• 1
    Cunningham G, Dodd TRP, Grant DJ, Murdo MET, Richards RME. Drug-related problems in elderly patients admitted to Tayside hospitals, methods for prevention and subsequent reassessment. Age Ageing 1997; 26: 375382.
  • 2
    Mannesse CK, Derkx FH, De Ridder MA, Man in ‘t Veld AJ, Van Der Cammen TJ. Adverse drug reactions in elderly patients as contributing factor for hospital admission: cross sectional study. Br Med J 1997; 315: 10571058.
  • 3
    Mannesse CK, Derkx FH, De Ridder MA, Man in ‘t Veld AJ, Van Der Cammen TJ. Contribution of adverse drug reactions to hospital admission of older patients. Age Ageing 2000; 29: 3539.
  • 4
    Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 1998; 279: 12001205.
  • 5
    Wiffen P, Gill M, Edwards J, Moore A. Adverse drug reactions in hospital patients. Bandolier Extra 2002; 115
  • 6
    Anon. A spoonful of sugar; medicines management in NHS hospitals. London: Audit Commission, 2001.
  • 7
    Gurwitz JH, Avorn J. The ambiguous relation between aging and adverse drug reactions. Ann Intern Med 1991; 114: 956966.
  • 8
    Cooper JW. Probable adverse drug reactions in a rural geriatric nursing home population: a four-year study. J Am Geriatric Soc 1996; 44: 194197.
  • 9
    Williamson J, Chopin JM. Adverse reaction to prescribed drugs in the elderly: a multicentre investigation. Age Ageing 1980; 9: 7380.
  • 10
    Davidsen F, Haghfelt T, Gram LF, Brosen K. Adverse drug reactions and drug non-compliance as primary causes of admission to a cardiology department. Eur J Clin Pharmacol 1988; 34: 8386.
  • 11
    Carbonin P, Pahor M, Bernabei R, Sgadari A. Is age an independent risk factor of adverse drug reactions in hospitalized medical patients? J Am Geriatr Soc 1991; 39: 10931099.
  • 12
    Lassila HC, Stoehr GP, Ganguli M et al. Use of prescription medications in an elderly rural population: the MoVIES Project. Ann Pharmacother 1996; 30: 589595.
  • 13
    Straand J, Rokstad KS. Elderly patients in general practice: diagnoses, drugs and inappropriate prescriptions. A report from the More & Romsdal Prescription Study. Fam Pract 1999; 16: 380388.
  • 14
    Gholami K, Shalviri G. Factors associated with preventability, predictability, and severity of adverse drug reactions. Ann Pharmacother 1999; 33: 236240.
  • 15
    Bordet R, Gautier S, Le Louet H, Dupuis B, Caron J. Analysis of the direct cost of adverse drug reactions in hospitalised patients. Eur J Clin Pharmacol 2001; 6: 935941.
  • 16
    Dormann H, Krebs S, Muth-Selbach U et al. Adverse drug reactions in patients with gastroenterological diseases: does age increase the risk? Aliment Pharmacol Ther 2001; 15: 171180.
  • 17
    Rawlins MD, Thompson JP. Pathogenesis of adverse drug reactions. In Textbook of adverse drug reactions, ed DaviesDM. Oxford: Oxford University Press, 1977; 44.
  • 18
    Moore N, Lecointre D, Noblet C, Mabille M. Frequency and cost of serious adverse drug reactions in a department of general medicine. Br J Clin Pharmacol 1998; 45: 301308.
  • 19
    Lagnaouie R, Moore N, Fach J, Longy-Boursier M, Begaud B. Adverse drug reactions in a department of systemic diseases-oriented internal medicine: prevalence, incidence, direct costs and avoidability. Eur J Clin Pharmacol 2000; 56: 181186.
  • 20
    Green CF, Mottram DR, Rowe PH, Pirmohamed M. Adverse drug reactions as a cause of admission to an acute medical assessment unit: a pilot study. J Clin Pharm Ther 2000; 25: 355361.
  • 21
    McDonnell PJ, Jacobs MR. Hospital admissions resulting from preventable adverse drug reactions. Ann Pharmacother 2002; 36: 13311336.
  • 22
    Beijer HJ, De Blaey CJ. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci 2002; 24: 4654.
  • 23
    Suh DC, Woodall BS, Shin SK, Hermes-De Santis ER. Clinical and economic impact of adverse drug reactions in hospitalized patients. Ann Pharmacother 2000; 34: 13731379.
  • 24
    Bowman L, Carlstedt BC, Hancock EF, Black CD. Adverse drug reaction (ADR) occurrence and evaluation in elderly inpatients. Pharmacoepidemiol Drug Saf 1996; 5: 918.
  • 25
    Olsson R, Wiholm BE, Sand C, Zettergren L, Hultcrantz R, Myrhed M. Liver damage from flucloxacillin, cloxacillin, and dicloxacillin. J Hepatol 1992; 15: 151154.
