Dose–response relationship and reproducibility of urinary salbutamol excretion during the first 30 min after an inhalation
Version of Record online: 27 JUN 2003
British Journal of Clinical Pharmacology
Volume 56, Issue 2, pages 225–227, August 2003
How to Cite
Tomlinson, H. S., Corlett, S. A. and Chrystyn, H. (2003), Dose–response relationship and reproducibility of urinary salbutamol excretion during the first 30 min after an inhalation. British Journal of Clinical Pharmacology, 56: 225–227. doi: 10.1046/j.1365-2125.2003.01864.x
- Issue online: 3 JUL 2003
- Version of Record online: 27 JUN 2003
- Received 29 October 2002, accepted 27 January 2003.
- urinary salbutamol
Aims To determine the reproducibility and dose–response relationship for urinary salbutamol excretion post inhalation.
Methods Fifteen volunteers inhaled either one, two, three, four or five doses of 100 µg salbutamol on separate days and then seven of these also repeated each of the one, three and five doses on five occasions. After each study dose urine was collected 30 min post inhalation.
Results The mean (SD) 30 min urinary salbutamol after one, two, three, four and five doses was 2.61 (1.0.), 5.47 (1.59), 8.68 (2.73), 12.34 (3.96) and 15.99 (4.50) µg, respectively. Statistical analysis revealed a linear relationship (P < 0.001). Mean (SD) coefficient of variation after one, three and five doses was 10.5 (3.6), 10.1 (2.7) and 9.4 (2.3)%.
Conclusions The 30 min salbutamol urinary excretion post inhalation pharmacokinetic method, to compare inhaled products, is linear with inhaled dose and reproducible.