Epidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine
Version of Record online: 5 APR 2002
British Journal of Clinical Pharmacology
Volume 49, Issue 2, pages 158–167, February 2000
How to Cite
Fattinger, K., Roos, M., Vergères, P., Holenstein, C., Kind, B., Masche, U., Stocker, D. N., Braunschweig, S., Kullak-Ublick, G. A., Galeazzi, R. L., Follath, F., Gasser, T. and Meier, P. J. (2000), Epidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine. British Journal of Clinical Pharmacology, 49: 158–167. doi: 10.1046/j.1365-2125.2000.00132.x
- Issue online: 5 APR 2002
- Version of Record online: 5 APR 2002
- Cited By
- adverse drug reactions;
- event monitoring;
- hospital pharmacoepidemiology;
- medication usage
Aims To explore drug exposure, frequency of adverse drug reactions (ADRs), types of ADRs, predisposing risk factors and ADR-related excess hospital stay in medical inpatients.
Methods Structured data regarding patient characteristics, ‘events’ (symptoms, laboratory results), diagnoses (ICD10) and drug therapy were collected using a computer-supported data entry system and an interface for data retrieval from electronic patient records. ADR data were collected by ‘event monitoring’ to minimize possible bias by the drug monitor. The causality of each event was assessed in relation to disease(s) and drug therapy.
Results The analysis included 4331 (100%) hospitalizations. The median observation period was 8 days. The median number of different drugs administered per patient and day was 6 and varied between 4 (Q1 ) and 9 (Q3 ) different drugs in 50% of all hospital days. In 41% of all hospitalizations at least one disease-unrelated event could be possibly attributed to drug therapy. Clinically relevant ADRs occurred in 11% of all hospitalizations. In 3.3% of all hospitalizations ADRs were the cause of hospital admission. The incidence of possibly ADR-related deaths was 1.4. Factors predisposing for clinically relevant ADRs were female gender and polypharmacy. ADR-related excess hospital stay accounted for 8.6% of hospital days.
Conclusions These data demonstrate the feasibility of the developed ‘event monitoring’ system for quantitative analysis of ADRs in medical inpatients. With increasing numbers of recorded patients the pharmacoepidemiological database provides a valuable tool to study specific questions regarding drug efficacy and safety in hospitalized patients.