  • 26
    Devereaux BM, Crawford DH, Purcell P, Powell LW, Roeser HP. Flucloxacillin associated cholestatic hepatitis. An Australian and Swedish epidemic? Eur J Clin Pharmacol 1995; 49: 8185.
  • 27
    Larrey D, Vial T, Micaleff A et al. Hepatitis associated with amoxycillin–clavulanic acid combination: report of 15 cases. Gut 1992; 33: 368371.
  • 28
    O'Mahony MS, Woodhouse KW. Age, environmental factors and drug metabolism. Pharmacol Ther 1994; 61: 279287.
  • 29
    Routledge PA. Therapeutics and toxicology. In Textbook of medicine, 4th edn, eds SouhamiRL, MoxhamJ. Edinburgh: Churchill Livingstone, 2002.
  • 30
    Lackner TE. Strategies for optimizing antiepileptic drug therapy in elderly people. Pharmacotherapy 2002; 22: 329364.
  • 31
    Nobili A, Tettamanti M, Frattura L et al. Drug use by the elderly in Italy. Ann Pharmacother 1997; 31: 416422.
  • 32
    Onder G, Pedone C, Landi F et al. Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA). J Am Geriatr Soc 2002; 50: 19621968.
  • 33
    Stewart RB, Cooper JW. Polypharmacy in the aged. Practical solutions. Drugs Aging 1994; 4: 449461.
  • 34
    Hudson RP. Polypharmacy in twentieth century America. Clin Pharmacol Ther 1968; 9: 210.
  • 35
    Hogerzeil HV. Promoting rational prescribing: an international perspective. Br J Clin Pharmacol 1995; 39: 16.
  • 36
    Willmore LJ. Management of epilepsy in the elderly. Epilepsia 1996; 37 (Suppl 6): S23S33.
  • 37
    Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991; 114: 257263.
  • 38
    Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med 1991; 114: 735740.
  • 39
    Shorr RI, Ray WA, Daugherty JR, Griffin MR. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993; 153: 16651670.
  • 40
    Halsey JP, Cardoe N. Benoxaprofen: side-effect profile in 300 patients. Br Med J 1982; 284: 13651368.
  • 41
    Bedell SE, Jabbour S, Goldberg R et al. Discrepancies in the use of medications: their extent and predictors in an outpatient practice. Arch Intern Med 2000; 160: 21292134.
  • 42
    Atkin PA, Veitch PC, Veitch EM, Ogle SJ. The epidemiology of serious adverse drug reactions among the elderly. Drugs Aging 1999; 14: 141152.
  • 43
    Seymour RM, Routledge PA. Important drug–drug interactions in the elderly. Drugs Aging 1998; 12: 485494.
  • 44
    Routledge PA, Hutchings AD. Therapeutic Drug Monitoring (TDM). In The immunoassay handbook, 2nd edn. ed WildD. London: Nature Publishing Group, 2001.
  • 45
    Hamilton RA, Briceland LL, Andritz MH. Frequency of hospitalization after exposure to known drug–drug interactions in a Medicaid population. Pharmacotherapy 1998; 18: 11121120.
  • 46
    Tamblyn RM, McLeod PJ, Abrahamowicz M et al. Do too many cooks spoil the broth? Multiple physician involvement in medical management of elderly patients and potentially inappropriate drug combinations. CMAJ 1996; 154: 11741184.
  • 47
    Weideman RA, Bernstein IH, McKinney WP. Pharmacist recognition of potential drug interactions. Am J Health Syst Pharm 1999; 56: 15241529.
  • 48
    Shorr RI, Bauwens SF. Effects of patient age and physician training on choice and dose of benzodiazepine hypnotic drugs. Arch Intern Med 1990; 150: 293295.
  • 49
    Levy AR, Tamblyn RM, Mcleod PJ, Fitchett D, Abrahamowicz M. The effect of physicians’ training on prescribing beta-blockers for secondary prevention of myocardial infarction in the elderly. Ann Epidemiol 2002; 12: 8689.
  • 50
    Anonymous. Reducing and preventing adverse drug events to decrease hospital costs. Rockville, MD: Agency for Healthcare Research and Quality, 2000.
  • 51
    Hunt DL, Haynes RB, Hanna SE, Smith K. Effects of computer-based clinical decision support systems on physician performance and patient outcomes. A systematic review. JAMA 1998; 280: 13391346.
  • 52
    Raschetti R, Morgutti M, Menniti Ippolito F et al. Suspected adverse drug events requiring emergency department visits or hospital admissions. Eur J Clin Pharmacol 1999; 54: 959963.
  • 53
    Martin U, George CF. Drugs and the elderly. In Pharmacovigilance, eds MannR, AndrewsE. Chichester: Wiley, 2002.