthesia. Using loss of response to verbal command and tolerance to placement of a facemask as end-points, the dose of propofol required to induce anaesthesia was significantly smaller in the patients given propofol (1.87 mgkg−1) or midazolam (1.71 mgkg−1) when compared to the control group (2.38 mgkg−1). Although the decrease in blood pressure following induction was significantly greater in the propofol group when compared to the control group, there was no difference between the two study groups and the decrease was felt not to be of clinical significance in this group of patients. As propofol is presented ‘… for use in a single patient only’ and the technique of predosing with propofol allowed induction of all patients with less than 200 mg (a single ampoule), we question on a cost basis whether midazolam co-induction is necessary to reduce propofol induction doses.