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No effect of short-term omeprazole intake on acenocoumarol pharmacokinetics and pharmacodynamics
Article first published online: 2 OCT 2003
DOI: 10.1046/j.1365-2125.1997.00600.x
1365-2125/asset/cover.gif?v=1&s=3e2bd7e8ead66ccf0afe5cc2432c3cd173fcfb7f "British Journal of Clinical Pharmacology")
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How to Cite
De Hoon, J. N. J. M., Thijssen, H. H. W., Beysens, A. J. M. M. and Van Bortel, L. M. A. B. (1997), No effect of short-term omeprazole intake on acenocoumarol pharmacokinetics and pharmacodynamics. British Journal of Clinical Pharmacology, 44: 399–401. doi: 10.1046/j.1365-2125.1997.00600.x
Publication History
- Issue published online: 2 OCT 2003
- Article first published online: 2 OCT 2003
- Abstract
- Cited By
Keywords:
- drug interaction;
- acenocoumarol;
- omeprazole;
- oral anticoagulants
Aims To investigate the effect of omeprazole on the pharmacokinetics of R- and S-acenocoumarol and on their combined anticoagulant activity.
Methods Eight healthy male subjects completed a double-blind, randomized, placebo-controlled, two-way cross-over study. Subjects were given either omeprazole 40 mg or placebo once daily for 3 days. On day 2 of each study period, a single 10 mg oral dose of racemic acenocoumarol was administered and venous blood samples were collected for pharmacokinetic and pharmacodynamic assessments. A wash-out period of 2 weeks separated the two study periods.
Results The pharmacokinetics of R- and S-acenocoumarol (AUC 3016±221 and 233±14 ng ml−1 h, respectively) did not change after omeprazole (AUC 2929±256 and 220±18 ng ml−1 h, respectively). Anticoagulant activity (INRmax 1.7±0.1) was unaffected by co-administration of omeprazole (INRmax 1.7±0.1).
Conclusions The short-term intake of omeprazole does not affect acenocoumarol pharmacokinetics or pharmacodynamics. These data differ from the results of previous studies on the effect of omeprazole on warfarin, suggesting a different in vivo interaction profile of omeprazole on acenocoumarol than on warfarin. Drug interaction studies with oral anticoagulants should not be restricted to the use of warfarin.