Absorption of sunscreens across human skin: an evaluation of commercial products for children and adults
Version of Record online: 24 DEC 2001
British Journal of Clinical Pharmacology
Volume 48, Issue 4, pages 635–637, October 1999
How to Cite
Jiang, Roberts, Collins and Benson (1999), Absorption of sunscreens across human skin: an evaluation of commercial products for children and adults. British Journal of Clinical Pharmacology, 48: 635–637. doi: 10.1046/j.1365-2125.1999.00056.x
- Issue online: 24 DEC 2001
- Version of Record online: 24 DEC 2001
- skin penetration;
- topical application
Aims Topical sunscreens are routinely applied to the skin by a large percentage of the population. This study assessed the extent of absorption of a number of common chemical sunscreen agents into and through human skin following application of commercially available products.
Methods Sunscreen products were applied to excised human epidermis in Franz diffusion cells with the amount penetrating into and across the epidermis assessed by h.p.l.c. for 8 h following application.
Results All sunscreen agents investigated penetrated into the skin (0.25 g m−2 or 14% of applied dose), but only benzophenone-3 passed through the skin in significant amounts (0.08 g m−2 or 10% of the applied dose). With one exception, suncreen agents in corresponding products marketed for adults and children had similar skin penetration profiles.
Conclusions Whilst limited absorption across the skin was observed for the majority of the sunscreens tested, benzophenone-3 demonstrated sufficiently high penetration to warrant further investigation of its continued application.